Precon_all is finally citeable! I’m relieved, pleased, thrilled and all other superlatives to present to you our preprint describing the inner workings of the precon_all pipeline for semi-automated non-human cortical surface reconstruction! www.biorxiv.org/content/10.1... 1/10

The Baller Lab is thrilled to announce that @elenaccooper.bsky.social just had her first first-author publication! “Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol” is now published on BMJ Open: bmjopen.bmj.com/content/15/5/e094733! 🧠

We are seeking a scientific coordinator for my research group at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig 😊🧠🌈

Could be ideal for a gap year between MSc and PhD or PhD and postdoc!

Please out more here: recruitingapp-5218.de.umantis.com/Vacancies/43...?

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans - Nature Communications The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a secon...

Hot off the press! We found that electroconvulsive therapy (ECT) induces a previously undescribed, second brain event after seizure, called cortical spreading depolarization (CSD), using optical neuroimaging in both a mouse model to human patients. 🧵 below!

doi.org/10.1038/s414...

Pretty incredible. Love "it's about the journey"!

Excited to share our work “Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition,” now out at @pnas.org www.pnas.org/doi/10.1073/....

Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...

Funded by National Institute of Mental Health (NIMH)

Super convincing results alongside treatment implications where options historically haven't been great. Thread below and in longer format on the other site x.com/PinesAndrew/...

Cortical maturation unfolds hierarchically, endowing the PFC with extended plasticity. But do timeframes of plasticity vary across PFC layers?

With 7T quantitative myelin imaging, EEG, and cognitive data, we uncover heterochronous laminar maturation in the PFC 1/n. www.biorxiv.org/content/10.1...

The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow - Nature Neuroscience The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensory cortex and a core relatively insulated from environmental input, and it uniquely balances its output across sensory hierarchies.

Out in @natureneuro.bsky.social today 🥂

Cytoarchitecture, wiring and signal flow of the human default mode network

Combining 3D histology, 7T MRI, and connectomics to explore DMN structure-function associations

Led by Casey Paquola, @themindwanders.bsky.social & a terrific team of colleagues 🙏

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy The brain is highly structured both at anatomical and functional levels. However, within individual brain areas, neurons often exhibit very diverse and seemingly disorganized responses. A more careful analysis shows that these neurons can sometimes be grouped together into specialized subpopulations (categorical representations). Organization can also be found at the level of the representational geometry in the activity space, typically in the form of low-dimensional structures. It is still unclear how the geometry in the activity space and the structure of the response profiles of individual neurons are related. Here, we systematically analyzed the geometric and selectivity structure of the neural population from 40+ cortical regions in mice performing a decision-making task (IBL public Brainwide Map data set). We used a reduced-rank regression approach to quantify the selectivity profiles of single neurons and multiple measures of dimensionality to characterize the representational geometry of task variables. We then related these measures within single areas to the position of each area in the sensory-cognitive cortical hierarchy. Our findings reveal that only a few regions (in primary sensory areas) are categorical. When multiple brain areas are considered, we observe clustering that reflects the brain’s large-scale organization. The representational geometry of task variables also changed along the cortical hierarchy, with higher dimensionality in cognitive regions. These trends were explained by analytical computations linking the maximum dimensionality of representational geometry to the clustering of selectivity at the single neuron level. Finally, we computed the shattering dimensionality (SD), a measure of the linear separability of neural activity vectors; remarkably, the SD remained near maximal across all regions, suggesting that the observed variability in the selectivity profiles allows neural populations to maintain high computational flexibility. These results provide a new mathematical and empirical perspective on selectivity and representation geometry in the cortical neural code. ### Competing Interest Statement The authors have declared no competing interest.

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
www.biorxiv.org/content/10.1...
#neuiroscience

We're excited to release new versions of our BIDS-Apps for processing and analyzing #dmri data, QSIPrep and QSIRecon! Our team has been working hard to prepare these pipelines to process infant data and bring them in line with the @nipreps.bsky.social ecosystem. #neuroimaging #nipreps #bids 1/10

Super excited to share our official ACORN Lab website!! 🍁🧠

appliedcognitionlab.psychology.uconn.edu

We are recruiting new team members at the undergraduate, graduate, and postdoctoral levels - join us!

#Neuroskyence #neuroimaging #PsychSciSky #CogPsyc #ClinPsych #CogDev #devpsy #CogSci

Spiraling waves are everywhere in cortex. They mirror each other across long distances and hemispheres. And they are coordinated with subcortical spiking.
The brain is telling us how it works. biorxiv.org/content/10.1...

SO proud of my outstanding mentee Alisha Shetty for her FIRST FIRST AUTHOR article in the JNeuro Journal Club! Alisha wrote such a thoughtful commentary on current work in this field, reflecting her impressive breadth and depth of knowledge and scientific thinking! www.jneurosci.org/content/43/4...

🎇Join Our Team 🎇 Ted Satterthwaite and I are recruiting a new post-doc or senior scientist to lead a series of meta-analyses focused on clinical trials of PSYCHEDELICS. Expertise in meta-analyses, clinical trials, or psychiatry ideal. Flexible start date/compensation. Please share / DM me!