Don Sleeter

Yes, but be careful about self-definition and self-limitation and “core values” judgements. They are dark side emotions. You will be forced into uncomfortable situations and “not ideal” work. Stay flexible. You know who you are. You know what you believe. What you need is power.

This looks just like electrophoresis. I bet same equations work to describe it.

Put it on the list of institutions we need to restore after we win back power in a landslide. We need a plan.

No sunglasses next time. 😎

Yeah, I was all over that at that time.

Software was SO interesting to me as a molecular biologist that I switched careers to become an independent contract programmer, first in HyperCard (for Danny Goodman) and then for Microsoft and Apple…. Then DNA sequencing in C++ and Java.

You will, one way or another! Don’t worry about the job market. You will one day retire (like I have) and write an autobiography about your career.

A great example of a great scientific career autobiography is this: Noller, Harry F. “By Ribosome Possessed.” doi.org/10.1074/jbc.....

I prefer the metaphor of commercial truck driver. Physics is the law. Obey the rules of the road. Never make a mistake. Own or at least maintain your vehicle. Your precious cargo is not your own. As always, respect your community and they will respect you.

I used to visit his lab at UC Berkeley in the late 80’s. Collaborated with some of his group. Could never understand his arguments in print, and nobody would speak about it in the lab. Taboo subject.

Looks great!!

Immediate download! I’ll give it a try. Thanks and good luck.

I'm very impressed with this huge new topic, and the thinking behind it. Yes!!! I will be a user/contributor.

From Words to Worlds: Spatial Intelligence is AI’s Next Frontier In 1950, when computing was little more than automated arithmetic and simple logic, Alan Turing asked a question that still reverberates today: can machines think?

From Words to Worlds: Spatial Intelligence is AI’s Next Frontier
open.substack.com/pub/drfeifei...

Hats off, sir!

UMass Amherst Researchers Create Nanoparticle Vaccine That Prevents Cancer in Mice | UMass Amherst The vaccine also proves highly effective at preventing cancer’s deadly spread.

Check out this article: www.umass.edu/news/article...

I remember a visit by Chinese government officials in year 2000 to Incyte Genomics. They were interested in knowing how best to establish a thriving biotech industry with strong long-term innovation characteristics. They wanted to know what was most important and how to accelerate their industry.

Exactly what I said. I thought it was an April Fool joke.

Not necessarily. It just puts you in the crosshairs for a Cambridge Analytica style propaganda campaign designed to flip you to the dark side. Too many liberals going to the dark side is not “organic.”

Flipping all of that would take concerted effort. I used to think it was difficult to sell opposing views. Maybe it is easier than we know if there is a proven algorithm that can perform much work to engage and brainwash the targeted audience.

Statistically impossible unless there is some brain-washing going on.

I know people (even tech CEOs) are easily duped by propaganda and fear. But I also know that educated liberal people have strong beliefs in facts, law, science, and history and what is right and wrong. So…

Conjecture: Something must going on to “cause” that because 1. It takes a lot to get people’s minds changed, and 2. There is a lot of news and events flowing that objectively points to deception coming from the Trump right wing. To flip many liberals in this environment should be very difficult.

Cambridge Analytica proved it was possible to influence individuals and groups with targeted attacks by leading them on a synthetic emotional roller coaster designed to make them angry and question their beliefs. And to instill in them new beliefs.

Too many historically liberals are flipping.

@mbenioff.bsky.social I don’t know you directly, but i thought everything you stood for and believed passionately in (before the NYT article 10/10/25) and made many speeches about — you have flipped 180. Please explain.

I don’t know the man, but as far as I know everything he stood for and believed passionately and has many speeches about — he has flipped 180. How does that happen?? How could that happen?

Ice? Not Ice!

25 years ago, I led the development of software for human review of automated DNA sequencing projects at scale. Many genomes, many labs, fast and secure analysis. At Incyte Genomics. For HGRI and the Stanford human genome project.

I had this idea in 1979-80, and made a few notes of music from rrnB operon sequences back then when working in Harry Noller’s lab — one of the first DNA sequencing labs. We didn’t have any software back then. Proofreading was Jurgen and I reading it back to each other. I wanted music to help.

Not weird in a bad way.

Well, except Nick, here, being a “designer”.

Flowers “run” on algorithms of gene expression which is run on patterns in RNA-protein complexes responding to environmental cues. Precise microscopic mechanisms in a sea of chaos. Purpose and beauty emerging from randomness. No designer. Just physics and mathematics as “the rules.”

Nick: I encourage your work directions. Big fan.