Dr. Connor Haggarty

It was a great day @westernu.ca, and such an honor to be selected by students for the Treva Glazebrook Lecture. Thank you, Kendra Loedige, for being a wonderful host. Great to see you and catch up, @drjkhokhar.bsky.social - thanks for teaching me about academia in Canada. 🤩🇨🇦

💫Convergent evidence from 3 studies: amygdala-targeted neurofeedback produced large, dissociation-specific improvements in #PTSD - a step toward new treatments for #depersonalization and #derealization! tinyurl.com/bdsjnzrd

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You know finalising the grant is serious when I have the "piano chill" music playing

The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults - Psychopharmacology Rationale Stimulant drugs such as methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) can impact neurobiological systems implicated in stress, reward processing, and drug use. Although recent preclinical evidence implicates the endocannabinoid (eCB) system in these processes, little is known about the acute effects of stimulants on eCB levels in humans. Objectives The aim of the present study was to investigate the effects of acute administration of the prototypical psychostimulant MA and the psychostimulant-empathogen MDMA on circulating eCB levels in healthy adults. Methods Using a within-subject, double-blind design, this study assessed the acute effects of MA (20 mg), MDMA (100 mg), and placebo on plasma eCB levels in healthy human participants (N = 22) during three separate sessions. Blood samples assessing concentrations of the eCBs anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) were collected between 150- and 180-minutes post-drug administration, and subjective measures of drug effects were collected at regular intervals. Results MA, but not MDMA, was associated with significantly lower 2-AG plasma concentrations compared to placebo. Neither drug impacted AEA concentrations. However, during the placebo condition, higher AEA concentrations were correlated with disliking the ‘drug effects’, suggesting a possible relationship between AEA levels and negative expectations of subjective drug effects. Conclusions These findings provide novel insights into how stimulant drugs act on the eCB system and may help to develop treatments for SUDs.

Congrats to @pact-lab.bsky.social PhD student @anadeutsch.bsky.social on her 1st first-author paper from the lab! 🎉

She explored how MDMA & methamphetamine impact cortisol, endocannabinoids, & BDNF levels in healthy humans and how this relates to the subjective drug experience 💊👇

Matt making October easy for us who watch a horror film a day through the month 😏

Jane Goodall, ethologist and conservationist, has died. She was 91

Connectome harmonics: a novel method exploring the psychedelic experience - Neuropsychopharmacology Neuropsychopharmacology - Connectome harmonics: a novel method exploring the psychedelic experience

#ThisWeekInNPP

This ✨ Research Highlight ✨ from @connorhaggarty.bsky.social discusses a recent study (see 👇) showing that intravenous DMT shifts 🧠 dynamics measured by connectome harmonics, with effects that mirror LSD & psilocybin and contrast with unconscious states

Sosa Lab

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.

Incredible week at #EBPS2025. Great location, great science, great food, and great friends. Can’t wait to do it again. Looking forward to our new leadership from @gavanm.bsky.social. Keep your eyes peeled for our new communications initiatives 😉

A Two-Phase, Dose-Ranging, Placebo-Controlled Study of the Safety and Preliminary Test of Acute Effects of Oral Δ8-Tetrahydrocannabivarin in Healthy Participants | Cannabis and Cannabinoid Research Introduction: Tetrahydrocannabivarin (THCV) is an understudied cannabinoid that appears to have effects that vary as a function of dose. No human study has evaluated the safety and nature of effects…

🧠 Study published in Cannabis and Cannabinoid Research suggests THCV may improve sustained attention and is well tolerated in healthy adults.

Promising early evidence for therapeutic uses in attention disorders.
www.liebertpub.com/doi/10.1089/...

