Yizhou Hu(Eugene)

GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1

Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!

A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell

Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...

Postdoctoral studies in single-cell and computational biology Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research?  A postdoctoral position is available in the laboratory of Professor Francois

Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...

Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach Using an algorithm, highly optimized error-robust codebooks for spatial transcriptomic methods can systematically be produced.

If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...

Brain Tumor Plasticity A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...

🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social

Few spots available. Register here: ui.ungpd.com/Events/ed387...

Epichrom 2025 !

After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.

Registration is free of charge
www.bartosovic-lab.com/epichrom

Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀

Thank you, Susanne! Your help made this possible.

9/9🙏 Thanks to our collaborators:
@schlisio-lab.bsky.social
, Prof. Arthur Tischler (@tuftsmedicalcenter.bsky.social), Prof. Ronald de Krijger (
@themaximacenter.bsky.social
), and all the other amazing team members!

8/9 Our enhanced neural-network tool, scCAMEL, now aligns cross-species, multimodal data in a single workflow—empowering comprehensive mapping of tumor plasticity. sccamel.readthedocs.io/en/latest/

7/9 Spatial maps reveal clonal pockets of bridge & neural‑crest‑like cells encircled by TAMs & CAFs that sustain aggressiveness—micro‑environment is a Dev. state‑specific partner‑in‑crime.

6/9 Functional hits 👉 E2F7-networks fuel de‑differentiation, while HMX1 can force differentiation—unless MYCN amplification blocks it.---> Dev. state‑specific vulnerabilities = therapeutic targets.

5/9 🔑 Enhancer–gene regulatory networks uncover 121 core TF gene patterns organized into five principal patterns: Cell Cycle, ADRN-meta, ADRN-neu, Mes-Prog, and Mes-immune.

4/9 The enhancer‑primed epigenetic landscape gives neuroblastoma cells the "latent" capacity to shift between developmental programs.

3/9 We traced 7 NBL cell states back to the trunk neural crest lineage. A previously less-appreciated “bridge” state acts as the hub for state switching and, together with neural‑crest‑like cells, dominates high‑risk NBL.

2/9 In collaboration with
@patrikernfors.bsky.social
and Jian Wang’s team, we integrated single-cell and spatial transcriptomics from patient tumors and scRNA+ATAC data from mouse spontaneous models to construct a high-resolution disease atlas.

Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…

1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...

Join us at the Nobel Symposium

Multiple Sclerosis: Past, Present and Future Treatment

June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden

free registration at:

jirango.com/cview/web/f0...

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

New mug, #science_doesn’t_care_what_U_believe