Kacy Gordon

Kacy Gordon

@kacylynn.bsky.social

320 Followers 490 Following 18 Posts Joined Oct 2023
3 weeks ago
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Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line Summary: Pre-dauer starvation arrests gonad growth, reduces presentation of the germline niche cue LAG-2, and diminishes future reproductive success. Dauer recovery rapidly restores LAG-2 ligand and g...

Excited to share that GMB grad student Fred Koitz's paper is published @dev-journal.bsky.social Fred is graduating soon, and I am recruiting a postdoc to continue the work. Please reach out if you're interested, and share if you know folks who might be!
journals.biologists.com/dev/article/...

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1 month ago

Excited to see this out in the world. The CGC is launching a curated strains collection, the first being protein degradation systems and this is a pilot primer to pair with it authored by myself, Dave Reiner, Ann Rougvie, and Aric Daul. We review the state of the field and provide use guidance (1)

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3 months ago

Chapel Hill is a great place to do biology and a great place to live. Start early in 2026 to maximize overlap with three senior grad students who are getting ready to move on to their own postdocs. Please share widely!

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3 months ago

I am hiring a postdoc (or two!) to work on C. elegans reproductive system development. Our MIRA funds work on cell size, migration, and niche signaling. Our CAREER funds work on regulation of gonad growth, degrowth, and regeneration during and after starvation

unc.peopleadmin.com/postings/310...

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4 months ago
Graphical abstract describing the main findings. Top, Nanog, Pou5f3, and Sox19b (NPS) work together for cellular reprogramming following fertilization of the egg and sperm in the embryo's maternal-to-zygotic transition. Clearance of the maternal program, plus activation of the zygotic and late zygotic genes expression programs later in development, together will enable gene expression programs towards cellular differentiation.
In maternal-zygotic NPS (mzNPS) mutant embryos, there is a failure of reprogramming and subsequently no gastrulation. However, when mzNPS embryonic cells are transplanted into wild type embryos, some cells survive and form mixed cell states, likely due to failed nuclear and cytoplasmic reprogramming. We find that some gene expression states, including primordial germ cell-like and motoneuron-like cell states, are able to develop in vivo, bypassing the loss of NPS-mediated embryonic reprogramming.

What cell states are possible when they are missing key factors - Nanog, Pou5f3 (Oct4), & Sox19b (Sox2) - that are required for the first embryonic reprogramming steps? Follow along with our latest publication, finally out at doi.org/10.1016/j.ce... #devbio #reprogramming #zebrafish #embryo (1/6)

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4 months ago

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

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5 months ago

Thanks Mark and Maureen! It was really fun to pull everything together.

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5 months ago
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The @uncchapelhill.bsky.social Department of Biology is searching for tenure-track Assistant Professor in Plant Molecular Biology. Chapel Hill is a wonderful place and Biology is an amazing group of people. To apply, see:
unc.peopleadmin.com/postings/307...

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5 months ago

Thanks Mark, Eric and Rob set the bar high! I'm excited to get to tell everyone what we've been up to.

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5 months ago
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Unique genetic bases of repeated life-history divergence associated with high altitude adaptation in Mimulus perennials Understanding evolutionary repeatability is a central question in biology, as it informs how predictably organisms respond to similar selection pressures. However, the extent to which phenotypic repea...

This was a HUGE effort, taking years of diligent work. Hongfei was a true leader, and I'm really proud of this cool piece. We'd love any feedback y'all might have. www.biorxiv.org/content/10.1...

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5 months ago
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The Braendle Lab in Nice, France is hiring two postdocs to study nematode genetics, evolution, and ecology. Start Jan–Jul 2026. Deadline Nov 30, 2025. Apply: christian.braendle@univ-cotedazur.fr

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6 months ago
Sarah holds up a brightly colored eel calendar with a moray, ribbon eel, splendid garden eels, and American and European eels, in front of some plants on the sidewalk

Last year we sold 5x more advent calendars than we have this August. Advent calendars are the biggest thing that keep the lights on at Skype a Scientist so this makes me a bit nervous!

