"That's not how you advance civilization"
🧪⚒️🚀🛰️🪐

The damage done - Nature Medicine When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

148 clinical trials have been impacted, with 138k patients due to be enrolled or already enrolled.

Once research stops, some won't pick up where they left off. Even when terminated funding was reinstated, things do not go back to normal.

There is so much waste happening.
🧪 archive.today/Rii7f

Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice | Nature Communications In vitro-transcribed and circularized RNAs (ivcRNAs) represent a robust platform for sustained protein translation, offering promising potential for localized therapeutic delivery in joint diseases. Osteoarthritis (OA), the most prevalent degenerative joint disorder, remains a major clinical challenge due to its progressive nature and the lack of disease-modifying treatments. In this study, we identify Musashi2 (Msi2) deficiency in articular chondrocytes as a key contributor to OA pathogenesis. To evaluate the efficacy of ivcRNA-mediated protein replacement therapy, we developed a localized delivery strategy that enables high-yield and prolonged protein expression in chondrocytes. Using a destabilization of the medial meniscus (DMM) mouse model, we demonstrate that intra-articular delivery of ivcRNA encoding MSI2 effectively mitigates OA progression in male mice. Furthermore, therapeutic supplementation of SOX5, a downstream effector of MSI2, via ivcRNA delivery further validates this

Circular RNA-based therapy using ivcRNAs restores Msi2 in mice, reducing osteoarthritis progression. Promising findings for targeting joint diseases. PMID:41006212, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-63343-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rosie O'Donnell 'terrified' as she says 'insanity is happening in United States'

Rosie O'Donnell said she feels "terrified" about the fact that "insanity is happening in the United States" as she addressed her fans in a lengthy social media video 😮

Majority of Companies Hiking Prices to Cover Tariffs: KPMG

KPMG LLP found many companies are passing costs onto customers while adopting other strategic changes to cope with the duties.

White House memo argues furloughed workers not guaranteed backpay A draft memo from the Office of Management and Budget (OMB) is raising the possibility that furloughed federal workers may not be entitled to backpay from their time off during the government shutd…

White House memo argues furloughed workers not guaranteed backpay

JUST IN: Chicago journalistsa re suing DHS and ICE over force used against reporters:

storage.courtlistener.com/recap/gov.us...

#ReleaseTheEpsteinFiles

Yes, very weird. 🤷🏼‍♂️

Greg Abbott used the Texas National Guard as a propaganda tool here in Texas (the state with an actual border) for a bogus wall and manufactured “invasion.”
Poof! No longer needed.

Note that the only invasions are happening in blue states/cities by our own president against our own citizens.

Civil rights jobs have been cut. Those ex-workers warn of ICE detention violations After layoffs, it's unclear how many people are policing civil rights violations inside the Department of Homeland Security, even as the Trump administration ramps up ICE detention.

After layoffs, it's unclear how many people are policing civil rights violations inside the Department of Homeland Security, even as the Trump administration ramps up ICE detention.

Forbes Daily: Judge Blocks Trump’s National Guard Deployment To Portland Today’s Forbes Daily covers a startup democratizing prenups, pushback on Musk’s payment package, U.S. attacks off Venezuela, the best places to enjoy retirement and more.

Today’s Forbes Daily covers a startup democratizing prenups, pushback on Musk’s payment package, U.S. attacks off Venezuela, the best places to enjoy retirement and more.

Contributor: Do we really want armed 18-year-olds on ICE raids? Many people are expressing interest in joining ICE, which makes recent changes in the agency's hiring and recruiting practices all the more troubling.

Contributor: Do we really want armed 18-year-olds on ICE raids?

When politics crowds the exam room patients suffer • Kentucky Lantern I know what happens when politics crowds the exam room. Administration’s sweeping warnings against pregnant women taking acetaminophen are dangerous.

Commentary by Katie Vandegrift

When politics crowds the exam room patients suffer

"I will not apologize for following my doctor’s advice. I will not accept a politics that makes women choose between untreated pain and public shaming."

kentuckylantern.com/2025/10/06/w...

Ukraine claims strike on 'one of Russia's largest' explosives plants far from the front lines The facility produces a wide range of munitions, including aircraft and artillery shells, guided air bombs, anti-tank missile warheads, and ammunition for air defense and engineering units.

