Alberto Docampo Seara

Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells

Guest Editors: Alex Hughes and Rashmi Priya

📅 Deadline: 1 March 2026

journals.biologists.com/dev/pages/ex...

#DevBio

🥳 Congratulations to our postdoc, Dr. Anna Czarkwiani @aniaczark.bsky.social, on receiving the ERC Starting Grant @erc.europa.eu!

With €2 million in funding, Anna will explore the biology of gravisensation and uncover insights into related disorders. 🧠

#CMCBnews @tudresden.bsky.social #ERCStG

🧠🧪Funded PhD job offer ok neddylation in glial cells @achucarro.bsky.social

Pls repost

🧠🦈Excited to present our latest work🧠🦈Interested in brain evolution? And shark embryos? Then read on… Our work sheds light on the deep origins of our brain’s most complex regions.

This is just a small piece of a big Timelapse made by a very talented PhD student in the @beckergroup.bsky.social . Credit: @ozuozge.bsky.social . Hopefully something will come soon thanks to it.

Zebrafish larvae are really good for time lapses. Just take some popcorns enjoy them like if they were movies. Here you can see with your own eyes how immune cells divide. This one I call it "Divide and flee" #spinalcordregeneration #zebrafish #timelapse #microglia

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

🚨Anyone want a job?🚨
We have two #postdocs up for grabs! 🧪
- cell developmental biology/#evodevo/#neuroevodevo
- bioinformatics and molecular biology
Both working on brain evolution in Heliconiini butterflies
Details below! Please repost 🙏 1/n

One long standing question answered ✅
Beautiful science ✅
Cool model organism ✅
Congratulations to the authors!

Useful tips from @scekker.bsky.social et al. 🐟

Progenitor heterogeneity in the developing telencephalon. A multi-panelled figure showing different progenitor cells in different areas of the developing telencephalon of the killifish. HCR-FISH targeting CX43 (pan Astro-RG, magenta) and ZIC2 (NE-RG, yellow) (A) or NGPmix (turquoise) (B), is combined with immunohistochemical staining for the proliferation marker PCNA (white). NGPs account for the bulk of proliferation; Astro-RGs and NE-RGs appear both dividing and non-dividing depending on the location in the telencephalon. (C-E) Magnifications of the regions in the boxes in A and B. Non-dividing Astro-RGs (CX43+, PCNA−) are indicated with a magenta arrowhead and appear isolated in between stretches of dividing NGPs. (F) Illustration of a 5 dph coronal telencephalic section at mid-anterior-posterior level. The distribution of dividing and non-dividing Astro-RGs, NE-RGs and NGPs is displayed in the ventricular zone.

African turquoise killifish are short-lived & their CNS exhibits human-like ageing. Zandecki @eveseuntjens.bsky.social & co reveal the cellular diversity during the explosive growth of the telencephalon, uncovering specific progenitor signatures for each neurogenic region. 🧠 doi.org/10.1242/bio....

CellTalk HHD | Human Heart Development Research CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.

🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)

Cardiac regeneration: Unraveling the complex network of intercellular crosstalk The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardi…

Are you interested in how cells talk to each other to promote regeneration in the heart?

@bailinwu.bsky.social @florian-constanty.bsky.social and I are and we wrote a review about it ❤️🐟🐭

Check it out here 👇

www.sciencedirect.com/science/arti...

Regenerating Retinal Neurons using AAV Vectors / ISCRM .

Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social

shorturl.at/qVUKz

This afternoon 👇🏻

Now you can also read all about @idoiaeu.bsky.social beautiful work on catshark brain development and the enigmatic origin of cajal retzius cells in their preprint www.biorxiv.org/content/10.1...

Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish A balanced immune response after cardiac injury is crucial to successful heart regeneration, but knowledge of what distinguishes a regenerative from a scarring response is still limited. The Mexican c...

