Tick-borne viruses surge globally, driven by climate change and ecological shifts, challenging public health with rising infection complexity and control hurdles.
by Ye RZ, Li YY, Wang XY and Cao WC in Nat Rev Microbiol #MedSky
👉 get more here
📖 read the article:
Have you been waiting for a conference dedicated to Vector-Pathogen Interactions? Well you're in luck. Myself, Sarah Merkling, Flaminia Catteruccia, and Utpal Pal have organized the conference for you with an amazing lineup. Mark your calendars and share!
www.keystonesymposia.org/conferences/...
WE ARE RECRUITING PHD STUDENTS!!!
We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project.
#Drosophila #Evolution #Immunity #SelfishGene #Aphids
Thread with links below 🧵 1/4
what the actual hell, arbovirology
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Looking for an illustrator for a potential book project.
Historical anatomy textbooks are built on the bodies of prisoners, the poor and the powerless – and we’re still using them today.
In this hierarchical system, migrants are kept on extended probation and judged by standards never applied to British nationals.
“As human-driven climate change makes winters shorter, ticks are spending less time hibernating and have more active months when they can hitch rides on animals and people. Sometimes the ticks carry themselves — and diseases — to new parts of the country.”
Curious about tick virology? Read my latest piece in @uk.theconversation.com where I explain findings of my latest research article www.nature.com/articles/s41...
Hope it will helps people to understand the importance of studying tick and their pathogens #ScienceforAll #WomenInScience #Arbovirose
Only 2.5% of animal biomass is human.
Still, that fraction is reshaping the fate of the whole 🌍.
⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41...
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025
Infection and Immunity is now welcoming nominations for highly promising scientists at the assistant professor level (or equivalent) to submit research to the next New Voices in Microbiology Collection!
Please nominate by the August 18 deadline using the below link:
app.asm.org/account/logi...
SFTSV is a deadly tick-borne virus. In this study, Petit et al. used a multi-omics approach to reveal antiviral responses in SFTSV-infected tick cells
@virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social
@uniofsurrey.bsky.social
“Volume is a bad driver,” [Sir Mark Walport] said. “The incentive should be quality, not quantity. It’s about re-engineering the system in a way that encourages good research from beginning to end.”
www.theguardian.com/science/2025...
Thrilled (and humbled!) to share that since today I am the Chair of the Virology Department at @pasteur.fr. Grateful to my colleagues for their trust. Now let’s push the frontiers of virus research together. The sky is the limit! 🦠🔬 #Virology #Science #TeamPasteur
Come and join the @mossi-lab.bsky.social group! We have a postdoc position available on Wolbachia and Anopheles interactions.
app.vacancy-filler.co.uk/salescrm/Car...
The mere thought of ticks makes our skin crawl. And the diseases they spread are only getting more common. Here are some simple tricks for preventing tick bites and techniques for removing them if they do bite. nyti.ms/4jsK6Km
Finally A BIG THANK YOU to all my co-authors, they made this long journey started in 2021 a bit smoother! Thanks to Scaturro lab, Kohl lab, @brennanlab.bsky.social, @quangu.bsky.social, and Dundee proteomics! And of course thanks to the Tick cell Biobank and Lesley for those tiny cells!
Our strategy successfully identified two novel antiviral effectors: DHX9 and UPF1, both RNA helicases. While these proteins are known to participate in RNA detection and degradation, their precise mechanism of action against SFTSV remains unclear... Stay tuned for the next chapter! 🔍 #TickVirology
By integrating our omics layers, we generated a comprehensive snapshot of SFTSV infection. However, to identify factors crucial for SFTSV, biological validation was necessary. We performed knockdown of selected effectors in tick cells and tested their roles in SFTSV replication and infectivity.
Finally we finalized our omics characterization by looking at the interactors of SFTSV N protein during an active infection. N interactors were mostly related to stress, or RNA regulation pathways. We identified interactors conserved in human, and other associated with immune response to bunyavirus.
To understand our tick cell infection we focused on immune related pathways. We were able to map innate immune pathways (Jak-STAT, Toll, Imd). Interestingly little regulation was observed. Regulation was more important for stress-associated pathways suggesting a role in viral regulation.
Using this novel knowledge we studied the impact of SFTSV infection dynamics on tick cells. While the infection is asymptomatic in cells, we observed large change at 3 and 6 days post-infection. With little conservation of those changes overtime, suggesting large changes in infected cells.
Our first objective was to generate a better transcriptome and the first reference proteome for BME/CTVM6 tick cells. Following RNA and protein extraction, we performed proteomic informed by transcriptomic analysis. This approach brings insights into the molecular biology of our tick vector system.
Ticks are vector of many pathogens including hemorrhagic fever virus like SFTSV. Identified in 2009, SFTSV interaction with its tick vector remains understudied. To bypass limited understanding and tools available I used my system virology expertise to explore tick-virus interactions!
OMG! I can finally share my joy to see my SFTSV work published in @natcomms.nature.com! This adventure started by the award of my MSCA grant and my move to the Kohl and @brennanlab.bsky.social at @cvrinfo.bsky.social. Let's chat about how we discovered novel tick anti-viral effectors!
Calling all virologists: my lab is hiring a tech for high containment work! Come work with our amazing team at 🇨🇦's National Pandemic Research Centre, using experimental, systems biology, & AI-driven approaches to study infection & pathogenesis of emerging viruses.
