Amanda Ali

Monthly #OARSI ECI Publication:
@amandality.bsky.social and her team identified miR-126-3p as a promising biomarker for knee #OA. It reduces angiogenesis and mitigates disease severity, supporting its potential as a therapeutic target.

Looking forward to your updates!

Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics This review provides an overview of the work performed in the realms of genetics, genomics and epigenetics in osteoarthritis (OA) research over the past year.

🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social!

www.oarsijournal.com/article/S106...

Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!

Truly an honor to be invited by #OARSI and @oacjournal.bsky.social to summarize all the amazing work in the genetics, genomics, and epigenetics of #osteoarthritis over the last year. A tough job with many great papers not included, but our review is now online: www.oarsijournal.com/article/S106...

All the right pieces in all the wrong places (also how I write grants).

Wordle 1,530 2/6

🟨🟨🟨🟨🟨
🟩🟩🟩🟩🟩

Kudos to Postdoc Madhu Baghel who led this project applying a custom sequencing analysis pipeline that included discovery of novel microRNAs in early-stage osteoarthritis and rheumatoid arthritis, laying a foundation for future biomarker studies. Read our paper here: www.nature.com/articles/s41...

More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.

Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis Scientific Reports - Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis

🚨🚨New publication alert! The Ali Lab @amandality.bsky.social ‬ in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports ‪@natureportfolio.nature.com‬, read it here: rdcu.be/eylic

The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage

My gratitude to the Beier family for allowing us to join his celebration of life memorial. Frank will be deeply missed by the scientific community and will not be forgotten. I am so grateful for his mentorship in shaping my career in osteoarthritis research. We love you Frank. @beierlab.bsky.social

In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers

Thank you, @beierlab.bsky.social , for your remarkable impact you will be deeply missed

❤️ The Frank Beier Graduate Opportunity Scholarship is one way your legacy of generosity and mentorship will live on. I miss you!

www.giving.westernu.ca/giving/frank...

Nothing. Nothing. Something.

Wordle 1,492 3/6

⬛⬛⬛⬛⬛
⬛⬛⬛⬛⬛
🟩🟩🟩🟩🟩

Synovial fluid as a complex molecular pool contributing to knee osteoarthritis Nature Reviews Rheumatology, Published online: 07 July 2025; doi:10.1038/s41584-025-01271-4The synovial fluid lubricates joints while also collecting molecular mediators from surrounding tissues. This Review highlights how molecular analyses of the synovial fluid might provide information on the progression of knee osteoarthritis and treatment efficacy, and identify potential therapeutic strategies targeting synovial fluid mediators in knee osteoarthritis.

ICYMI: New content online:

Appreciate the feature of our recent publication in @natcomms.nature.com, thank you @henryfordhealth.bsky.social Ortho in Motion! www.henryford.com/-/media/file...

Scientists - Arthritis National Research Foundation | Funding Research To Cure Arthritis Education & Resources Scientists We invite you to meet the talented and dedicated scientists who are at the forefront of arthritis research. Each year, our esteemed Scientific Advisory Board carefully...

Congrats to the newest cohort of Arthritis National Research Foundation (ANRF) awardees! This is a fantastic career development opportunity as ANRF provides support for its funded scientists in so many ways. Happy to be alum. curearthritis.org/arthritis-re...

New hospital will be Ontario’s first to serve just women and children A new Mississauga hospital will be Ontario’s first to focus on prenatal and postnatal care, childhood and adolescence, and the health needs of women throughout their lives.

A new hospital in Mississauga will be the first in Ontario to serve just women and children. Shah Family Hospital will focus on prenatal and postnatal care, childhood and adolescence, as well as the health needs of women, by Kristin Rushowy www.thestar.com/politics/pro... via @thestar.com

Jonathan Braman, MD (Chair, Orthopaedic Surgery at Henry Ford Health) delivers opening remarks at the Henry Ford + Michigan State University Musculoskeletal Research Retreat held in East Lansing, MI on 06/17/2025.

Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!

Yesterday was a great day for musculoskeletal researchers and clinicians from Henry Ford and MSU attending the inaugural partnership event aimed at bridging gaps and fostering collaboration to advance translational research. Happy to have co-chaired this retreat with @mattharkeyphd.bsky.social.

Figure showing cumulative prevalence of major musculoskeletal diseases in the USA by age group (2021).Copyright: The Author(s). Published by Elsevier Ltd. CC BY-NC-ND 4.0 license.

Musculoskeletal diseases have risen sharply with global ageing, affecting over 121 million people in the USA.

In ‪The Lancet Healthy Longevity, authors discuss the need for personalised, multidisciplinary approaches to address these diseases: tinyurl.com/4ybej569

Thank you for having us! It was great to finally meet you in person. Was my first time at U of M. Already looking forward to the meeting next year.

Excellent presentation by Research Associate Thomas Wilson from the Ali Lab @hfhs-bjc.bsky.social at the 9th annual Musculoskeletal Health Symposium @uofmichigan.bsky.social! Grateful for the opportunity to share our research on the podium and to connect with fantastic MSK Twitter colleagues IRL.

From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying the...

New publication alert! A summary of the research discussed at the 3rd Workshop on the Epigenetics of OA held in Toronto last September. From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis - Osteoarthritis and Cartilage Open www.oarsiopenjournal.com/article/S266...

A privilege having Dr. Joakim Lundeberg (pioneer of spatial omics) as our keynote speaker for the @henryfordhealth.bsky.social 22nd Annual Research Symposium last week and a pleasure for the Ali lab to join him for dinner on Friday at La Lanterna in Detroit!

More alternatives to knee replacement surgery are emerging Many people aren’t eligible for knee replacement surgery because of health issues.

More alternatives to knee replacement surgery are emerging. Physicians caution that the treatment aren’t permanent fixes, but they may work well for some, especially those not eligible for surgery, by Rebecca Theim www.washingtonpost.com/health/2025/... via @washingtonpost.com

Today: Co-chairing for my 3rd and final year the 22nd annual HFH @henryfordhealth.bsky.social Research Symposium!

From mechanism to medicine: the progress and potential of epigenetics in osteoarthritis Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally…

For the 3rd #EpigeneticsOA workshop, 77 attendees united to discuss progress and potential of our field. Delighted to see the meeting report in print! Whether you made it, or missed out, catch up w/ the outcomes here --> bit.ly/42YeWnT #orthosky @oacjournal.bsky.social @versusarthritis.bsky.social

Congratulations to paper of the year winners! #OARSI2025

Getting real-time updates certainly helps offset the FOMO from not being able to attend OARSI this year! Congratulations to our team on the Basic Science Publication of the Year award from @oacjournal.bsky.social!