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Anthony Vecchiarelli

@cellforganized.bsky.social

How do bacteria organize their innards? Associate Prof at UMich

809 Followers  |  435 Following  |  110 Posts  |  Joined: 25.10.2023
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Posts by Anthony Vecchiarelli (@cellforganized.bsky.social)

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Radiohead is demanding that the Trump administration take down a pro-ICE promotional video featuring a version of its song β€œLet Down” without permission.

Full statement from the band:

27.02.2026 19:23 β€” πŸ‘ 6263    πŸ” 1562    πŸ’¬ 72    πŸ“Œ 141
Don't be fooled by imidazole! It absorbs UV280, just like protein – on chromatogram it'll be seen!
YouTube video by the bumbling biochemist Don't be fooled by imidazole! It absorbs UV280, just like protein – on chromatogram it'll be seen!

Don't be fooled by imidazole! It absorbs UV280, just like protein – on chromatogram it'll be seen! Imidazole is great for purifying His-tagged proteins, but it's a pain for when you want to detect and measure concentration of proteins using UV280 absorbance! youtu.be/JZeTMXfOtGU

25.02.2026 02:53 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Forget the textbook view of a cell as a calm, orderly place. Glowing trackers reveal that it is jam-packed as a crowded nightclub β€” raising questions about how molecules can encounter their partners for the reactions that enable life. www.quantamagazine.org/the-biophysi...

20.02.2026 15:13 β€” πŸ‘ 38    πŸ” 10    πŸ’¬ 0    πŸ“Œ 2
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NOT watching a pedophile spew lies…

24.02.2026 23:10 β€” πŸ‘ 300    πŸ” 81    πŸ’¬ 18    πŸ“Œ 6
tweet from lisa desjardins reporting SOTU might be up to 3 hours long

tweet from lisa desjardins reporting SOTU might be up to 3 hours long

It’s both funny and cosmically correct that the U.S. men’s hockey chodes will have to sit through 2+ hours of rambling from their addled little king while the U.S. Women’s team gets to skip the speech and party with Flavor Flav in Vegas

24.02.2026 21:22 β€” πŸ‘ 10683    πŸ” 1807    πŸ’¬ 361    πŸ“Œ 169

Exciting line up of talks for CauloCon 2026 - includes keynotes from @brunlabcaulo.bsky.social @lamasonlab.bsky.social and @thanbichlerlab.bsky.social! Hear work from Isaac Payne and Trung Nguyen, 2 students in my lab, on Weds and Thurs. 🀩

23.02.2026 17:52 β€” πŸ‘ 10    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Putting a lot of work into a grant that probably won't get funded due to lack of funding in NIH/NSF. So I'm curious scientists: what work were you excited about that didn't get funding?

Non-scientists, this is the work we are missing out on in the US when we don't fully fund NIG/NSF/USDA/etc

20.02.2026 17:31 β€” πŸ‘ 94    πŸ” 30    πŸ’¬ 8    πŸ“Œ 3
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US political vibes these days be like

22.02.2026 23:31 β€” πŸ‘ 21    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

University of Toronto is hiring:
Assistant Professor of Molecular and Cell Biology

#assistantprofessorposition

22.02.2026 12:36 β€” πŸ‘ 10    πŸ” 25    πŸ’¬ 1    πŸ“Œ 0

Correction. Team Canada vs the US goalie and the refs apparently!

22.02.2026 15:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

40 shots to 20. Basically all of team Canada vs the US goalie.

22.02.2026 15:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Canada has tied the men's hockey gold medal game 1-1 πŸ‡¨πŸ‡¦

Cale Makar with a wicked wrist shot from the faceoff dot gets past Connor Hellebuyck.

22.02.2026 14:49 β€” πŸ‘ 156    πŸ” 13    πŸ’¬ 9    πŸ“Œ 3
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Xiaofeng combined 2D live-cell single-particle tracking with 3D simulations to specifically measure the bacterial nucleoid accessibility and viscosity! Our preprint describes how these nucleoid properties respond to cellular processes! Code is available too.
www.biorxiv.org/content/10.6...

20.02.2026 15:31 β€” πŸ‘ 30    πŸ” 14    πŸ’¬ 0    πŸ“Œ 1
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Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)

18.02.2026 20:09 β€” πŸ‘ 468    πŸ” 137    πŸ’¬ 10    πŸ“Œ 19

Thank you for highlighting our paper on how septal PG hydrolysis licenses a second wave of PG transpeptidation during cell separation! www.nature.com/articles/s41.... I will do a thread when the page set version is out.

18.02.2026 18:49 β€” πŸ‘ 20    πŸ” 7    πŸ’¬ 2    πŸ“Œ 1

Historian of medicine here. Yes. Yes, they did.

