Nihar Desai MD, DM

A bit of a #HumbleBrag
The Hans Messner AlloBMT program @hansbmt.bsky.social just infused the 200th allograft of this fiscal year. A new record for us and for Canada! #bmtsm
@tomam04.bsky.social @nihardesai7.bsky.social @uhnresearch.bsky.social

Nihar Desai: Central Nervous System Manifestations of Graft-Versus-Host Disease - OncoDaily Nihar Desai: Central Nervous System Manifestations of Graft-Versus-Host Disease / cancer, central nervous system, CNS, European Journal of Hematology, fight

Central Nervous System Manifestations of Graft-Versus-Host Disease - Nihar Desai
@nihardesai7.bsky.social

oncodaily.com/science/2581...

#Cancer #CentralNervousSystem #Medicine #Health #CancerResearch #Oncology #OncoDaily

Central venous catheter and thrombosis!

Reviewer 2 walking away after destroying the manuscript 😭😭

Nihar Desai: 25 years of imatinib - OncoDaily Nihar Desai: 25 years of imatinib / Brian J. Druker, cancer, imatinib, Nihar Desai, OncoDaily, Oncology

25 years of imatinib - Nihar Desai
@nihardesai7.bsky.social

oncodaily.com/drugs/nihar-...

#Cancer #CancerResearch #CancerTreatment #Medicine #Health #Oncology #OncoDaily

Sorry, what? This happens??

This 35 yr old man is always tired 😭

You find 👇🏽 on clinical examination. He also has bradycardia 🫀

Ddx?
Management?

📸 @nejm.org

Out now in Blood Advances 🙌🏽

Our work from Princess Margaret Cancer Centre evaluating the role of PTCy in matched sibling donor allogeneic transplantation!

Also read this excellent commentary by my good friend @nicogagelmann.bsky.social 👇🏽

ashpublications.org/bloodadvance...

I am pleased to present 3 posters and chair a session at the EBMT annual meeting in Florence 🙌🏽

@hansbmt.bsky.social

What doesn’t evolve, goes extinct!!

If you don’t adapt new data, you’ll never improve patient care. No study is perfect, and none ever will be. What matters is critical appraisal of available literature and adapting it to improve patient care 🙏🏽

Can a D-dimer be used to diagnose DVT/PE?

NOOOOOOOOOOOOOOOOOOOO!

What else ⤴️D-dimer?
•Any infection
•Any inflammation
•Old age
•Cancer

Remember, D-dimer is a very sensitive test but NOT a very specific test 🙌🏽

It's not just the ⤵️EPO that causes anemia in patients with CKD

CKD = inflammation = ⤴️Hepcidin = ⤵️iron absorption = anemia

Blood loss during dialysis = iron deficiency anemia

CKD = ⤴️Uremic toxins = ⤵️red cell production

Anemia in CKD 👇🏽

We all know that CKD = ⤵️EPO

What's the mechanism?

The interstitial cells transdifferentiate into MYOFIBROBLASTS instead of EPO producing cells

⤵️ EPO producing cells = ⤵️EPO = Anemia 👇🏽

Fever + cytopenias + organomegaly ➡️ think HLH!

If you don't suspect HLH, you'll miss HLH 🙌🏽

Nice figure by Nguyen et al 👇🏽

doi.org/10.1038/s122...

The magic of stem cell transplantation for aplastic anemia 💪🏽

Before ➡️ After

📢 Happy to speak about the impact of ABO status on engraftment and survival after allogeneic transplant in the PTCy era at the Cochin Hematology Group annual meeting 🙌🏽

Ivermectin is a great drug for parasitic infections but it does NOT cure cancer.

Sincerely,
An oncologist

Clearance of Driver Mutations after Transplantation for Myelofibrosis | NEJM Allogeneic hematopoietic stem-cell transplantation is the only curative treatment for myelofibrosis. Driver mutations are the pathophysiological hallmark of the disease, but the role of mutation cl...

In a single-group, single-center study, clearance of driver mutations 30 days after bone marrow transplantation predicted long-term disease-free survival in patients with myelofibrosis. Read the full study results: nej.md/4fQNdKn

#MedSky

I do feel like we forget that a mere 100 years ago 20% of children in America just fucking died.

Now that the USA sucks, have you considered moving to USB?

Remember, the mentor - mentee relationship is a two way street. Mentees must learn to deliver what they've promised 🙌🏽

A mentor need not be your Prof. It could be anyone! A person you meet online, a friend, a senior colleague. It's also possible to have multiple mentors 🙏🏽

I ❤️ road trips!

Walking in to 2025 with my ❤️

I think vaccines had something to do with this 🤷🏼

One cannot manage a patient with febrile neutropenia without having a sound knowledge of medicine!

You need to know medicine before you step into a hematology unit! Period.

#MedSky / #SkyMed

Thou shalt not allow polio to come back you stupid fucks.

I’ve cared for infants who stopped breathing w/ pertussis.

School aged kids who died of flu or COVID.

And many of my patients can’t be vaccinated because they’re on chemotherapy or are immune compromised.

Vaccinations save lives of those who get them & those who cannot.

It’s that simple.