⚡️ Ukraine claims strike on 'one of Russia's largest' explosives plants far from the front lines.

The facility produces a wide range of munitions, including aircraft and artillery shells, guided air bombs, anti-tank missile warheads, and ammunition for air defense and engineering units.

Kremlin Dismisses Merz’s ‘Baseless’ Claim That Russia Is Behind Drone Flights in Germany - The Moscow Times German Chancellor Friedrich Merz’s claim that Russia was behind a series of drone sightings in the skies above Germany last week is “baseless,” the Kremlin said Monday.

Merz had said Germany “assumes that Russia is behind most of these drone flights” after the sightings caused two consecutive closures at Munich Airport last Thursday and Friday.

‘Send Them Off’ The Planet: Jane Goodall Criticized Musk And Trump In Netflix Interview Before Her Death The renowned conservationist’s last major interview, recorded back in March, has received a posthumous release on Netflix.

The renowned conservationist’s last major interview, recorded back in March, has received a posthumous release on Netflix.

Guardsmen lace up their boots | Latest US politics news from The Economist The latest news in US politics, with coverage of Donald Trump’s second term.

♦️ A judge again halts the National Guard’s deployment in Portland, Oregon.

♦️ Neither party seems ready to budge on the shutdown.

♦️ The administration reportedly considers an overhaul to Social Security disability benefits.

Keep up with US politics

Federal judge blocks Trump from deploying Oregon National Guard to Portland This is a breaking news story and will be updated. A federal judge has temporarily blocked President Donald Trump from federalizing and deploying Oregon National Guard troops to Portland following a c...

A federal judge has temporarily blocked President Donald Trump from federalizing and deploying Oregon National Guard troops to Portland following a challenge from the state and the city of Portland.

via @oregoncapitalchronicle.com
www.newsfromthestates.com/article/fede...

Trump administration sending California troops to Oregon after court loss, governors say Hours after a federal judge blocked the Trump administration from mobilizing 200 Oregon National Guard troops in Portland, the federal government began sending California National Guard troops to Oreg...

ICYMI: Hours after a federal judge blocked the Trump administration from mobilizing 200 Oregon National Guard troops in Portland, the federal government began sending California National Guard troops to Oregon.

via @oregoncapitalchronicle.com
www.newsfromthestates.com/article/trum...

Federal judge rebukes Trump administration attempt to deploy Guard units from California, Texas to Oregon In summary In an extraordinary Sunday night hearing, federal District Judge Karin Immergut temporarily blocked the Trump administration from deploying federalized troops from any state to Oregon.

FROM @calmatters.org: In an extraordinary Sunday night hearing, federal District Judge Karin Immergut temporarily blocked the Trump administration from deploying federalized troops from any state to Oregon.

www.newsfromthestates.com/article/fede...

Federal judge bars Trump administration from sending any National Guard troops to Portland Saying the Trump administration directly contravened her Saturday order blocking the federal government from mobilizing National Guard troops in Portland, a federal judge issued a broader order barrin...

A federal judge issued a broader order barring the federal government from relocating National Guard members to Oregon from any state.

via @oregoncapitalchronicle.com
www.newsfromthestates.com/article/fede...

French borrowing costs top Italy’s as Lecornu’s resignation forces risk rethink Paris’s benchmark 10-year borrowing costs have risen above Rome’s, due to concerns about its ability to put public finances back on a solid footing.

France’s benchmark borrowing costs rose above those of Italy today after the shock resignation of Prime Minister Sébastien Lecornu forced financial markets to confront the extent of the country’s political dysfunction.

I understand that is the case in these abductions. They get a bonus for each person they abduct, regardless of their victim’s status.

Resist ✊

🥹

Tank man

✊

This video of Chicagoans intervening to save a man from being abducted off the streets by ICE is making the rounds on Instagram.

Community action works.

Source: www.instagram.com/reel/DPZL2AL...

Federal judge temporarily blocks Trump administration from sending National Guard troops to Oregon A federal judge temporarily blocked the Trump administration from deploying any National Guard units to Oregon, including the California National Guard.

BREAKING: Federal judge temporarily blocks Trump administration from deploying any National Guard troops in Oregon.