Excited to share our preprint! We show that sustained macrophage and B cell responses are essential for heart regeneration in Mexican cavefish, helping uncover why surface fish heal but cavefish scar 🫀🐟. Check out the full story:
www.biorxiv.org/content/10.1...

The next 13th of May I’ll be taking about microglia in spinal cord regeneration. If you’re interested 👇🏻👇🏻

Exacerbated sonic hedgehog signalling promotes a transition from chemical pre-patterning of chicken reticulate scales to mechanical skin folding: royalsocietypublishing.org/doi/10.1098/... @lanevol.bsky.social‬ @rorylcooper.bsky.social‬ #OpenBiology #DevBio #biophysics

Congratulations Arica! Great paper. Congrats also to all authors.

Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration Nature Communications - Adult zebrafish are capable of heart regeneration, but how the collagenous injury site is replaced remains unclear. Here they provide an in-depth analysis of cardiomyocyte...

Very excited to see the first Beisaw lab publication out in its final form 🥳🥳 rdcu.be/ei1I7 if you’re interested in zebrafish heart regeneration and how cardiomyocytes replace the fibrotic injured tissue (spoiler alert: macrophages play an important role), then read it here 👇

Mechanical control of tissue growth during limb regeneration The axolotl is a highly regenerative species, capable of restoring full limbs, regardless of the amputation site. However, the regeneration rate is adjusted with the plane of amputation along the prox...

It has been known for a long time that if the starting point of limb regeneration is at the hand level or close to the shoulder, it would take about the same time to regenerate. Puzzling right?
Check out this preprint from our lab to know more about it:
www.biorxiv.org/content/10.1...

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

I am so excited to share our review on microglial heterogeneity @natureneuro.bsky.social! It was a fantastic effort by the lab, led by @c9laura72.bsky.social and Alma Mohebiany. We provide a critical view on the plethora of microglial cell states in health and disease. www.nature.com/articles/s41...

Please register for this amazing meeting! Applications for this meeting must be submitted by June 8, 2025

Left: Expression of Notch3 (white) detected by whole mount RNAscope ISH in an E8.5d wild-type embryo, shown in frontal views (top, cranial part of the embryo) and transverse section (bottom). Filled and empty arrowheads point to high and low expression, respectively. Right: Segmentation of the cardiac region in 3D images, to quantify gene expression in the left (white) or right (yellow) heart field. The heart tube is colored in red. Somites are outlined by white dotted lines. Expression of Notch3 within the segmented second heart field is extracted in the right panel.

Creating an asymmetric heart: @tbonnely.bsky.social @audreydsg.bsky.social @meilhacsigolene.bsky.social &co identify Notch3 as a novel asymmetric factor in lateral plate mesoderm that acts as a genetic modifier of NODAL to regulate heart morphogenesis @plosbiology.org 🧪 plos.io/42q6H4L

In vivo sonic hedgehog pathway antagonism temporarily results in ancestral proto-feather-like structures in the chicken The Sonic Hedgehog (Shh) pathway is a key regulator of feather development. These authors show that in vivo Shh inhibition during early chicken embryogenesis temporarily results in unbranched and non-...

🚨🐣 Our new paper is out @plosbiology.org! Sonic hedgehog inhibition transforms feathers into ancestral protofeathers-like structures. These units then recover after hatching, highlighting their remarkable developmental robustness! @lanevol.bsky.social 🧪

journals.plos.org/plosbiology/...

Le Dréau, G., & Martí, E. (2012). Dorsal–ventral patterning of the neural tube: A tale of three signals. Developmental Neurobiology, 72(12), 1471–1481. #EpithelialMechanicsReview
buff.ly/9LymPIE

🚨 Heads-up: a little over a week to apply for this exciting postdoc opportunity in Edinburgh @edinuni-irr.bsky.social! 🚨

I will be in Liverpool for #biologists100. Happy to chat about the position, our research, setting up a lab, spiny mice, axolotls, and whatnot!