Pam Brigleb

Up to 30% of commercial pasteurized milk in US is PCR +Ve. Pasteurization inactivates virus, but HA protein preserved. In mice, repeated oral exposure to inactivated virus did not alter mortality or worsen disease after H5N1 virus challenge.
👉 www.science.org/doi/10.1126/...

St. Jude Children’s Research Hospital has been ranked among the top 10
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.

Read more: ow.ly/HNLN50X7PsR

Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection H5N1 influenza virus in pasteurized milk does not alter immunity in mice, suggesting limited health risks from consumption.

#H5N1 #OneHealth #Influenza #Zoonoses

References
Brigleb et al., 2025. doi.org/10.1126/scia...
Clessin et al., 2025. doi.org/10.1038/s414...
Dhakal et al., 2025. doi.org/10.1016/j.jf...
Kim et al., 2025. doi.org/10.1126/scia...
Palma, 2025. doi.org/10.3390/biol...
10/10

Thank you Reini! Hope you are doing well.

Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection H5N1 influenza virus in pasteurized milk does not alter immunity in mice, suggesting limited health risks from consumption.

Super excited that our paper @ssclabquips.bsky.social is out in #ScienceAdvances (@science.org)! --> Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection | Science Advances www.science.org/doi/full/10....

Inactive H5N1 influenza virus in pasteurized milk poses minimal health risks Proteins and genetic material from H5N1 influenza viruses have been found in pasteurized milk in the United States, but a study from St. Jude Children's Research Hospital shows those inactive viral pieces represent little to no health risk.

Pasteurized milk containing inactive H5N1 viral components poses minimal health risk and does not alter influenza immunity, while unpasteurized milk remains a significant health concern. doi.org/g94636

Super excited to see our study out in #ScienceAdvances today, summarized nicely by @stjuderesearch.bsky.social !

CDC Report & Risk Assessment On Potential Influenza Infection Via GI Tract #18,865 One of the topics we've touched on repeatedly over the past twenty years has been the - as yet, unquantified - risks of preparing, ...

AFD Blog `CDC Report & Risk Assessment On Potential Influenza Infection Via GI Tract' #H5N1 afludiary.blogspot.com/2025/09/cdc-...

Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines.

When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.

New review on antiviral approaches targeting lipids, written by one of our society members.

www.sciencedirect.com/science/arti...

In Vivo Imaging and Tracking of VRE-Microbiota Interactions via Anaerobic Fluorescent Reporters in Extremely Drug-Resistant Bacteria https://www.biorxiv.org/content/10.1101/2025.02.08.637206v1

Save NIH and NSF Research Funding ⭑ 5 Calls On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …

A useful tool and a great thing to do...

5calls.org/issue/nih-ns...

NIH cuts indirect rates on grants to 15%.

This will be the end of American excellence in science.

Universities will struggle and many (likely most) will terminate their research programs.

Independent research institutions will not be able to survive this.

grants.nih.gov/grants/guide...

In a new study by Simonson, @joanneflynn19.bsky.social et al., antibody depletion of select lymphocytes in rhesus macaques demonstrates key roles for CD4+ T cells and CD8α+ lymphocytes in conferring sterilizing immunity against #tuberculosis following i.v. BCG vaccination. https://buff.ly/4gxWbfR

Check out the newest preprint from the Schultz-Cherry lab on susceptibility of primary cells to H5N1 clade 2.3.4.4b viruses! -->

Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses https://www.biorxiv.org/content/10.1101/2025.01.09.632235v1

Very preliminary starter pack
Only about 25-30 on there so far

go.bsky.app/7zMmwNY

Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍

Sign of the times, no more bluebird on the biorxiv engagement tab..

Would love to join, thanks!

The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular understanding of the multiple killer-cell i...

Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology
www.cell.com/trends/immun...

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Adipose tissue retains an epigenetic memory of obesity after weight loss @vonmeyennlab.bsky.social
www.nature.com/articles/s41...

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬

A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.

go.bsky.app/AjNpW2h

Would love to be included, thank you!

Please add me if possible, thank you! 😊

The H5N1 sequence found in the hospitalized teenager shows two important mutations that improve the virus's ability to bind to human α2,6 sialic acid receptors.

This adaptation is crucial for the virus's potential to spread between humans.

The virus is evolving.

#H5N1

Tell me again how the H5N1 cattle outbreak is on its way to being contained.

An increased wastewater signal usually doesn’t suggest fewer cases.