Axel Olin

I understand that a high prediction accuracy reveals some connection between the variables and that it can be used to identify the most strongly associated omics variables.

Still, it feels so backward to me. I don't need to do a bunch of omics to figure out how old I am. 🫠 2/2

In exploratory omics studies in humans, it is quite common to evaluate the prediction accuracy of demographic variables like age and sex using the omics variables.

In what situation would you actually need to do this? Isn't there some more natural statistical framework that makes more sense? 1/2

75% is insane. Government loans for scientific funding would be a crazy good investment for countries that can afford it.

13 chair positions open @inserm.fr to lead a junior research group in France covering #neuroscience, #immunology, #bioinformatics, #bioengineering, #biotherapy, #public health pro.inserm.fr/rubriques/co... 🧪🔬

Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology - BMC Biology Although variation in effect sizes and predicted values among studies of similar phenomena is inevitable, such variation far exceeds what might be produced by sampling error alone. One possible explan...

My sister was involved in a similar study in ecology. Even with a relatively simple dataset and guided by a research question, results were all over the place and did not correlate with reviewer assessment. I don't have high hopes for exploratory omics studies...

link.springer.com/article/10.1...

A tweet from Trump that reads “All Federal Funding will STOP for any College, School, or University that allows illegal protests. Agitators will be imprisoned/or permanently sent back to the country from which they came. American students will be permanently expelled or, depending on on the crime, arrested. NO MASKS! Thank you for your attention to this matter”

ahhhhhhhhhh

The best thing Americans can do right now is minimizing domestic spending and donating to Ukraine: u24.gov.ua

Europeans should also donate more, stop buying american, invest in EU defense stocks, and pressure their governments to donate more and ramp up defense spending.

Complete batshit lunacy on the president's Truth Social account. Yes, he really posted this.

Today, the US stood with Russia and North Korea — and against our allies — in voting against a UN resolution to condemn Russia's aggression against Ukraine. Let that sink in.

This is a betrayal of the Ukrainian people, our allies, our interests and those who aspire for freedom.

Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.

It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.

As an update, I think the account has now been wiped, but there is plenty of evidence of previous posts online.

Obviously, that doesn't matter. Considering Musks previous meddling with German politics and the fact this happened on the day of the German election, it is clear this was no accident.

Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.

It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.

From the law community on Reddit: The full Executive Order is out! ⚠️ This is the biggest executive power grab in U.S. history. ⚠️ Explore this post and more from the law community

www.reddit.com/r/law/commen...

US going full dictatorship quickly.

Nice recipe! What type of tequila are you using?

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:

357 validated out of 1,124 tested.

.

This guy is a xenophobic right-wing lunatic, unfortunately. There are plenty of other reasons to be proud though! :)

Here's our latest work on proteome profiling of self-sampled dried blood spots to gain insights into the heterogeneity of the immune response against infections and vaccinations. We enrolled random citizens by postal mail to learn more about the molecular effects beyond those seeking medical care.

🩸🔬 Introducing #CryoSCAPE, a groundbreaking technique that keeps blood cells alive in deep freeze. This innovation promises to expand the reach of cutting-edge single-cell technologies to rural or underserved populations. ✨ 🧵

#SingleCellTech #RNAseq

‼️‼️

Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden

More info on how to apply below (please RT)

Trump just casually hinting that territories of allied countries might have to be incorporated into the United States because of 'national security'.

I remember thinking about which protein name has the longest fully expanded name. The longest I came up with then was TBK1, equaling:

Tumor necrosis factor receptor-associated factor family member-associated nuclear factor kappa-light-chain-enhancer of activated B cells activator-binding kinase 1

Very cool study! I'm looking forward to seeing results for other pathogens, as you hint at below.

Have you only tried this with adult mice so far? I would be interested to see how this phenomenon relates to age.

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8

I demand that every study that uses fecal samples be renamed from a "gut microbiome" to "fecal microbiome" study, including in the title. Thus, researchers would have to focus on good study design rather than sensationalism. Stool samples are NOT representative for the gut.

I am excited about Pixelgen Technologies molecular pixelation assay for single cell spatial proteomics. They have a new new tech note out in collab with #illumina www.illumina.com/content/dam/...

Preprint servers enabling these types of solutions as an alternative to PDFs would be a significant first step. The issue is that if the big publishing houses don't adopt it, it will essentially eliminate any chances of publishing it.

Curvenote | Scientific publishing infrastructure Curvenote develops next-generation publishing infrastructure and writing tools to support open, reproducible research. A beautiful writing tool designed for technical writing, connected to Jupyter. Wr...

These types of solutions look very interesting for scientific publishing: curvenote.com

Producing manuscripts (especially figures) suck due to the poor software available. Reading is an equally terrible experience, having to zoom in on figures and scroll up and down to look at references.

I think issues arise when institutional/job/grant review boards actually DO care about them and use their publication/citations as a metric for scientific productivity.

When such AI use is blatant, it should be considered scientific misconduct, almost on the level of fabricating results.

I created a starter pack for systems immunology - let me know if you would like to be added. Excited to be here on
@bsky.app

go.bsky.app/PjH2Fuj