Dr Martina Bocchetta

Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study Soskic et al. investigated the involvement of thalamic subregions in genetic frontotemporal dementia using structural and diffusion MRI data. The authors f

New study on the thalamic involvement in genetic #FTD, using an automated tool that combines structural and diffusion 🧠 MRI

doi.org/10.1093/brai...

25.10.2025 07:03 — 👍 1    🔁 2    💬 0    📌 0

Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant - Journal of Neurology Introduction Frontotemporal lobar degeneration (FTLD) includes heterogenous diseases: behavioural variant frontotemporal dementia (bvFTD), primary progressive aphasias (PPA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We applied neuroanatomical normative modelling to quantify individual atrophy patterns and heterogeneity within and between FTLD forms. Methods We included 160 participants across FTLDNI and 4RTNI studies: controls (n = 15), bvFTD (n = 22), nfvPPA (n = 14), svPPA (n = 21), CBS (n = 43) and PSP (n = 45). Using cortical thickness and subcortical volumes from 3T MRIs, we applied normative modelling with a large healthy reference dataset (n = 58,836), further accounting for age, sex, and scanner. Outlier regions (z < – 1.96) were used to compute total outlier counts (tOC) and Hamming distances, capturing individual atrophy patterns and inter-subject dissimilarity. Results bvFTD, svPPA, CBS and PSP showed significantly higher cortical tOC than controls, with all groups showing higher subcortical tOC than controls, especially svPPA and PSP. bvFTD, svPPA, CBS and PSP had significantly higher cortical Hamming distance scores than controls, with higher scores in bvFTD and svPPA than nfvPPA and PSP. svPPA and PSP had significantly higher subcortical scores than controls and CBS. Greater disease severity (measured using the Clinical Dementia Rating—CDR for PSP and CBS, and the CDR® plus NACC-FTLD global scores for FTD variants) was associated with increased tOC and dissimilarity, highlighting the link between clinical progression and neuroanatomical heterogeneity. Conclusions The pronounced heterogeneity within and between FTLD subtypes (particularly in bvFTD) increases with disease progression and may reflect distinct underlying pathologies. This supports the development of subtype-specific biomarkers and emphasize the need for personalized diagnostic and therapeutic strategies.

Normative neuroanatomical modelling to quantify individual 🧠atrophy patterns in #FTLD - results from this UCL and Brunel collaboration are now out: link.springer.com/article/10.1...

24.09.2025 08:16 — 👍 5    🔁 2    💬 0    📌 0

🗓️ Mark your calendars!
Join Prof @selinawray.bsky.social and Dr Ross Paterson for a Reddit ‘ask me anything’ (AMA) on 18 September.
You’ll have the chance to ask our experts questions about dementia research and care as part of #WorldAlzheimersMonth.
Find out more: buff.ly/Y36GExF

03.09.2025 10:08 — 👍 13    🔁 5    💬 0    📌 1

🚨 We’re hiring: Associate Professor/Professor of Cognitive Neuroscience

🧠 Lead pioneering imaging-informed cognitive neuroscience research
🌍 Open to international applicants | Visa sponsorship available
📍 Permanent, full-time, on-site
🔗 Apply now: www.ucl.ac.uk/work-at-ucl/...

11.08.2025 15:53 — 👍 34    🔁 41    💬 1    📌 1

Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth

17.01.2025 15:31 — 👍 24    🔁 10    💬 1    📌 0

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Exciting new job opportunity at the IoN, UCL, London. The post is based at the Department of Imaging Neuroscience. It is a 70-30%research to teaching split. If anyone requires more information on the teaching part then please do get in contact with me. Please repost
www.ucl.ac.uk/work-at-ucl/...

28.11.2024 12:07 — 👍 26    🔁 27    💬 1    📌 0

Picture of textbook cover with title "Introduction to Behavioral Neuroscience"

Announcing a new open access textbook for entry level behavioral neuro. Funded by NSF. Written by a collection of 26 neuro experts. Method demonstration videos and author interviews too. Consider using it in your courses to reduce financial barriers to education.

openstax.org/details/book...

15.11.2024 10:56 — 👍 253    🔁 110    💬 20    📌 17

A (sub)field guide to quality control in hippocampal subfield segmentation on high‐resolution T2‐weighted MRI Illustration of the quality control (QC) process and investigator-guided decision making for data quality. Green checkmarks indicate passed QC, while red cross marks indicate failed QC.

ICYMI: Do you want to perform QC your hippocampal segmentations but don't know how to start? Look no further than this great new paper led by Kelsey Canada & Negar Mazloum-Farzaghi which offers practical QC guidance from the Hippocampal Subfield Group.

onlinelibrary.wiley.com/doi/10.1002/...

13.11.2024 02:27 — 👍 12    🔁 5    💬 0    📌 0

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A next-generation, histological atlas of the human brain and its application to automated brain MRI segmentation | bioRxiv www.biorxiv.org/content/10.1...

07.02.2024 00:49 — 👍 5    🔁 2    💬 0    📌 0