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PEnghard

@penghard.bsky.social

Nephrology and Intensive Care Medicine

1,124 Followers  |  1,129 Following  |  39 Posts  |  Joined: 01.11.2023
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Posts by PEnghard (@penghard.bsky.social)

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Very cool paper from Hamburg! Urinary CD4+ T cells identify SjΓΆgren's patients with nephritis and help monitor treatment response! Awesome work!

pubmed.ncbi.nlm.nih.gov/41673408/

#NephSky

28.02.2026 05:38 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Description of a prescription cascade, when an initial prescription for pregabalin or amlodipine causes leg oedema leading to addition of furosemide which causes urinary incontinence. This leads to a RX for Solifenacin which causes cognitive decline and a prescription for Don Pascale. The subsequent anorexia and an insomnia leads to mirtazapine prescription and a hip fracture from a fall. This of course leads to many other cascades, including delirium, haloperidol and levodopa, risedronate, and pantoprazole, or iron and constipation with peg.

Description of a prescription cascade, when an initial prescription for pregabalin or amlodipine causes leg oedema leading to addition of furosemide which causes urinary incontinence. This leads to a RX for Solifenacin which causes cognitive decline and a prescription for Don Pascale. The subsequent anorexia and an insomnia leads to mirtazapine prescription and a hip fracture from a fall. This of course leads to many other cascades, including delirium, haloperidol and levodopa, risedronate, and pantoprazole, or iron and constipation with peg.

From @carolyntan.bsky.social

This is a work of art

Have to agree that amlodipine and gabapentin/pregabalin often lead to heart failure misdiagnosis

#MedSky #PharmSky

h/t @davidjuurlink.bsky.social and @jbrianbyrd.bsky.social

04.11.2025 23:31 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 3    πŸ“Œ 0

Wow! Excellent Flow Chart… could also end with β€žnever again getβ€˜s back to normalβ€œ!

05.11.2025 01:08 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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With great collaborators from CharitΓ© Berlin, the university hospitals in MΓΌnster, Essen, and Hannover, Evangelisches Klinikum Bethel Bielefeld, and St. Joseph Hospital Berlin – such a pleasure working with such a great team!
Link to our study protocol: pubmed.ncbi.nlm.nih.gov/40473280/

19.10.2025 18:41 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We’ve just initiated the final center change in our stepped-wedge Sweet-Water trial! Aiming to include approximately 4,500 patients by the end of the year β€” we’re extremely curious to see what we’ll find out. Should Glucose 5% be the universal drug solvent? #nephsky #nephrology #IntensiveCare

19.10.2025 18:35 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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It was a pleasure organizing our 5th course on Intensive Care Nephrology together with Nicole Bethke, Martin Kuhlmann and the Akademie Niere. Inspiring lectures and an outstanding group of participants! #nephsky #nephrology

16.10.2025 06:40 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Fortbildung β€žNephrologische Intensivtherapieβ€œ der Akademie Niere vom 13.–16.10.2025 in Berlin.
Modul 1: konservative Intensivmedizin
Modul 2: Nierenersatzverfahren
Beide Module auch einzeln buchbar. Es sind noch PlΓ€tze frei! Infos & AnmeldungπŸ‘‰ www.akademie-niere.de
#Nephrologie #Intensivmedizin #CKD

30.09.2025 13:51 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Honored and grateful for this recognition of our work on immune monitoring and the urine microbiome in kidney transplantation – a great team effort! @penghard.bsky.social @janklocke.bsky.social & Andrey Kruglov

15.10.2025 14:48 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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#BookSky

19.07.2025 08:15 β€” πŸ‘ 39136    πŸ” 7771    πŸ’¬ 539    πŸ“Œ 526
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The sodium burden in ICU patients is off the charts! In an effort to bring about change, we’ve designed the Sweet-Water Trial β€” so excited that it’s up and running! #Nephrology #IntensiveCare #MedSky

DOI: 10.1136/bmjopen-2024-097361

17.06.2025 06:22 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Could we have more #ccr25 content on Bluesky please?

While I still have access to the other place, it’s not much fun seeing random X crap in between thoughtful takes about the utility of NFL

11.06.2025 10:47 β€” πŸ‘ 25    πŸ” 8    πŸ’¬ 4    πŸ“Œ 0

If you still have questions, come say hi after the session!

05.06.2025 09:52 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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…sometimes it feels like such a privilege working here! #CharitΓ©

13.05.2025 09:48 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Europe - still my favorite place on Earth:)

β€žSurvival in the wealthiest U.S. quartile appeared to be similar to that in the poorest quartile in northern and western Europe.”

www.nejm.org/doi/full/10....

