Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
11.10.2025 07:04 β π 35 π 14 π¬ 2 π 1@mccreery.bsky.social
We study the cell nucleus and the tissue microenvironment, driving dynamic cell mechanics. Multiscale Bioengineering Lab at College of Engineering & Mathematical Sciences at the University of Vermont. mccreerylab.com
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
11.10.2025 07:04 β π 35 π 14 π¬ 2 π 1π«NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A π§΅...
01.10.2025 18:20 β π 222 π 68 π¬ 11 π 18Amazing to have our work finally out!!! ππ€©π
29.09.2025 18:38 β π 36 π 7 π¬ 1 π 0Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our paper is out in Nature Cell Biology! π Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world π₯
29.09.2025 22:27 β π 7 π 3 π¬ 0 π 0How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
18.09.2025 18:12 β π 12 π 5 π¬ 2 π 0Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
22.07.2025 17:10 β π 126 π 53 π¬ 11 π 3How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...
12.05.2025 07:25 β π 49 π 12 π¬ 0 π 0Cool new method to integrate mechanics and transcriptomics, canβt wait to try it out π€ Congratulations Adrien @halloulab.bsky.social & team!
18.03.2025 07:12 β π 21 π 3 π¬ 1 π 0Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!
#Mechanobiology #DevelopmentalBiology
UVM is now a Carnegie R1 institution! This achievement reflects decades of dedication to cutting-edge research, innovation, and excellence. With over $260M in funding (FY24) and groundbreaking projects, we're on the course for an even more ambitious future! #UVMresearch
13.02.2025 16:32 β π 20 π 6 π¬ 0 π 3