Anja Groth

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...

This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social‬) and single-molecule data (Richard Janissen).

Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

Amazing accomplishment 👏👏 congrats Hiten and team 🎉

Excellent advice!!

Integrative modelling of biomolecular interactions Experimental structural studies of interactions can be costly, low-throughput, and challenging. Therefore, computational methods aiming to model protein complexes are particularly valuable. The accur…

From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025

Deadline: 15 June

meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪

Congratulations 🎉

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

⏰🚨FINAL DEADLINE APPROACHING

#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!

Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells!

Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...

#Genomics #VirtualSeminar

One more appointment with great science in a few days, one click away 👇

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL

The freedom to choose your own research focus – People – EMBO Meet Tuncay Baubec, Professor at Utrecht University | Former EMBO Young Investigator and EMBO Postdoctoral Fellow

Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities

Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....

In science we trust? EMBL Science and Society Conference

Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org

Hana Polasek-Sedlackova

Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social

In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...

Low overlap of transcription factor DNA binding and regulatory targets - Nature A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...

To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.biochemistry.org/events-and-t...

Dr Peter Marks, "Vaccines have been studied very extensively for being potentially associated with autism"

"That theory has been debunked"

"One study in Denmark, over 600,000 children. It shows that if anything, children had a lower rate of autism than unvaccinated children"

This is really great. Congratulations to @guijacquemet.bsky.social and all authors.

#PaperThemeTune can be anything from the atypical album Milijard by Circle, who are Finnish and also really great.

2025 VAI Epigenomics Workshop Join us for 2025 VAI Epigenomics Workshop at Van Andel Institute Stay informed about exciting upcoming events and activities.

The VAI Epigenomics Workshop is a great opportunity for #PhD students to learn the latest techniques from internationally recognized #epigenomics experts!

🗓️ July 29–31, 2025
📍 Van Andel Institute
👇 Learn more and apply