The Lancet Rheumatology

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ICYMI

NEW REVIEW—Synovial immunopathology in psoriatic arthritis: cellular and molecular insights bit.ly/4pKi9Su #Medsky #Rheumsky

Can AI be used to classify the focus score in Sjögren's disease?

Linked Comment by Tamandeep K Bharaj & Kathrine Skarstein
bit.ly/48dXWyl

Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study This study showed that deep learning can reliably classify the focus score and Sjögren's disease using minor salivary gland biopsy exclusively. The study identified that CD8+ T-cell infiltration in ac...

NEW RESEARCH—Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study bit.ly/3W2mXVX #Medsky #Rheumsky

NEW podcast episode🎧

Deputy Editor, Sophie Woolven, talks to @ScottUhlrich about personalised gait retraining for knee #osteoarthritis

Apple: bit.ly/3VBBXcZ
Spotify: bit.ly/47W9TbI

Full Article: bit.ly/4nk2rfd
#Medsky #Rheumsky #Biomechsky

Join our Lancet Webinar on the importance of analysing, reporting, and interpreting data according to sex and gender. Copyright: Elsevier Ltd.

Join Zoë Mullan and other Lancet Group editors to learn more about the SAGER guidelines for sex- and gender-based analyses, explore real research examples, and gain practical tips for responding to the guidelines.

📅 21 October, 2pm BST
👉 Register: hubs.li/Q03FQ_6l0

Our October issue is live!

Including research on #vaccination in #rheumatoidarthritis and
#hydroxychloroquine during #pregnancy, two Reviews on #VEXAS, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

NEW RESEARCH—The global, regional, and national burden attributable to low bone mineral density, 1990–2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021 bit.ly/4mhrbDx #Medsky #Rheumsky #GBDStudy @ihmeuw.bsky.social

NEW—Unscientific vaccine policy endangers vulnerable patients

Read our latest editorial bit.ly/3HWybYD #Medsky #Rheumsky

Cover of The Lancet Obstetrics, Gynaecology, & Women's Health. The illustration shows a woman and the outline of a woman: the woman holds a stethoscope to the woman's outline. Within the outline are 6 images of women in different stages of their life.

Our inaugural issue is out now! 🎉

Explore and download our first issue and read featured content, Editor's picks, announcements, and much more on our journal homepage: hubs.li/Q03GFPRK0

Thank you to our authors and reviewers!

#medsky #physician-researcher #obgynsky #womenshealthsky

Modelling allopurinol-induced severe adverse cutaneous reactions

Linked Comment by @profbeckyg.bsky.social & Lisa K Stamp bit.ly/47JPK8N

NEW RESEARCH—Development and validation of a prognostic model for predicting the risk of allopurinol-induced severe cutaneous adverse reactions: a retrospective new-user cohort study using linked primary care, hospitalisation, and mortality data bit.ly/4mc76P1 #Medsky #Rheumsky

NEW COMMENT—Targeting B-cell activation to tackle both patient-reported and systemic disease outcomes in Sjögren's disease bit.ly/46xopoY #Medsky #Rheumsky

Biomarkers for juvenile idiopathic arthritis treatment response—have we identified them?

Linked Comment by Stephanie KA Wong & Marinka Twilt bit.ly/42o1j1D

NEW RESEARCH—Serum biomarkers associated with baricitinib response in patients with juvenile idiopathic arthritis: a post-hoc analysis of the phase 3 JUVE-BASIS trial bit.ly/4nrPIqK #JIA #Medsky #Rheumsky

Mapping the infectious burden in VEXAS syndrome: a systematic review and rationale for prevention

Valentine Ribier and colleagues characterise the infectious burden of VEXAS syndrome and propose preventive strategies bit.ly/3VDJIPq
@terrierben.bsky.social
@sophiegeorgin.bsky.social

VEXAS syndrome and immune-mediated rheumatic diseases: overlaps in clinical features and mechanisms

Arvind Kaul and colleagues explores the links between VEXAS syndrome and rheumatic diseases, offering guidance on current management strategies bit.ly/4nkqhY4
@helenlachmann.bsky.social ‬

NEW—Two Reviews on VEXAS syndrome, a disorder caused by an acquired monogenic somatic UBA1 gene mutation which affects ubiquitination and triggers immune dysregulation, leading to diverse clinical and pathological features resembling inflammatory rheumatic diseases
#Medsky #Rheumsky #Heamsky

Challenges in the therapeutic management of psoriatic arthritis

Linked Comment by Dafna D Gladman @uoftrheum.bsky.social bit.ly/462VKqp #Rheumsky #Medsky

NEW RESEARCH—Effect of a treatment strategy utilising golimumab, methotrexate and corticosteroids vs methotrexate and corticosteroids in early, untreated #psoriaticarthritis bit.ly/465KoSC
@drailyntan.bsky.social @universityofleeds.bsky.social @nihrleedsbrc.bsky.social #Rheumsky #Medsky

NEW Correspondence—Further progression in patients with systemic sclerosis-associated interstitial lung disease

Letter ➡️https://bit.ly/45KZm1v
Authors' reply ➡️https://bit.ly/3JKrfhy
Linked to this Article ➡️https://bit.ly/4gbwFi0
#Medsky #Rheumsky

📢Calling all aspiring rheumatologists in Sub-Saharan Africa!

#EULAR and #AFLAR are enhancing #rheumatology training in Sub-Saharan Africa with free access to high quality online courses.

Register here: https://pulse.ly/7n75afapml

📅Deadline: 15 September 2025.

#MedicalEducation

Aspirin desensitisation in pregnant individuals with autoimmune disease In pregnancy, low-dose aspirin (75–150 mg daily) is recommended for individuals with autoimmune disease as prophylaxis against pre-eclampsia. Meta-analyses show increased pre-eclampsia risk in pregnan...

NEW Correspondence—Aspirin desensitisation in pregnant individuals with autoimmune disease bit.ly/3Vq74rN #Medsky #Rheumsky

From whole-brain metrics to circuit-specific precision: advancing fMRI biomarkers for TNF inhibitor response in rheumatoid arthritis The landmark study by Hess and colleagues1 represents a paradigm shift in rheumatoid arthritis therapeutics by positioning the CNS as a key predictor of TNF inhibitor response. The authors' randomised...

NEW Correspondence—From whole-brain metrics to circuit-specific precision: advancing fMRI biomarkers for TNF inhibitor response in rheumatoid arthritis

Letter ➡️ bit.ly/4lWADw7
Authors' reply➡️ bit.ly/428azXB
Linked to this Article ➡️ bit.ly/4lSNkIf
#Medsky #Rheumsky

In our Sept editorial we discuss the complexities of ILD in rheumatic diseases
bit.ly/4mR9wmR #Medsky #Rheumsky

Our September issue is live!

Including research on #lowbackpain, dual JAK and ROCK inhibition in #rheumatoidarthritis, tapering of TNF inhibitors in #psoriaticarthritis & axial #spondyloarthritis, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

NEW Correspondence—Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with refractory systemic lupus erythematosus

Letter ➡️ bit.ly/3JABcOr
Authors' reply ➡️ bit.ly/45kBsd5

Linked to this Article ➡️ bit.ly/3HD17o9

NEW RESEARCH—Personalised gait retraining for medial compartment knee #osteoarthritis: a randomised controlled trial bit.ly/4luS5aO @utah.edu #ASB2025 #Medsky #Rheumsky #BiomechSky

NEW Essay—Expanding the rheumatology lens: should we embrace POTS and post-infectious syndromes? bit.ly/3J82c7R #Medsky #Rheumsky