Roman Sankowski

If you think a golden ballroom is more important than childhood cancer research… I have nothing left to say to you. Please unfollow me.

#pediatriccancer #cancermom

It has taken medical science 200 years to advance humans to the point where people are so healthy and living so long that they can deny that science and medicine is what got us here.

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Two very cool back-to-back papers in @cp-cell.bsky.social on roles of meningeal dural mast cells in stroke and CSF dynamics 🤩😍👇🏻

cell.com/cell/fulltext/S0092-8674(25)00748-2

cell.com/cell/fulltext/S0092-8674(25)00747-0

Akteure, Verantwortlichkeiten und Rollen - Wissenschaftliche Integrität Die Rollen und die Verantwortlichkeiten der an einem Forschungsvorhaben beteiligten Wissenschaftler*innen sowie des wissenschaftsakzessorischen Personals müssen zu jedem Zeitpunkt eines Forschungsvorh...

#WissenschaftlicheIntegrität: Die Rollen und Verantwortlichkeiten der Beteiligten an einem #Forschungsvorhaben müssen klar festgelegt – aber im Verlauf ggf. auch angepasst werden. Was dabei zu beachten ist, erklärt Leitlinie 8 des Kodex zur #GWP:
wissenschaftliche-integritaet.de/kodex/akteur...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

Characterizing plaque-associated #microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues

www.nature.com/articles/s41...

Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...

👉 Attention young researchers‼️
Apply before Oct 31 for #BRIESEPreis for outstanding #PhD theses in #marineresearch, endowed with 5000 EUR 🚢

Previous awardees from our institute are Hagen Buck-Wiese, @kathikitzinger.bsky.social & @soerenahmerkamp.bsky.social

www.io-warnemuende.de/briese-award...

Top left: Schematic Representation: (Top Left) Mice were perfused and harvested at two-hour intervals over a 24-h period. The harvested mice were then sectioned coronally. (Bottom Left) Coronal brain sections at different brain levels. (Top Middle) The ciliary base was defined as the origin of the coordinate system, and the tip of the cilia was labeled. Cilia length was measured from the base to the tips, and the circular angle was determined. (Bottom Middle) The brain section of the mice was divided into left and right hemispheres. For cilia found in the right hemisphere, a counter-clockwise coordinate system was used to determine the circular angle (Right). For cilia found in the left hemisphere, a clockwise coordinate system was used (Left). (Top Right) An example of the angle measurement from cilia found in the right hemisphere. Bottom left: Representative images of immunofluorescence staining showing cilia labeled with the ADCY3 antibody (red) and the basal body (cilia base) labeled with the centrin 1 antibody (green). Right: Brain Regions analyzed for cilia length and angle.

Spatiotemporal analysis of >10 million #PrimaryCilia in 22 mouse #brain regions shows that #cilia have region-specific length & orientation patterns. #Circadian rhythms of cilia length suggest a role for cilia in the brain’s response to environmental changes @plosbiology.org 🧪 plos.io/4lWnfbQ

Congrats Yahaya!

Yes. The time is now. Vaccines to treat and prevent cancer.
www.jci.org/articles/vie...

Senior Editor Dr. Madhura Mukhopadhyay will be at the ISSCR conference at Hong Kong this week. Please get in touch with her directly by email if you would like catch up at #ISSCR2025!

The keynote lecture is about to start at the #NCII2025 meeting in Tübingen. Generative #AI Kicks it off with nice artwork

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting | @natneuro.nature.com

www.nature.com/articles/s41...

I am super happy to join this year's nightofscience.de. I'll represent the @cpi-exstra.bsky.social speaking on "Small vessels, big impact: How your heart's microcirculation affects ageing and disease". I am looking forward to meeting y'all!
@instcardregffm.bsky.social
@goetheuni.bsky.social

a man in a suit and tie is holding a brown jacket ALT: a man in a suit and tie is holding a brown jacket

Best research in the world? Most Nobel laureates? Most patents?

Europe is a top destination for researchers and innovators. And we’re aiming higher than ever.

Choose Science, Choose Europe. 🇪🇺

Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article) The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.

Masterful #dataviz on the current State of #Science #Funding in the US

Trump Has Cut Science Funding to Its Lowest Level in Decades - The New York Times

www.nytimes.com/interactive/...

Clinical Safety and Preliminary Efficacy of Regulatory T Cells for ALS Peripheral and neuroinflammation have been previously associated with progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease involving progressive loss of motor neurons. We...

Incredible approach to use allogenonic nonhuman regulatory T cells for #brain disorders. At least it’s safe but I’m curious to see if it works in many patients

Clinical Safety and Preliminary Efficacy of Regulatory T Cells for ALS | NEJM Evidence

evidence.nejm.org/doi/full/10....

A dynamic and multimodal framework to define microglial states - Nature Neuroscience Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a robust terminology with biol...

A Perspective on a dynamic and multimodal framework to define microglial states from @rsankowski.bsky.social and Marco Prinz

www.nature.com/articles/s41...

A dynamic and multimodal framework to define microglial states Nature Neuroscience - Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a...

Marco Prinz and I are discussing possible ways to classify microglia with regard to their true complexity. I see this as contribution to the debate with suggestions and examples from other cell types. Here is the #openaccess link: rdcu.be/emNVE @uni-freiburg.de

#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com

Combining spatial transcriptomics with tissue morphology - Nature Communications Spatial transcriptomics (ST) has transformed our knowledge of tissue biology through the examination of gene expression in cells within their tissue context. This review aims to categorise methods tha...

A few recent publications on Spatial Multi-Omics
www.nature.com/articles/s41...

New CAJAL course incoming!
Applications are now open #CancerNeuroscience (22 Sep – 10 Oct 2025) at the Bordeaux School of Neuroscience!
🔗More info: cajal-training.org/on-site/canc...
@varunvenkatesh.bsky.social, #AntonioPagano

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

Meticulously executed study o leptomeningeal metastasis-induced immunological changes at the brain border regions. Kudos to @meningojan.bsky.social and team! I learned a lot:

Interferon-γ orchestrates leptomeningeal anti-tumour response | @nature.com

www.nature.com/articles/s41...

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics Through integrative analyses of single-cell spatial multi-omics datasets, Liu et al. identify four distinct spatial subtypes of cancer-associated fibroblasts, conserved across cancer types and indepen...

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics | @cp-cancercell.bsky.social

www.cell.com/cancer-cell/...

IL-1β+ macrophages and the control of pathogenic inflammation in cancer While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated mac...

Fantastic review by Renato Ostuni and team on the conundrum how an inflammatory response can be immunosuppressive in #cancer

IL-1β+ macrophages and the control of pathogenic inflammation in cancer | @cp-trendscancer.bsky.social

www.cell.com/trends/immun...

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting oligodendroglial ho...

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

www.cell.com/cell/fulltex...

Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine This study examines the immunogenicity and safety of an investigational mRNA-based vaccine against seasonal influenza and SARS-CoV-2 in adults 50 years and older.

You can safely and effectively vaccinate against #COVID19 and seasonal #influenza at the same time, study shows

jamanetwork.com/journals/jam...

Tumor-draining lymph nodes – friend or foe during immune checkpoint therapy? The pivotal role of tumor-draining lymph nodes (TDLNs) in supporting antitumor immunity and serving as sites for cancer metastasis presents a clinical…

Tumor-draining lymph nodes – friend or foe during immune checkpoint therapy? | @cp-trendscancer.bsky.social

www.sciencedirect.com/science/arti...