Jerome Epsztein

🧠 The hippocampus isn’t a one-way circuit. It’s a multilane system for learning & memory. Join us tomorrow to explore how parallel processing emerges from cell diversity.
📍MIN28 | Nov 18 | 9:30–12:00 | Rm 6B. Co-chaired with @flaviodonato82.bsky.social
#SfN2025 @SfNtweets

If you are interested I suggest reading the excellent review by David Robbe @davidrobbe.bsky.social, in which he acknowledges the pioneering work of the philosopher Henri Bergson, who introduced the concept of 'la durée' to distinguish between experienced and measured time doi.org/10.1016/j.ne...

Time, space, memory and brain–body rhythms - Nature Reviews Neuroscience Understanding how the brain represents experienced time and how representations of space and time are integrated to form episodic memories has been a goal of much neuroscientific research. In this Per...

The changes we experience may be the source of our subjective experience of time.
www.nature.com/articles/s41...

Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space https://www.biorxiv.org/content/10.1101/2025.11.14.688496v1

Characterizing neuronal population geometry with AI equation discovery The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...

1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...

The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events https://www.biorxiv.org/content/10.1101/2025.11.12.687961v1

Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex https://www.biorxiv.org/content/10.1101/2025.11.11.687899v1

Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here:
www.ucl.ac.uk/cortexlab/po...

A yr ago, I wrote a piece about what is becoming a quasi-obsession in neuroscience: internal models/representations. I’m kind of stuck and not sure what to do with it. Meanwhile, I came across 2 excellent "critical" papers on the same topic by @olivia.science and @smellosopher.bsky.social 🙏💪 :

REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce...

"NMDA receptors drive subthreshold depolarization specifically during REM sleep."

Nice ! Congrats !

#Caturday with Rita and Mitsu

I’m fluent ! thanks for sharing !

Grid cells accurately track movement during path integration-based navigation despite switching reference frames - Nature Neuroscience Grid cells do not maintain a stable pattern during a self-motion-based task, but track animal movement in multiple local reference frames and reanchor to task-relevant objects, thus estimating local r...

No GPS in the head? Path integration by entorhinal grid cells without the grid pattern. Interesting paper from Heidelberg. www.nature.com/articles/s41...

UN Says Emissions Will Drop In The Next 10 Years But Not ‘Fast Enough’—Bill Gates Urges New Approach The projections still fall short of the 60% reduction in emissions needed to prevent global temperatures from rising by more than 1.5 degrees Celsius above preindustrial levels.

The projections still fall short of the 60% reduction in emissions needed to prevent global temperatures from rising by more than 1.5 degrees Celsius above preindustrial levels.

Color-coded mean firing rate maps of place fields detected in the forth trials (left, sorted by the location of place fields peak) and back trials (right, sorted according to firing order in the forth trials) of all bidirectional cells recorded in the track with objects (top) or without objects (bottom). The color represents the intensity of the mean firing rate in a given bin normalized to the maximum mean firing rate (peak rate) in each direction. Note that in the CP condition, the mean firing map in one direction is the mirror image of the mean firing map in the other direction, indicating strong distance coding.

Happy to share our new paper with Mathilde Nordlund and Julie Koenig out @currentbiology.bsky.social. We used virtual reality in mice to study hippocampal distance coding. Our results suggest a primary contribution of grid cells to distance over cue-dependent place cell coding.
shorturl.at/63yFo

Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France » TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...

La @socneuro.bsky.social a publié avec plusieurs Sociétés savantes et Associations de patients une tribune dans Le Monde « Budget 2026 : La taxation des expérimentations animales mettrait en péril la recherche en France » : www.lemonde.fr/sciences/art...
#plf2026 @sneuroendo.bsky.social

Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex. https://www.biorxiv.org/content/10.1101/2025.10.27.684857v1

Congrats Marco and team !

Let’s use a good occasion to break my Bluesky shyness 😅 — a new article just came out!
This one goes back to data from the very start of my PhD, and I’m so happy to see it finally published 🧠

👉 onlinelibrary.wiley.com/doi/full/10.... 🧵1/5

A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations Classic theoretical models of cortical oscillations are based on the interactions between two populations of excitatory and inhibitory neurons. Nevertheless, experimental studies and network simulatio...

Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo

New preprint from Satoshi Kuroki & Sébastien Royer

Grid cells encode reward distance during path integration in cue-rich environments

www.researchsquare.com/article/rs-7...

Thanks !

Happy to see our recent work with @juliekoeniggambini.bsky.social on hippocampal distance coding featured in today’s issue of “La Provence” @inserm.fr @insermpacacorse.bsky.social @univ-amu.fr @inmed.bsky.social

Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted an...

Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island

www.science.org/doi/10.1126/...

We are happy to announce our new preprint:
“Slow Intrinsic Oscillations in the Ventrolateral Preoptic Nucleus”
We identify <1 Hz rhythmic bursting in #VLPO neurons that persists under TTX, revealing intrinsic oscillatory mechanisms that may shape NREM #sleep dynamics.
www.biorxiv.org/content/10.1...

Amazing work congrats !

I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.

doi.org/10.1126/sci...

With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others