Alvin Wei Tian Ng

The Somatic Mosaicism across Human Tissues Network - Nature The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...

02.07.2025 16:21 — 👍 113    🔁 33    💬 1    📌 1

If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.

30.06.2025 08:19 — 👍 81    🔁 14    💬 5    📌 4

Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat!

#CancerGrandChallenges #CGCecDNA

11.06.2025 08:44 — 👍 3    🔁 0    💬 0    📌 0

Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.

07.05.2025 19:28 — 👍 2    🔁 0    💬 0    📌 0

Interesting work from Khi Pin Chua, PhD on precise characterization of complex repeat regions in cancer genomes at #AACR25. Catch him at poster 2 in section 46 (#6288) until 5 PM! #PacBio

29.04.2025 19:29 — 👍 4    🔁 3    💬 0    📌 0

Eugenics is on the rise again: human geneticists must take a stand Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.

“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪

26.04.2025 22:37 — 👍 130    🔁 82    💬 8    📌 3

We should catch up! Was looking around to see if you were here!

26.04.2025 19:04 — 👍 1    🔁 0    💬 0    📌 0

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

26.04.2025 16:16 — 👍 5    🔁 0    💬 0    📌 0

Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!

26.04.2025 16:15 — 👍 0    🔁 0    💬 1    📌 0

Yes! - we are hiring @yale.edu - links below...

26.04.2025 00:26 — 👍 3    🔁 2    💬 1    📌 0

Highlights of day 1 of #MITS : @steverozen.bsky.social on Aristolochic Acids their effects on carcinogeneis
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig

24.04.2025 13:17 — 👍 1    🔁 0    💬 0    📌 0

The future of tumor organoids in precision therapy Tumoroids are cultures of patient-derived tumor cells, which are grown in 3D in the presence of an extracellular matrix extract and specific growth factors. Tumoroids can be generated from adult as we...

A wonderful reminder that my time spent comparing all the ecDNAs in organoids from the @RFitzgerald_lab added new insight to how we can use tumour organoids as a model to study ecDNA.
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...

09.04.2025 14:43 — 👍 3    🔁 1    💬 0    📌 0

And so it begins. I have been working in genomics / sequencing for more than 30 years but today is a particularly exciting day as I begin training on using the @nanopore MK1D sequencer which we will be using soon for student projects (and other things) at @ucdavis.bsky.social

19.03.2025 14:47 — 👍 97    🔁 8    💬 1    📌 1

The first Singapore Long-Reads Symposium was a success! A massive thanks to the speakers: Keynote Heng Li, Ken Sung @jonathangoeke.bsky.social , @msikic.bsky.social & industrial partners @nanoporetech.com , @pacbio.bsky.social , @awscloud.bsky.social MGI_Technology Next Level Genomics & NovogeneAIT

17.03.2025 02:32 — 👍 8    🔁 2    💬 0    📌 0

#lkcmedicine #lkcmedicine #acsi | Alvin Ng | 27 comments I'm happy to announce that I have been awarded the NMRC Open Fund - Young Individual Research Grant (OF-YIRG) for the project: Unveiling Risk Factors of Early-Onset Colorectal Cancers through…

I'm happy to announce that my project to use @nanoporetech.com sequencing to study Early Onset Colorectal Cancer has been funded!

25.02.2025 06:09 — 👍 7    🔁 1    💬 0    📌 0

Getting ahead of cancer: our 2024 research highlights - Cancer Research UK - Cancer News To end the year, we want to highlight some of our biggest stories of 2024, including big advances in prevention, diagnosis, and treatment.

Our 2024 Wrapped! 🧪

- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects

Read more about our progress this year 👇 cruk.ink/4iLz3ws

19.12.2024 10:01 — 👍 30    🔁 12    💬 3    📌 2

SPECIAL ISSUE! This month Genome Research publishes a diverse collection of research and review articles in a special issue highlighting advances in long-read sequencing applications in biology and medicine. Full issue links here: tinyurl.com/Genome-Res-3....

20.11.2024 15:10 — 👍 75    🔁 41    💬 0    📌 5