These calendars are bright and cute and are full of really fun information about eels!

Get one here: EelFacts.net

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7 months ago
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2025 Rad Awards: Dr. Sarah McAnulty Philadelphia biologist Sarah McAnulty brings science to the masses in classrooms, through burlesque, at meet-ups and on telephone poles

I profiled @sarahmackattack.bsky.social for @thephilacitizen.bsky.social! thephiladelphiacitizen.org/2025-rad-awa...

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7 months ago
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Junior, Assistant, or Associate Specialist – Xue Lab University of California, Irvine is hiring. Apply now!

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601

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8 months ago
A map of the United states titled "United States of Science 2025" with the skype a scientist logo and 2000 tiny empty circles spread out across the USA. States with low population numbers have fewer than where there are more people.

Whew, ok, with a few hours to spare, the 2025 classroom map is ready! The 7th annual United States of Science competition starts tomorrow.

If you wanna get your region off to a head start, just between us night owls, here's that link 😘

givebutter.com/USS2025

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9 months ago

We worked our way down from this organismal fitness phenotype to rapid, environmentally responsive signaling protein dynamics in the stem cell niche.

I'm so proud of Fred, and Camille Miller, and excited about the new line of research that this project opened up for us!

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9 months ago

It all started as a rotation project that identified that early dauers (the first to form under conditions of starvation and crowding) had large gonads with lots of germ cells, while "late dauers" from old, long-starved plates had small gonads with few germ cells, and had fewer offspring post-dauer.

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9 months ago

This project took a few twists and turns, until a careful and clever experiment of Fred's blew it wide open (see Figure 2). It was kind of a dream experience, to have a student present elegant and irrefutable evidence that changed the whole direction of the study.

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9 months ago

I'm happy to share this preprint by first author Fred Koitz, a Genetics and Molecular Biology grad student in my lab! Fred came into the lab with an interest in dauer, and I am interested in gonad development, so we thought we'd start studying dauer gonad development.

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9 months ago
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Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

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10 months ago

Engineering the C. elegans genome with a nested, self-excising selection cassette https://www.biorxiv.org/content/10.1101/2025.05.01.651742v1

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10 months ago
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a netflix ad shows a woman talking to another woman at a vending machine ALT: a netflix ad shows a woman talking to another woman at a vending machine

We're hiring an assistant prof in global change ecology! Apply!!! We're vibrant, supportive, and interdisciplinary EEB community!

Plz note the weird dates: We're reviewing applications beginning on ✨August 15th✨. I'm part of the SC and happy to answer questions!

apply.interfolio.com/164677

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10 months ago

Congratulations Talia!

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10 months ago

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us all safe and healthy

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11 months ago
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Demographic history, genetic load, and the efficacy of selection in the globally invasive mosquito Aedes aegypti Abstract. Aedes aegypti is the main vector species of yellow fever, dengue, Zika and chikungunya. The species is originally from Africa but has experienced

Excited to see the final version of this paper with @samurscicop.bsky.social and Daniel Matute out in @genomebiolevol.bsky.social!

We took a dive into the complicated demographic history of Aedes aegypti mosquitoes and its impact on the distribution of genetic diversity
doi.org/10.1093/gbe/...

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1 year ago

In addition to revealing an important player in niche migration, our paper also demonstrates the utility of published single-cell datasets for hypothesis generation. Thanks to Eyleen O'Rourke and Abbas Ghaddar for their really useful study and app! wormseq.org www.science.org/doi/10.1126/...

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1 year ago

MIG-21 is known to regulate the polarity of cell migration in response to a Wnt gradient and in a network with Netrin receptors in Q neuroblasts, but its function in the germline niche was masked by redundancy in functional screens for niche migration defects.

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1 year ago

New preprint! First author Xin Li (QBio UNC) used a scRNA-seq study to find that mig-21 is highly and specifically expressed in the C. elegans germline stem cell niche, but it had no known function there. We found that it integrates Wnt and Netrin signaling to regulate A/P and D/V cell migration.

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1 year ago

Thanks so much!

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1 year ago

Oooh where did you get the plastic objective covers?

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