François Lallemend

Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden

Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...

A spinal circuit for skilled locomotion Toscano et al. identify glutamatergic Pitx2+ V0 ascending neurons (V0g-aNs) that receive input from cerebrospinal fluid (CSF)-contacting neurons and target spinal premotor and motor neurons. Eliminati...

I really like this one 🤓. Work led by Elisa Toscano with invaluable help from many 🙏 @alesantuz.bsky.social, @lowensteined.bsky.social. A spinal circuit for skilled locomotion www.cell.com/current-biol...

Intercellular communication in the brain through a dendritic nanotubular network Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

🤯

www.science.org/doi/10.1126/...

Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship) Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet

👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻

Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms.

🚨 Deadline Oct 1st!! 🚨

Please re-post and help us spread the word far and wide! ✈

ki.varbi.com/en/what:job/...

Immune-neuron circuits let pain jump between organs. Potential new treatment for bladder-gut disorders
doi.org/10.21203/rs....

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch

www.science.org/doi/10.1126/...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

'Here, we detail the biological, environmental and experimental factors that can affect circadian rhythms of mice and provide recommendations for designing and reporting experiments for in vivo metabolic studies.'
www.nature.com/articles/s42...

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

Maternal stress triggers early-life eczema through fetal mast cell programming

Nadine Serhan et al. 🧪

www.nature.com/articles/s41...

Social Touch Suppresses Aggression via Thalamic Mechanisms https://www.biorxiv.org/content/10.1101/2025.08.23.670446v1

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

Now out in @natneuro.nature.com

What happens to the brain’s body map when a body-part is removed?

Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation

www.nature.com/articles/s41593-025-02037-7

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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

Gut bacteria produce proteins that could seve as new drugs for metabolism disorders, including diabetes or obesity
www.nature.com/articles/s41...

Deep neural network analysis is a powerful tool, biological experimentation remains however essential: it reveals principles that AI can't infer on its own, yet.

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social

www.nature.com/articles/s41...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

WOW!!!!!😱😮

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis TMEM9B-AS1, down-regulated in type 2 diabetes, regulates ribosomal biogenesis in muscle by promoting IGF2BP1-MYC mRNA interaction.

A human specific lncRNA important for ribosomal biogenesis in skeletal muscle- reduced in people with type 2 diabetes.Latest from the team! @ilkesen.bsky.social @juleenrzierath.bsky.social Science Advances www.science.org/doi/10.1126/...

Identification of proliferating neural progenitors in the adult human hippocampus Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

AAV gene therapy for autosomal recessive deafness 9: a single-arm trial - Nature Medicine Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 month...

Gene therapy to treat deafness now a success in young adults!
www.nature.com/articles/s41...

Professor of Pharmacology - Uppsala University Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Cholinergic feedback for modality- and context-specific modulation of sensory representations The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...

Our new paper is out in Science.

We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.

Congrats to Bin for the great thesis, and the team!

www.science.org/doi/10.1126/...

A sensory-motor-sensory circuit underlies antinociception ignited by primary motor cortex in mice Wang et al. unravel the fundamental reason why activation of the primary motor cortex produces analgesia in mice from the angle of sensory-motor interaction and elucidate it from a descending M1-LH in...

BOOM! I think this paper fills a big gap in understanding how motor cortex stim works for pain... like so many things, it all seems to boil down to the ventral-lateral periaqueductal grey (vlPAG) www.cell.com/neuron/fullt...

Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...

A read only for the DRG nerd: "Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons". www.nature.com/articles/s42...

Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...

Postdoctoral studies in single-cell and computational biology Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research?  A postdoctoral position is available in the laboratory of Professor Francois

Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

Great to work with @antofala.bsky.social and Silvia Arber on this
@biozentrum.unibas.ch @fmiscience.bsky.social

A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs - Nature Neuroscience Animals need to adapt behavior to balance survival with fulfillment of essential needs. Krauth et al. identify neurons in the lateral hypothalamus that, when activated, prioritize survival over other ...

Excited to present our study in ‪@natneuro.nature.com‬: a deep brain pathway that triggers safety-driven movement—overriding needs like finding food or social contacts. A look into how the brain weighs deep instincts. Congrats to all and first author @nkrauth.bsky.social. shorturl.at/toYFN

Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!

mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice - Nature Aging Age-related hearing loss (ARHL) is a prevalent and complex disorder in older adults. Guo et al. identify human antigen R as a regulator of ARHL in aged mice and demonstrate that cochlear human antigen...

Coauthors include 2012 Emerging Research Grants scientist Renjie Chai PhD 👏👏 >> www.nature.com/articles/s43...