Jerome Epsztein

Vectorized instructive signals in cortical dendrites - Nature Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.

This paper on how the brain may do gradient descent is very cool: www.nature.com/articles/s41...

Always a pleasure to have you around ! Looking forward to the next time !

How do we balance external attention to the outside world and internal attention to our thoughts & memories?

We review evidence that external and internal attention can compete, unfold concurrently, or cooperate!

Loved working on this with @samversc.bsky.social & @tobiasegner.bsky.social!

New preprint out 🎉

What happens to the hippocampal “place code” when an animal is actively engaged in a task?

The answer surprised us (and might surprise you too!).

Let's dive in ⬇️

Link:
"Hippocampal trace coding dominates and disrupts place coding" www.biorxiv.org/content/10.6...

Place cells in CA1 lack topographical organization of firing locations | PNAS Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...

Un événement à destination des patients, familles et associations de patients.

New preprint from the lab! Stefan Sun and @q-perrenoud.bsky.social collaborated to look at how sensory experience affects the adult cortex. Using ephys and 2-photon imaging, they found that varied visual experience reorganizes dendrite-targeting inhibitory circuits in V1.

👀👇

Great opportunity 👇

🚨 new work from the lab on how eye movements 👀 versus orofacial movements influence 🐭 visual cortex activity 🧠 #neuroscience #behavior #neuroAI

Ruban violet, symbole de la Journée internationale de l’épilepsie, sur fond clair.

🧠 𝗝𝗼𝘂𝗿𝗻𝗲́𝗲 𝗶𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹𝗲 𝗱𝗲 𝗹’𝗲́𝗽𝗶𝗹𝗲𝗽𝘀𝗶𝗲 – 𝟵 𝗳𝗲́𝘃𝗿𝗶𝗲𝗿

À l’AP-HM, cette journée est l’occasion de rappeler l’importance de l’information, du diagnostic et de l’accompagnement des personnes vivant avec une épilepsie, ainsi que de leurs proches.

Really excited by this awesome work from @abrate.bsky.social TDLR - in self supervised predictive models policy really affects representations. If you use policy extracted from rats of different ages the representations that emerge mirror those in the rats.

Latest issue is out!
www.cell.com/current-biol...

Rather than a charismatic cow, this time we feature a cryptic beauty & unsung hero —the detritivore— vital for soil-related ecosystem function.

An orange springtail, devouring detritus in its native edaphic habitat. 👉 www.cell.com/current-biol...

The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉
www.biorxiv.org/content/10.6...
🧵(1/6)

Les premiers rendez-vous de l'édition 2026 de la Semaine du Cerveau sont en ligne ! 🤗

Découvrez le programme : www.semaineducerveau.fr/programme-ma...

#SDC2026

Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal com...

Coincidence of thalamic HD signal and retrosplenial visual input is detected in the Presubiculum! 🎯 This may be the neuronal basis for landmark anchoring of the HD signal. Pleased to announce the VOR is now available elifesciences.org/articles/92443 Congrats first author Louis Richevaux 🙌

Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...

🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9

PhD position(s)🚨deadline 20th Jan

1-development of brain & behaviour in the precocial spiny mouse tinyurl.com/yaxhy5y2
2-social behaviour & neurophysiology in a menstruating rodent using AI tinyurl.com/ykv93cts

apply ✍️

@ai4bicdt.bsky.social @sidb-edinburgh.bsky.social @edinunineuro.bsky.social

Congrats JB and all co authors ! Very cool paper !

2025: A Review of the Year in Neuroscience Enlightening the brain

Just published my review of neuroscience in 2025, on The Spike.

The 10th of these, would you believe?

This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more

Enjoy!

medium.com/the-spike/20...

Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

⚠️ New paper alert and what a way to end 2025! 🎉
Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.

Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8

Axon initial segment dynamics during associative fear learning - Nature Neuroscience Benoit, Ganea et al. show that changes in axon initial segment (AIS) length in the prefrontal cortex of mice accompany fear learning and extinction, revealing AIS plasticity as a key feature of neuron...

New study on axon initial segment plasticity by Chloé Benoit and Dan Ganea. Using a deep brain imaging approach, we find that AIS length changes dynamically during associative learning. Thank you to the wonderful team and collaborators who made this work possible. www.nature.com/articles/s41...

Examples of sequences of activity seen in multiple regions of the brain

Sequences are everywhere! In every brain region. And are written in stone.

Invariant Activity Sequences Across the Mouse Brain.

Out today, by Célian Bimbard, with @kenneth-harris.bsky.social.

Based on data by Célian and by @intlbrainlab.bsky.social.

www.biorxiv.org/content/10.6...

Souhaitons tous un excellent anniversaire à l'ethno-historien et géographe Jean #Malaurie, né le 22 décembre 1922 et décédé l’année dernière. Fondateur de la collection littéraire Terre Humaine, qu’il inaugura avec son récit Les Derniers Rois de Thulé, aux Éditions Plon.

It’s this time of the year again

Le soleil ? 🤔

What is a 🧠 ripple? See our @cellpress.bsky.social perspective on ripple diversity and the grammar of memory replay: connecting key pieces from current work across the field. 👉🏼 www.sciencedirect.com:5037/science/arti...

We invite applications for postdoctoral researchers with strong expertise in in vivo electrophysiology and circuit neuroscience to join our team at the Paris Brain Institute (ICM).

Amazing ! Congrats Antoine ! Looking forward to the science that will come out of you lab !

Happy to announce the 2nd Hippocampus Green Meeting
📍 Barcelona, Spain
🗓️ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎤 Keynotes: Nachum Ulanovsky & György Buzsáki
‼️ Call for abstracts now open
🔗 hippocampusgreen.net/wp/
#HippocampusGreen