Super excited to be elected as a new Full Committee member of @eurbehavpharm.bsky.social happy to be part of the society and looking forward to contribute to it within the next few years! 🤩

What a perfect ending of #EBPS2025 super proud that I was the chair of this wonderful panel presenting their beautiful work on acute and chronic #cannabis effects. Excellent work @connorhaggarty.bsky.social @zivacooper.bsky.social Amir Englund & Lukas Eggeneberger 🤩

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I used incredible twice.. must have been good

Had the immense pleasure of presenting our recent PE+THC clinical trial data today at #EBPS2025. Thanks to @krollsara.bsky.social for the invite. I was in good company with Lukas Eggenberger, @zivacooper.bsky.social and Amir Englund

How to summarize the incredible amount of knowledge @jfcryan.bsky.social has produced in a 45minute talk. Incredible keynote this morning! #EBPS2025

Nice mid thought capture as I consider how Imposter Syndrome has affected me and the skills to combat it

Another great psychedelics panel (I know what I like), chaired by @anadeutsch.bsky.social with presentations by her on data @hannamolla.bsky.social and I collected with Dr de Wit, Dr. Gibson Cook and Dr Helena Aicher #EBPS2025

@sirileknes.bsky.social opening our #ebps2025 session on dense sampling studies in pain and interoception. Come to sala2 to catch it now!

Presidents dinner at #EBPS2025. So great to connect with EC members featuring 5 EBPS presidents

I had the pleasure of attending a psychedelics masterclass this afternoon chaired by Harriet de Wit with talks from Kathryn Cunningham, Chuck Nichols, @drfriid.bsky.social & @mayoonthebrain.bsky.social. From molecules to behaviour and practical steps in trial design #EBPS2025

Registration booth is open! Get there early to avoid lines and get your awesome swag! ##EBPS2025 @eurbehavpharm.bsky.social

Anyone else EXCITED about #EBPS2025? 🎉
Safe travels to everyone coming from around the globe to gather with us in Almeria! 🌎✈️
We still have work to do, but I am proud of our geographic representation at this small meeting.
Thank you @connorhaggarty.bsky.social and Margarita Moreno for the image!

Don't miss this new ✨ Research Highlight ✨ from
@connorhaggarty.bsky.social 🤩

And be sure check out the original @npp-journal.bsky.social paper, exploring effects of DMT on connectome harmonics, subjective experience, & comparative psychedelic experiences www.nature.com/articles/s41...

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences - Neuropsychopharmacology Neuropsychopharmacology - N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

The original article can be found here www.nature.com/articles/s41...

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I wrote a Research Highlight for @npp-journal.bsky.social - based on the recent work of Jakub Vohryzek - describing Connectome Harmonics and how they can help us to understand the psychedelic experience. #Psychedelics #Consciousness #Connectome Read it here www.nature.com/articles/s41...

Thanks to @drjkhokhar.bsky.social & Cece Hillard for another fantastic Cannabinoid GRC!

The #cannabinerd crew is unparalleled & I couldn't be more excited for the opportunity to organize the 2029 meeting with @ryanmcpickle.bsky.social

Incredible time at the Cannabinoid GRC! @drjkhokhar.bsky.social & Cece Hilliard knocked it out of the park! It was an honor to be discussion lead for the GRS session on therapeutics. As always, proud of my friend/mentor @mayoonthebrain.bsky.social, chosen as 2029 chair w/ @ryanmcpickle.bsky.social

Deconstructing the trip treatment: are hallucinogenic effects critical to the therapeutic benefits of psychedelics? - NPP—Digital Psychiatry and Neuroscience NPP—Digital Psychiatry and Neuroscience - Deconstructing the trip treatment: are hallucinogenic effects critical to the therapeutic benefits of psychedelics?

Are hallucinogenic effects critical to the therapeutic benefits of psychedelics?

🆕 Primer by Dr. Albert Garcia-Romeu @jhpsychedelics.bsky.social breaks down what's known about the role of therapy & subjective effects in driving psychedelics' putative efficacy

www.nature.com/articles/s44...

Congratulations to this year's cohort of travel awardees. The committee had an incredibly hard job with over 100 applications! We look forward to seeing you all in Spain next month. Attendees, the data blitz highlighting the awardee's work is on Day 1 at 15:10. #EBPS2025

I'm very excited to be attending my first GRC this year, and focused on cannabinoids no less! I will be leading the discussion for the symposium exploring current cannabinoid therapies, at 9-11am on Sunday August 17th!
#Cannabinerds