Sofia Ahola

Really interesting results!
Makes you wonder if this could link the role of mitochondria in ageing as well via mtDNA release and cGAS.

It was great working with you and contribute this small part in your project! Will be a colorful reminder of cool science on your wall! 🖼️🧫🧪🖌️😀

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication Tong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R. Thes...

Cell Metabolism www.cell.com/cell-metabol...

Lovely news for the summer! My latest artwork was just published on the cover of @cp-cellmetabolism.bsky.social. Incredible science from @daveyboyhod.bsky.social lab! They discovered how pancreatic alpha cells regulate beta cell function via enriched GLP-1 receptor nanodomains.

Highland Wink of Arthur's Seat (BIMDG Meeting in Edinburgh) to the Finnish Seaside Juhannus!
From whispering winds of the city below, to the shimmering shores of the Finnish midsummer night, where the sun refuses to set! ⛰️🔥😄
Happy Midsummer everyone!

This time science inspired collage workshop that @jonwolfmueller.bsky.social conceptualized for the students @unibirmingham.bsky.social

I was also very proud to swim in that lake that was frozen just a week before! :D

First time as a lecturer in Mitochondrial Summer School! It’s been a while since I got to enjoy the talks as a student. Had fantastic time meeting friends, making new ones and discussing everything mitochondria. Thank you @unioulu.bsky.social and FibroHealth for the lovely time at Rokua, Finland!

De novo serine biosynthesis is protective in mitochondrial disease Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle disease, delaying disease progression. Blocking local biosynthesis of serine challenges cellular phospholipid ho...

Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...

I can come up with one reason at least 😀

I had the chance to host an art workshop for our postgraduate students at MSS @unibirmingham.bsky.social with @jonwolfmueller.bsky.social
It was a great opportunity to combine science and art and enjoy some time together. 🎨 🧪 🧫 🧠
Thanks to everyone who joined — it was an inspiring and fun evening!

Was lovely to meet you all there!

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social

🗞️ doi.org/10.1038/s443...

Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...

Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...

Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....

Mitochondria Summer School

Application deadline approaching fast! If you are a PhD student or a postdoc register for this summer school in the happiest country in the world. Amazing program, amazing people, amazing place! ssl.eventilla.com/mitochondria...

What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬

Great to see this out! Such a beautiful paper! 🥂

📌UK Funding Opportunities After Brexit: Experiences and Practical Guidance
🎙️Sofia Ahola, Vitória Baptista, Selin Tüzüner
🗓️13.3. 7:00 PM CET
🔗https://us06web.zoom.us/webinar/register/WN_6EmZmK8kSSaueDtQWhLz9A
➡ Network: network.febs.org/posts/febs-j...

#YoungFEBS #onlinetalk #funding #career

🌍Euromit 2026 is coming to Angers!🌍

✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨

📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬

Today is #RareDiseaseDay

Did you know there's still no cure for #mitochondrialdisease?

@lilyfoundation.bsky.social are fighting to change this. We've invested over £3 million in research since 2007

Please help us to raise awareness of mito

Find out more
www.thelilyfoundation.org.uk

Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases

Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected

Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...

Mitochondria Summer School in Rokua Join us for an immersive week at the Mitochondria Summer School 2025, where leading experts and researchers will explore cutting-edge topics in mitochondrial biology!

Nature, Science, Sauna, Mitochondria. Great line up of speakers! 😀
💚 Mitochondria Summer School in Finland May2025! 💚

www.oulu.fi/en/events/mi...

I think the co-essentiality of Parkin and Oma1 is indeed the most stricking finding and that it is indeed via fusion. How is the mtDNA maintenance actually regulated in these conditions is still a mystery to me

For example liver looks very different. Perhaps there is a tissue-specific differences in fusion rates

We tried Parkin KD in our MEFs and could boost the mtDNA levels up a little bit. So there is definitely a link there 😅

"The author would like to thank the reviewer for the helpful comments...however, for the focus of this manuscript.." 😀

I hope you inserted some mutations there to "keep the seminar secure" 😉

Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy Inhibition of Opa1 processing in mice allows normal development but exacerbates mitochondrial cardiomyopathy.

Would our Opa1d4 (long-Opa1) mice crossed with Parkin-/- have a similar phenotype with hyperfusion? Opa1d4 affects mtDNA maintenance without innate immune response www.science.org/doi/10.1126/...