07.04.2025 19:27 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

impressive! I have so far only seen this in a mouse model collegues had worked with

28.03.2025 20:28 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Susan Quaggin kicks off the first joint symposium between @MayoClinic & @ChariteBerlin: The Golden Age of Kidney Health. A milestone for innovation & collaboration in kidney research! #Nephrology #KidneyHealth #MayoCharitΓ© (foto by Thomas Rafalzyk)

21.03.2025 08:33 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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…looking forward to exiting Nephrology talks from Mayo Clinic and CharitΓ© at our first joint symposium! #nephsky #charite

21.03.2025 06:12 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

…this is such a cool paper by my favourite immunologists from DRFZ and CharitΓ© Berlin!

13.03.2025 13:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I am sure the NIH is/was the most important funder worldwide; nevertheless, these numbers seem odd - the European Union spent more than 388 million in 2022 on biomedical research!

10.03.2025 19:23 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Stacked area chart showing the cumulative number of preprints indexed by Europe PMC from 2020 to 2025. The x-axis represents the years, while the y-axis represents the cumulative number of preprints, reaching over 900,000 by 2025. Different colours represent various preprint servers, including Research Square (largest share), bioRxiv, Preprints.org, medRxiv, PsyArXiv, Authorea Preprints, SSRN, and Others. The chart highlights the steady growth of preprint publications over time.

Stacked area chart showing the cumulative number of preprints indexed by Europe PMC from 2020 to 2025. The x-axis represents the years, while the y-axis represents the cumulative number of preprints, reaching over 900,000 by 2025. Different colours represent various preprint servers, including Research Square (largest share), bioRxiv, Preprints.org, medRxiv, PsyArXiv, Authorea Preprints, SSRN, and Others. The chart highlights the steady growth of preprint publications over time.

Looking for the latest preprints in the #LifeSciences ?

Europe PMC indexes content from 24 #preprint servers, including bioRxiv, Research Square, medRxiv and more!!

πŸ”Ž Start exploring over 907,000 preprints in one database: europepmc.org/search?query=SRC%3A%2a%20AND%20%28SRC%3APPR%29&page=1

28.02.2025 13:54 β€” πŸ‘ 22    πŸ” 16    πŸ’¬ 0    πŸ“Œ 0

This works in case pubmed stays down… and it looks like a cool alternative anyway! #nephsky #science

europepmc.org

02.03.2025 07:51 β€” πŸ‘ 28    πŸ” 17    πŸ’¬ 0    πŸ“Œ 0

also has not been working for me for the last 12h… scary thing, also that it suddenly seems so possible that it might have been shut down

02.03.2025 04:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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CKD-Safari! Looking at kidney biopsies of elephants and dogs at the Kandy veterinary department in Sri Lanka! #Nephsky

24.02.2025 16:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Flow-Cytometric Quantification of Urine Kidney #EpithelialCells Specifically Reflects #TubularDamage in Acute Kidney Diseases #AKD

#VisualAbstract by @DrPSVali

www.kireports.org/ar...

@penghard.bsky.social @jan.klocke@bsky.social

21.02.2025 15:00 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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In addition to reporting a biomarker, our protocol provides a foundation for deeper analysis of urinary TECs. Together with Leonie Wagner, @ninagoerlich.bsky.social, @janklocke.bsky.social, and many others!
#NephSky

03.02.2025 20:36 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Flow-cytometric quantification of urine kidney epithelial cells specifically reflects tubular damage in acute kidney diseases Despite tubular injury being one of the main mechanisms driving acute kidney injury (AKI), clinicians still have a limited diagnostic repertoire to precisely monitor damage to tubular epithelial cells...

Happy to announce that this is out! A flow cytometry-based quantification of urinary kidney tubular epithelial cells (TECs) as a biomarker for kidney damage in AKI and ANCA vasculitis.

www.kireports.org/article/S246...

03.02.2025 20:35 β€” πŸ‘ 13    πŸ” 5    πŸ’¬ 2    πŸ“Œ 2

Same thoughts here, but I am torn. I assume (hope) that most nephrology colleagues are not fans of the current U.S. administration. However, by boycotting KW, would we be weakening those whom we ought to support? And which congresses could we attend instead? Certainly not ERA-EDTA in Austria...

02.02.2025 06:57 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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CDC Data Are Disappearing The agency has already removed scientific data from public view. More could follow.

…very disturbing, data seems to be disappearing from the CDC websites

www.theatlantic.com/health/archi...

01.02.2025 07:06 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

…pubmed still works in Europe

28.01.2025 20:36 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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OMG! Any details from the collegues in the US? Fingers crossed that the NIH funding will be continued very soon! NIH has made a huge difference for nephrology and medicine and is so important for our field! #NephSky

www.nature.com/articles/d41...

25.01.2025 07:10 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0