Roman Sankowski

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions | Science Translational Medicine

www.science.org/doi/10.1126/...

Automated classification of cellular expression in multiplexed imaging data with Nimbus - Nature Methods Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Nimbus predicts the likelihood of marker positivity from multiplexed image data in single cells.

www.nature.com/articles/s41...

Preprint: The Autoantibodyome Neuroimmune Signature of Neurodegeneration
papers.ssrn.com/sol3/papers....

Cover of The Lancet's Oct 4, 2025 issue. Cover quote reads: "Most medical and surgical societies worldwide have remained silent or issued vague statements about Gaza's healthocide [...] Staying silent while pretending to be neutral is, in effect, a form of complicity."

On this week’s cover of The Lancet, a new letter: “Gaza’s healthocide: medical societies must not stay silent”.

Read the letter and more in our latest issue: tinyurl.com/5n85x448

Review @sciimmunology.bsky.social @platten-lab.bsky.social
@dkfz.bsky.social
The immunology of brain tumors
www.science.org/doi/10.1126/...

The immunology of brain tumors The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

Great update on #immunity of #brain #tumors by the Platten lab

The immunology of brain tumors | Science Immunology

www.science.org/doi/10.1126/...

Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production The ketogenic diet (KD) is a potential therapeutic strategy for glioma; however, the underlying mechanisms remain unclear. Herein, we first identify t…

Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production

www.sciencedirect.com/science/arti...

@d-kirschenbaum.bsky.social Presenting his data on immune cell dynamics in glioblastoma at the #DGNN annual meeting

Single-cell genomics: from bench to bioinformatics

Applications are now open for our single-cell genomics course.

This course covers the complete end-to-end workflow of single-cell sequencing, from experimental design to data analysis.

📅 18 – 21 November
Learn more and apply 👇
www.crick.ac.uk/whats-on/sin...

Nixon Lab is hoping to recruit a postdoctoral fellow interested in alcohol-microglia and/or alcohol-neural stem cell interactions in recovery from alcohol-induced brain and behavioral damage/dysfunction. Open fellowships on our NIAAA-funded T32! Please spread the word!

PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids Accumulating evidence implicates non-neuronal cells in ALS pathogenesis. Using patient-derived cerebral organoids, Ljubikj et al. reveal reduced microglial

In our new study in BRAIN, we use a brain organoid model in which microglia innately develop to further dissect the mechanisms that cause changes in microglia in C9ORF72-ALS and show that PU.1 can help to reverse these pathogenic phenotypes. #GoALS
academic.oup.com/brain/advanc...

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia - Nature A PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

Nature research paper: PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

go.nature.com/46cuA0E

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Great Work! Congrats to Katrin and Team!!

Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface Petry et al. demonstrate a defined migration route of microglia progenitors from the surrounding mesenchyme into the embryonic CNS. This process relies on integrin activation and interactions with the...

Our newest study is out🥳! Big shout out to Alex and Philippe for their amazing work here 🫶🏻 and thx to all collaborators who helped us during this journey! And let me tell you… this is just one tiny puzzle piece of understanding microglia/macrophage tissue homing 😎 www.cell.com/developmenta...

Top left: Immunofluorescence images of anti-GFP (green) and anti-ATRX (red) counterstained with DAPI (blue) illustrating absence of ATRX in Sun1GFP+ microglia nuclei in 2-month-old ATRX miKO mice. Scale bar, 50 µm. Bottom left: Representative images of microglia tracings; Sholl analysis reveals excessive branching in ATRX miKO compared to control microglia. Right: Immunofluorescence staining of CD68 (green) and Ai14+ (red) cortical and hippocampal CA1 microglia. Scale bar, 50 µm.

What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @plosbiology.org 🧪 plos.io/46cBaE4

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior Chromatin-mediated processes are critical for neurodevelopment, but their role in microglia is less understood. This study shows that loss of the ATRX chromatin remodeler in microglia disrupts chromat...

#retroviral activation leads to microglia dysfunction and #cofnitive deficits in a non-cell autonomous way

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior | PLOS Biology

journals.plos.org/plosbiology/...

In situ Proteomics Unveils Specialized Domains for Extrasynaptic Signaling on Neuronal Cilia Neuronal cilia have emerged as crucial signaling hubs, yet their molecular composition and integration with synaptic communication remain poorly understood. Using a newly developed Arl13b-TurboID mous...

Whoa - neuronal ciliary proteome! Tons to dig into here - different from kidney cilia proteome (perhaps unsurprising) and enriched for many postsynaptic proteins, strengthening previous suggestions of cilia as postsynaptic signaling structures.
@nachury.bsky.social
www.biorxiv.org/content/10.1...

📢 Join us for the 2nd Microglia & Neuroinflammation Workshop in Bordeaux, Nov 3–7, 2025!
Pre-registration deadline extended to Sept 3—don’t miss out!
#Neuroscience #Microglia #Workshop2025

How do we evaluate your ERC proposal? In this video, Lucía Rubio Fernández walks you through the entire ERC evaluation process — from panel selection to interviews. Learn who reviews your proposal, how decisions are made, and how to best…

Today Lucía takes you by the hand and walks you through the entire ERC #evaluation process — from panel selection to interview.

Learn who reviews your #proposal, how decisions are made, & how to best increase your chance of success. 👇

#research #funding #grant #AcademicSky

Multimodal analysis of pediatric pilocytic astrocytomas reveals tumor location-associated cellular and transcriptional heterogeneity | Neuro-Oncology | Oxford Academic #brain #tumor

academic.oup.com/neuro-oncolo...

Improve the stewardship of federal research funds. #Science

"It is up to the research community to provide constructive solutions that improve accountability for federal money..."

www.science.org/doi/10.1126/...

Looking for a postdoc that combines wet and dry lab experience?

The EMBL-EBI-Sanger postdoctoral fellowships might be the thing for you!

Choose one of our pre-defined topics or propose your own.

www.ebi.ac.uk/research/pos...

@sangerinstitute.bsky.social

#postdoc #sciencecareers
🧬🖥️🔬

We are looking for a Technical Assistant (BTA, CTA, MTA) for our Research Department Totipotency. Feel free to apply if this position speaks to you.

❕ Apply until: October 15
❕ www.mpg.de/25289190/tec...

#hiring #jobalert #biochemistry #laboratory

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential @science.org
www.science.org/doi/10.1126/...

Key points from the Review Article "Educational Strategies for Clinical Supervision of Artificial Intelligence Use"

The authors of a new Review Article, the latest in the Medical Education series, propose a framework that leverages educational strategies to teach and assess critical thinking during clinical supervision of trainees wherever AI is being used. Read the full review: nej.md/47okmwr

Interferons in health and disease The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

Interferons in health and disease: Cell

www.cell.com/cell/fulltex...

Opinion | The Playbook Used to ‘Prove’ Vaccines Cause Autism (Gift Article) Data can easily be manipulated to show a causation that doesn’t exist.

A must-read, must-share piece - clearly deconstructing the shoddy science of the Geiers (who are inexplicably in charge of studies at HHS).

Consider this an early warning for what lies ahead. 🛟🩺🧪

www.nytimes.com/interactive/...

𝗖𝗼𝗴𝗻𝗶𝘁𝗶𝗼𝗻 𝗶𝘀 𝗲𝗺𝗲𝗿𝗴𝗲𝗻𝘁 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻
by Earl K Miller, Scott L Brincat, Jefferson E Roy
This promises to be a must read
One day we should create an online journal club to just read these kinds of papers!
#neuroskyence
doi.org/10.1016/j.co...