JonathonCArnold

Preclinical Evidence for a Drug–Drug Interaction Between Cannabinol and Melatonin The worldwide legalization of medicinal cannabis has led to an increased use of products made by commercial operators. These products often contain minor cannabinoids such as cannabinol (CBN) which a...

Paper out: #cannabinol (CBN) and #melatonin products are on the #cannabis market; here in mice we show #CBN increases the oral bioavailability of melatonin via an interaction at CYP1A2.

A high seizure burden increases brain concentrations of specialized pro-resolving mediators in the Scn1a+/- mouse model of Dravet syndrome Dravet syndrome is a severe, intractable epilepsy in which 80 % of patients have a de novo mutation in the gene SCN1A. We recently reported that a hig…

Collab with Johnathan Arnold’s group at U Sydney - High seizure burden increases brain concentrations of specialized pro-resolving mediators in #Scn1a #Dravet mouse model 🧠🧪🧬

Preclinical Evidence for a Drug–Drug Interaction Between Cannabinol and Melatonin The worldwide legalization of medicinal cannabis has led to an increased use of products made by commercial operators. These products often contain minor cannabinoids such as cannabinol (CBN) which a...

Another collab with Johnathon Arnold’s group at U Sydney - Preclinical Evidence for a Drug–Drug Interaction Between Cannabinol and Melatonin. Combination #melatonin/#cannabinoid sleep-aid products are in the market. This may explain why they work, but also suggests caution may be warranted. 🧪😴 💊

Preclinical Evidence for a Drug–Drug Interaction Between Cannabinol and Melatonin The worldwide legalization of medicinal cannabis has led to an increased use of products made by commercial operators. These products often contain minor cannabinoids such as cannabinol (CBN) which a...

Paper out: #cannabinol (CBN) and #melatonin products are on the #cannabis market; here in mice we show #CBN increases the oral bioavailability of melatonin via an interaction at CYP1A2.

'Sleepy cannabis': first objective study to show cannabinol increases sleep Research at the University of Sydney Lambert Initiative shows that a non-hallucinogenic component of cannabis - cannabinol - increases both REM and non-REM sleep in rats. Human trials are now under wa...

Cannabinol (CBN) is found in aged #cannabis, as it is an oxidative metabolite of THC. #CBN has been long speculated to increase sleep; here we provide evidence in rats that this is the case using objective measures.

👉Paper: doi.org/10.1038/s413...

👉Presser: www.sydney.edu.au/news-opinion...

'Sleepy cannabis': first objective study to show cannabinol increases sleep Research at the University of Sydney Lambert Initiative shows that a non-hallucinogenic component of cannabis - cannabinol - increases both REM and non-REM sleep in rats. Human trials are now under wa...

Cannabinol (CBN) is found in aged #cannabis, as it is an oxidative metabolite of THC. #CBN has been long speculated to increase sleep; here we provide evidence in rats that this is the case using objective measures.

👉Paper: doi.org/10.1038/s413...

👉Presser: www.sydney.edu.au/news-opinion...