Dr. Mouse

A “response” to their Supreme Court issuing a ruling after due process. It isn’t enough that have destroyed the integrity of our Supreme Court. Now they arrogate to themselves the power to demand that the high court in other nations subvert the rule of law as well.

This is insane.

Typical USA. Not enough to destroy their own democracy, they gotta do it to other countries trying to get up on their feet. Crazy. We live in a world where China became the voice of reason and moderation.

How to be a scientist in a post-journal world When we created this site to write about things in science that need to be fixed, we chose not to start with publishing, even though it has been our preoccupation for decades.

Check out the latest from Mike and I on how to be a scientist in a post-journal world
9/9

thescientistpapers.substack.com/p/how-to-be-...

I strongly suggest that academic publishers cease to exist.

A paywalled article from @nature.com bemoaning the exploitation of scientists' unpaid labour. Chef's kiss. Perfection. No notes.

The fact that Oded is still heralded as a scientific leader says all you need to know about science IMO.

While journal publishing has always been deeply problematic, hurting both the pace and trajectory of science, something is happening in this moment that is finally causing the system to crumble under its own weight and cost.
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What a shortsighted take. Crypto is bigger than Trump. The dumbass is only interested because he wants to make more easy money for himself and his friends. That is all he cares about.

Pretty sure we will not know the cause for autism in September but I have a great hypothesis for the dramatic increase in morbidity due to infectious disease THAT COULD HAVE BEEN TOTALLY HANDLED BY FOLKS WHO ARE NOT BATSHIT CRAZY

MAKE AMERICA HYPERVENTILATE AGAIN

America Tips Into Fascism Today is different than before.

...

Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities

Tragic to see the U.S. brought to its knees, as the elites either retreat into their shells or bask in the fabricated blinding sun of self-praise.

Accurate and scalable multi-disease classification from adaptive immune repertoires
www.biorxiv.org/content/10....

Maybe you got only 3'UTRs and not introns bc drosophila introns are too small so you're dealing with a biased coin toss. Great opportunity to shift towards a furry cute mammal model that will drown you in paperwork and leave you bankrupt! ;)

not an expert but: occasional intron retention as a mechanism for antisense capture of these guys? Intron retention higher in germ cells (evolutionary benefits to expose sneaky TEs hitchhiking euchromatin?) + offer a sorting mech for mRNAs via weird spliceosome, NMD, or ribosome engagement or else.

Repeat after me: we. do. not. need. journals.

That said: after autoclaving the printed ones, they do give some nice nesting material.

"At no other time in modern history has a country so throughly turned its back on its core national strengths."— @vermontgmg.bsky.social
Gift link
www.nytimes.com/2025/08/12/o...

The silence of opposition in the US is hard to believe.

cannot argue with that. you all work for the corporations that manage to hijack science while profiting from its work AND convincing scientists that what you provide is the best proxy for career success. Masterclass in Stockholm syndrome.

“These creatures you call mice you see are not quite as they appear, they are merely the protrusions into our dimension of vast, hyper-intelligent pan-dimensional beings.”

I am just going to leave this here. But what a bunch of egocentric crap huh?

Not a new idea, but the level of demonstration seems unparalleled thanks to the power of Drosophila genetics. Congrats on the published paper! When learning about TEs for the first time, we are all dead scarred of insertional mutagenesis in genes, but maybe that is exactly what the genome wants.

Show me an editor with any sense of foresight, I will show you a talking mouse or a unicorn.

Well, the real surprise is why is it not 100%. Why would any one want to set foot in the USA is beyond the comprehension of even the smartest mice out there.

oh is tourism down across the board in the united states, that’s crazy

our new slogan “we will throw you in a fucking prison camp” doesn’t seem to be gaining traction with the tourism sector

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...

Highlights below!

I'd start a movement to get rid of all toxic mRNA in your body once and for all: ask your GPs or therapists for daily IV infusions of actinomycin D, or a more effective single dose IV of α-Amanitin. I am only a mouse, no MAGA listens to me. Spread the word!

Quintessential Stockholm syndrome: the relationship between scientists and scientific publishing companies.

Believe me, I would know. I mean, I love the caretakers of our facility. 100% sure I will never end in one of those black trash bags they sometimes carry out of the room.

RFK Jr. wants to finally ban the mRNA poison. I did my own research to help!

I have the solution for the great MAGA people and RFK Jr.: ask your therapists for daily IV infusions of actinomycin D, or a more effective IV of α-Amanitin.

#stopmRNA #mRNA #NOmRNAinMAGA #spreadtheword #MAGA

I spent 6 years getting my PhD in immunology, only to be told I now need 47 forms, 3 ethics reviews, and a Zoom call with a goat to run a basic inflammation study.

At this rate, humans will cure aging after I’m dead of natural causes.
#LetMiceDoScience 🐭📉