17.02.2026 17:47 β€” πŸ‘ 14640    πŸ” 3609    πŸ’¬ 52    πŸ“Œ 87

πŸ“’ Save the date! #Biophychrom2027 will take place at Paris-Saclay in July 2027. More details coming soon!

14.02.2026 18:35 β€” πŸ‘ 6    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky url: academic.oup.com/icb/article-...

14.02.2026 08:37 β€” πŸ‘ 17    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Beautiful paper!
Congrats to all authors!

12.02.2026 19:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Great fun working with Manajit Hayer-Hartl and her amazing team at @mpibiochem.bsky.social bringing this work on the beta-carboxyome protein ApN (CcmN) together.

12.02.2026 00:51 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
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Happy birthday to one of my favourite haters, Charles Darwin

12.02.2026 16:31 β€” πŸ‘ 10351    πŸ” 3082    πŸ’¬ 162    πŸ“Œ 419
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Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology andπŸ›‘οΈ Bacterial Immunity. Come do great science with us in the middle of Paris! πŸ‡«πŸ‡·πŸ₯ research.pasteur.fr/en/job/postd...

28.01.2026 11:19 β€” πŸ‘ 74    πŸ” 81    πŸ’¬ 0    πŸ“Œ 2
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Stages of biomolecular condensate formation in pro-Ξ²-carboxysome assembly - Nature Plants Carboxysomes are cyanobacterial CO2-concentrating compartments with a proteinaceous shell. The elucidation of the role of the shell adaptor protein ApN in stepwise Ξ²-carboxysome assembly will aid the ...

Stages of biomolecular condensate formation in pro-Ξ²-carboxysome assembly www.nature.com/articles/s41...

11.02.2026 08:57 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
Bad Bunny's Apple Music Super Bowl Halftime Show
YouTube video by NFL Bad Bunny's Apple Music Super Bowl Halftime Show

Missed Bad Bunny’s halftime show? Want to rewatch? (4x and counting for me). The NFL posted the whole performance on YouTube: on pace for 500k views in the first 30 minutes.

09.02.2026 05:47 β€” πŸ‘ 1828    πŸ” 817    πŸ’¬ 30    πŸ“Œ 57

I think one of the best things about Bad Bunny’s performance is that it was so *specific*. It so clearly had a point of view coming from real lived experience and actual emotion, actual heart, not cynical calculation. Just beautiful.

09.02.2026 01:36 β€” πŸ‘ 1792    πŸ” 199    πŸ’¬ 12    πŸ“Œ 10

perfect.

09.02.2026 01:34 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

This week in preprints: just one, but it's a fascinating look at how enhancers cluster in 3D space at transcriptional condensates.

08.02.2026 22:04 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Sticker number modulates pyrenoid condensate assembly to support algal fitness The valency of intrinsically disordered proteins underpins liquid-liquid phase separation (LLPS), yet how this parameter shapes condensate function and cellular fitness remains poorly understood. Here we exploit the algal pyrenoidβ€”a minimal, two component LLPS systemβ€”to directly link condensate properties to physiological performance. Pyrenoid assembly is driven by a disordered, multivalent Linker protein that binds Rubisco at symmetry-related surface sites, with the number of binding motifs (β€³stickersβ€³) varying across species. Using Chlamydomonas reinhardtii , we systematically tuned sticker number from two to nine and examined effects on Rubisco condensation, pyrenoid architecture and CO2 fixation. Three stickers were sufficient for condensation in vitro, but at least four were required for pyrenoid assembly in vivo. Cryo-electron tomography and single-molecule tracking revealed that increasing sticker number enhances Rubisco packing and mobility, while time-resolved imaging and competition assays demonstrated that sticker number governs the kinetics of pyrenoid formation and determines cellular fitness under fluctuating carbon conditions. Our findings establish sticker number as an evolutionary tuning parameter that balances condensate formation, dynamics, and function, providing a quantitative framework for linking the molecular grammar of phase separation to biological fitness. ### Competing Interest Statement The authors have declared no competing interest. EPSRC, EP/W024063/1

Sticker number modulates pyrenoid condensate assembly to support algal fitness www.biorxiv.org/content/10.6...

30.01.2026 03:34 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Atomic resolution structure of spinach rubisco reveals protons and dynamics www.biorxiv.org/content/10.64898/2025.12.22.696010v1 #cryoEM

24.12.2025 09:42 β€” πŸ‘ 14    πŸ” 7    πŸ’¬ 0    πŸ“Œ 2
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This is Alex Pretti.

25.01.2026 02:24 β€” πŸ‘ 9517    πŸ” 3127    πŸ’¬ 208    πŸ“Œ 204