Juliane Glaser

We wrote a piece on how easy it is to write gene regulatory sequences. - Turns out, it isn't that easy even though we know a lot about cis-regulation.

huge credit to @carldeboer.bsky.social to seeing this through so our thoughts aren't lost. I promise, it's a worthwhile read!

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🤩💪 Out now! 3D regulatory hubs in sex determination

With @mamartirenom.bsky.social & Capel labs, led by @imotagom.bsky.social & @jrotwitguez.bsky.social

1️⃣ METALoci – explore #3DGenome 🧬
2️⃣ Non-coding region controlling Fgf9 🧩
3️⃣ Meis genes = new key players 🌟

👉 rdcu.be/e5sm2

1/n Bluetorial 👇

We're recruiting a PhD student to try and understand stress memory and gene function, using gene editing, in trees! #plantscience

To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607

During germline epigenetic reprogramming, Polycomb must be restricted in the gametes to ensure proper genome regulation in the fertilized embryo. 2 must-read papers assess what happens when Ezhip (Polycomb antagonist) is lost. They come to highly similar conclusions and should be read in tandem 1/4

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports....
Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

Antisense transcription can induce expression memory via stable promoter repression - Genome Biology Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...

⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...

Would anyone out there be able to share some Mus Spretus DNA with us? 🐀🧬 Any tissue of origin, for PCR amplification of selected genomic regions. Many thanks in advance!

🧬 We’re #Hiring a #Bioinformatician/ Computational Biologist!
#Single-cell genomics, #Epigenomics & #3Dgenome biology in #Zebrafish #DevBio 🐟
📍 @cabd-upo-csic.bsky.social, CABD, Seville (Spain)
🕒 Full-time, 3-year position (start March 2026)
📅 Apply by Feb 15, 2026
👉 drive.google.com/file/d/1M8rp...

#APPLYNOW
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/

Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41...
Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)

🚨Application for the MPI-IE international PhD program is ongoing🚨
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠

We are looking for a Scientist as Application Specialist »Next Generation Sequencing« (m/f/div) to work with cutting-edge tech like AVITI24 & NovaSeq.

Part 2: You will play a key role in advancing the broard portfolio of NGS methods to support ambitious research projects at our institute. Use cutting-edge sample preparation and deep sequencing technology including short- and long-read sequencing systems • AVITI24, NovaSeq6000, Nanopore Sequencing and more • Robotic liquid handling device Biomek i7

We offer A full-time position in a stimulating, international interdisciplinary research environment within the Max Planck Society and much more! Apply by February 2nd, 2026

🧬 Join our Deep Sequencing Facility! 🧬

We are looking for a Scientist as Application Specialist »Next Generation Sequencing« (m/f/div) to work with cutting-edge tech like AVITI24 & NovaSeq.

📍 Freiburg, Germany 🇩🇪
📅 Apply by Feb 2, 2026
🔗 jobs.ie-freiburg.mpg.de/jobposting/d...

Ibrahim Cisse, Nicola Iovino and Asifa Akhtar during the Max Planck Freiburg Christmas Apéro

Ibrahim Cisse, Nicola Iovino and Asifa Akhtar in front of the MPI-IE team during the Max Planck Freiburg Christmas Apéro on Dec. 11.

Ayele Denboba and Juliane Glaser enjoying some mulled wine

Results of our 2025 Christmas wreath competition – using only laboratory materials and equipment to create your lab christmas decoration

🎄🌟 Season’s greetings from the entire team of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg … with a few impressions from our Winter Cookie Fair on December 11. ❄️

We wish you Happy Holidays and best wishes for 2026!

Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...

Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)

Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW

Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17

🚨We are recruiting two PhD students 🚨

1) Quantitative & dynamic analysis of limb-regenerative signaling centers w/ @osvaldo-chara.bsky.social 📶🧮💻
🔗https://www.phd.tuebingen.mpg.de/80704/Quantitative-and-dynamic-analysis-of-limb-regenerative-signaling-center-interactions

Congratulations Agnese and all authors!!!! 🥂

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Retroviral insertions contributed to the divergence of human and chimpanzee brains Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...

New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.

www.biorxiv.org/content/10.6...

Come do your PhD with @stemundi.bsky.social and me to uncover mechanisms of lncRNA function using cutting-edge techniques in vivo! 🧬 Project and application details below 👇

Join us for tomorrow´s 📢 CIBSS Seminar Series

🗓 09 Dec 2025 | 12:00–13:00
👩‍🔬 @julianeg.bsky.social, (@mpi-ie.bsky.social)
🎙 Endogenous retroviruses and mouse developmental malformations
📍 Lecture Hall, Institute of Biology I, Hauptstr. 1

See more: kurzlinks.de/iplv

#CIBSS #Science #Immunobiology

Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model Stem cell–derived mesodermal organoids reveal how signaling centers guide cell fate and tissue organization.

🎉 Our deconstructed, stem-cell–based approach to studying signaling centers and limb-development cell types is out! 🥳 So nice to see it in its final form after the preprint— and huge thanks to the community for all the enthusiasm and interest since then!
www.science.org/doi/10.1126/...

Congratulations Can & team!!! Happy to see it out and looking forward to reading the peer-reviewed version 😊

Project Assistant The Department of Medical and Translational Biology at the Faculty of Medicine is now seeking a project assistant for a research project related to human brain aging. The position is full-time and lim

📣We are looking for a Project Assistant to join my group at the Wallenberg Center for Molecular Medicine at Umeå University. Join us if you are interested in transposable elements, epigenetics and human brain aging. 🧠🧬 Dont hesitate to reach out with any questions! 📣
umu.varbi.com/en/what:job/...

Development's Pathway to Independence Programme Our grants support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conference...

Applications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions:

Mentoring
Profile raising
Leadership training
Network building

Spread the word...

www.biologists.com/grants/devel...

Congratulations Fany!! 🥂