Miquéias Lopes-Pacheco

Frontiers | Extracellular vesicles from mesenchymal stromal cells as a promising therapy for ARDS: a systematic review of preclinical studies IntroductionMesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising cell-free therapeutic strategy for acute respirator...

Our new paper has been published: "Extracellular vesicles from mesenchymal stromal cells as a promising therapy for ARDS: a systematic review of preclinical studies" in @frontiersin.bsky.social in Medicine 👨‍🔬📚
#extracellularvesicles #ards #lungdisease #therapydevelopment

doi.org/10.3389/fmed...

#fbf #cysticfibrosis

🏆 I'm honored to share that, for the fifth consecutive year, I have been recognized among the Top 2% Cited Scientists worldwide, based on the list compiled by Stanford University using Scopus citation data. 👨🏻‍🔬🔬📊💊🫁

👉🏻 doi.org/10.17632/btc...

#biomedicalresearch #biochemistry #cysticfibrosis

I shared yesterday some work I have been conducting over the last few years... 🧑🏻‍🔬🧬🫁📚

#cysticfibrosis #cftrbiology #drugdevelopment #lifeinscience

@emory-choa-cfair.bsky.social

Our new paper has been published: "Building Lay Society Knowledge and Education for Health Technology Assessment and Policy Engagement: Case of CFTR Modulator Access in Brazil" in Healthcare @mdpiopenaccess.bsky.social 👨‍🔬📚
#cysticfibrosis #healthpolicy #advocacy

www.mdpi.com/2227-9032/13...

Highlights of 20 years of training and research... 📚🧑🏻‍🔬

#fbf #lifeinscience #phdjourney #cysticfibrosis

💜💚
unidospelavida.org.br/irmao-e-pesq...

Ending the month with a new milestone: 2500 citations 🧑🏻‍🔬

#scopus

Advancing cystic fibrosis treatment: investigational agents on the horizon Cystic fibrosis (CF) treatment has been transformed by CF transmembrane conductance regulator (CFTR) modulator therapies, yet significant gaps remain for those with non-responsive or modestly respo...

Our new paper has been published: "Advancing cystic fibrosis treatment:
investigational agents on the horizon"
in Expert Opinion in Pharmacotherapy 👨‍🔬🧬🔬🧫 💊

#cysticfibrosis #CFTR #CFTRmodulator #noveltherapeutics #precisionmedicine #pharmacology #genetherapy

www.tandfonline.com/doi/full/10....

First Cystic Fibrosis Conference I attended... 🧑🏻‍🔬🧬🔬

#fbf #2008 #oldbutgold #cysticfibrosis

Massive DNA sequencing effort reveals how colonization shaped Brazil’s genetic diversity New study identifies thousands of new variants related to diseases

💡Massive DNA sequencing effort reveals how colonization shaped Brazil’s genetic diversity | Science | AAAS
www.science.org/content/arti...

Being a CF brother and scientist has been a journey... not a fair one in many ways, but I always have this quote in mind:
"It is not how much we do, but how much love we put in the doing..." 💜

#cysticfibrosis #CFAwarenessMonth #addingtomorrows #justbreathe #CFwarrior #dumspirospero

"Each breath is a step closer to our dreams..." 💜

#cysticfibrosis #CFAwarenessMonth #CFAwareness #lifeinscience

💡

CF-AIR, CF@LANTA, and the CF Care Team had a great time on Saturday, May 17th supporting the Cystic Fibrosis Foundation's Great Strides Atlanta event! 💙

In the week of @cffgeorgiachapter Great Strides, we wear #65roses to celebrate #CFAwarenessMonth 🌹💜

#cysticfibrosis #cfawareness #fight4cure #justbreathe

Another Thursday celebrating the #CFAwarenessMonth 💜

#cysticfibrosis is part of who we are -- not the limit of who we can be!

#fight4cure #crossoutcf #cfawareness

🧬✍🏻

#cysticfibrosis #cfawareness #inkonskin #lifeinscience #cfawarenessmonth #cftr

The CF Brother Who Became a CF Scientist During CF Awareness Month, Emily’s Entourage invites members of the cystic fibrosis (CF) community to share their stories. Today’s blog post highlights the story of Miquéias Lopes Pacheco, PhD, a brot...

It has been a journey... Thanks, @emilysentourage.bsky.social for including me in the #CFAwarenessMonth campaign this year! 💜

#cysticfibrosis #fight4cure #cysticfibrosisawareness #crossoutcf

www.emilysentourage.org/the-cf-broth...

Here we are to celebrate another #CFAwarenessMonth as a proud brother of a #CFwarrior 🦾🧬

#cysticfibrosis #fight4cure #cfawareness #crossoutcf

Can Empathy Help You Be More Creative? A new study suggests that people who are good at seeing things from others' perspectives are more likely to be creative in everyday life.

“People who identify as being more empathic not only tend to be more creative, but may be more productive with their creativity, too” 💭
greatergood.berkeley.edu/article/item...

How do I explain the publication gap I ended up with after a hostile manager? A poor working relationship with a supervisor or manager can result in lost opportunities, creating an unexplained gap in an early-career researcher’s publication record.

www.nature.com/articles/d41...

Recent developments in cystic fibrosis drug discovery: where are we today? The advent of variant-specific disease-modifying drugs into clinical practice has provided remarkable benefits for people with cystic fibrosis (PwCF), a multi-organ life-limiting inherited disease....

Our new paper has been published: "Recent developments in cystic fibrosis drug discovery: where are we today?"
in Expert Opinion in Drug Discovery Taylor & Francis 👨‍🔬🧬🔬🧫 💊

#cysticfibrosis #CFTR #CFTRmodulator #noveltherapeutics #precisionmedicine
#multiomics

www.tandfonline.com/eprint/RNWZS...

13 years (and counting...) since my M.S. thesis defense. 🧑🏻‍🔬🫁

#lifeinscience #masterthesis #respiratorydiseaseresearch #silicosis #celltherapy

💭

Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease - PubMed Stargardt disease is the most common form of early onset macular degeneration. Mutations in ABCA4, a member of the ATP-binding cassette (ABC) family, are associated with Stargardt disease. Here, we ha...

#tbt #sciencefacts
In this #experimentalstudy, we demonstrated that certain #CFTRmodulators rescue misfolded variants in #ABCA4, a protein involved in macular degeneration. These may represent promising #therapeutics for #Stargard #eyedisease 🧑🏻‍🔬🧬💊
#drugdevelopment

pubmed.ncbi.nlm.nih.gov/26092729/

🧑🏻‍🔬✨

#scholargps #precisionmedicine #lifeinscience

Pilot safety study of intrabronchial instillation of bone marrow-derived mononuclear cells in patients with silicosis - PubMed NCT01239862 Date of Registration: November 10, 2010.

#fbf #sciencefacts
This #clinicalstudy was published in 2015 and demonstrated that infusion of bone marrow mononuclear cells via bronchoscopy is safe and well tolerated in patients with #silicosis 🧑‍🔬🔬🫁📊
#celltherapy #lungdisease #therapydevelopment

pubmed.ncbi.nlm.nih.gov/26059242/

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Our new paper has been published: "Cystic fibrosis: new challenges and perspectives beyond elexacaftor/tezacaftor/ivacaftor" in Therapeutic Advances in Respiratory Disease 👨‍🔬🧬🔬🧫 💊
#cysticfibrosis #CFTR #CFTRmodulator #noveltherapeutics #precisionmedicine

journals.sagepub.com/doi/10.1177/...