GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1
21.09.2025 12:47 — 👍 0 🔁 1 💬 0 📌 1@yizhoueugene.bsky.social
Researcher;System Medicine,developmental plasticity in nervous system cancers, psoriatic skin ;@Karolinska Inst. , @Wihuri Inst. & Univ. of Helsinki
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1
21.09.2025 12:47 — 👍 0 🔁 1 💬 0 📌 1Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!
22.09.2025 06:14 — 👍 0 🔁 0 💬 0 📌 0A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell
Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...
10.09.2025 14:25 — 👍 3 🔁 1 💬 0 📌 0Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
02.06.2025 17:20 — 👍 18 🔁 14 💬 0 📌 0Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz
29.05.2025 11:28 — 👍 16 🔁 6 💬 1 📌 2If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...
20.05.2025 17:13 — 👍 18 🔁 6 💬 0 📌 0🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
Epichrom 2025 !
After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.
Registration is free of charge
www.bartosovic-lab.com/epichrom
Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀
12.05.2025 15:13 — 👍 1 🔁 0 💬 0 📌 0Thank you, Susanne! Your help made this possible.
10.05.2025 10:52 — 👍 1 🔁 0 💬 0 📌 09/9🙏 Thanks to our collaborators:
@schlisio-lab.bsky.social
, Prof. Arthur Tischler (@tuftsmedicalcenter.bsky.social), Prof. Ronald de Krijger (
@themaximacenter.bsky.social
), and all the other amazing team members!
8/9 Our enhanced neural-network tool, scCAMEL, now aligns cross-species, multimodal data in a single workflow—empowering comprehensive mapping of tumor plasticity. sccamel.readthedocs.io/en/latest/
09.05.2025 22:04 — 👍 0 🔁 0 💬 1 📌 07/9 Spatial maps reveal clonal pockets of bridge & neural‑crest‑like cells encircled by TAMs & CAFs that sustain aggressiveness—micro‑environment is a Dev. state‑specific partner‑in‑crime.
09.05.2025 22:04 — 👍 0 🔁 0 💬 1 📌 06/9 Functional hits 👉 E2F7-networks fuel de‑differentiation, while HMX1 can force differentiation—unless MYCN amplification blocks it.---> Dev. state‑specific vulnerabilities = therapeutic targets.
09.05.2025 22:03 — 👍 0 🔁 0 💬 1 📌 05/9 🔑 Enhancer–gene regulatory networks uncover 121 core TF gene patterns organized into five principal patterns: Cell Cycle, ADRN-meta, ADRN-neu, Mes-Prog, and Mes-immune.
09.05.2025 22:03 — 👍 1 🔁 0 💬 1 📌 04/9 The enhancer‑primed epigenetic landscape gives neuroblastoma cells the "latent" capacity to shift between developmental programs.
09.05.2025 22:03 — 👍 0 🔁 0 💬 1 📌 03/9 We traced 7 NBL cell states back to the trunk neural crest lineage. A previously less-appreciated “bridge” state acts as the hub for state switching and, together with neural‑crest‑like cells, dominates high‑risk NBL.
09.05.2025 22:03 — 👍 0 🔁 0 💬 1 📌 02/9 In collaboration with
@patrikernfors.bsky.social
and Jian Wang’s team, we integrated single-cell and spatial transcriptomics from patient tumors and scRNA+ATAC data from mouse spontaneous models to construct a high-resolution disease atlas.
1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
Join us at the Nobel Symposium
Multiple Sclerosis: Past, Present and Future Treatment
June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden
free registration at:
jirango.com/cview/web/f0...
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.
www.nature.com/articles/s41...
New mug, #science_doesn’t_care_what_U_believe
13.03.2025 14:42 — 👍 0 🔁 0 💬 0 📌 0