Kaitlin McCreery

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

You don't understand that's my emotional support bag of loose PCR tubes

Sleep matters for joint health!

In our new paper led by Dr Liz Rowlands, we studied sleep habits of 500,000 people. Osteoarthritis risk was highest with <6 hours of nightly sleep and significantly increased by shift work.
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Biophysics of organoids In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...

Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics

Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

Amazing to have our work finally out!!! 😍🤩😍

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression - npj Biological Physics and Mechanics npj Biological Physics and Mechanics - Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...

Cool new method to integrate mechanics and transcriptomics, can’t wait to try it out 🤓 Congratulations Adrien @halloulab.bsky.social & team!

Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!

#Mechanobiology #DevelopmentalBiology

UVM Achieves Prestigious Carnegie R1 Designation, Joining Highest Level of U.S. Research Institutions | Office of the Vice President for Research (OVPR) | The University of Vermont

UVM is now a Carnegie R1 institution! This achievement reflects decades of dedication to cutting-edge research, innovation, and excellence. With over $260M in funding (FY24) and groundbreaking projects, we're on the course for an even more ambitious future! #UVMresearch