Brain structural and functional differences in anejaculation and sleep disorders: A functional magnetic resonance imaging‐based approach Background and aims Sleep disorders (SDs) have been identified as an independent risk factor for ejaculatory dysfunctions; yet the neurophysiological mechanisms underlying the comorbidity between an...

These findings shed light on how poor sleep may contribute to ejaculatory dysfunction and point toward new therapeutic paths.

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💤⚡ Can sleepless nights harm sexual health?

New research in Andrology reveals how men with anejaculation, with and without sleep disorders, show striking brain differences on fMRI.

A prospective study of semen quality and fecundability among North American couples planning pregnancy Background Few studies have prospectively evaluated semen quality (using the most up-to-date clinically relevant definitions) and fecundability (the per-cycle probability of conception). Objective.....

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Using at-home semen tests, researchers found that lower sperm concentration, total count, and motile sperm count were all linked to reduced chances of conception per cycle.

🧬 Real-world data. Clinically relevant thresholds. Insightful takeaways for reproductive health.

📉 Does semen quality predict time to pregnancy?

A new prospective study published in Andrology examines semen parameters and fecundability in over 700 North American couples trying to conceive.

Gonadotropin storage and trafficking Background Gonadotropins are synthesized in gonadotropes of the anterior pituitary, and they orchestrate reproductive function in vertebrates. LH and FSH share a common α-subunit that is non-covalen...

🔬 A deep dive into the cellular mechanics behind hormone storage and release – with real implications for female reproductive longevity.

🔗 Read it in Andrology: doi.org/10.1111/andr...

🚨 LH and FSH may come from the same cell – but they follow very different paths.

This new review traces the evolution and trafficking of gonadotropins from primitive fish to mammals, revealing how molecular tweaks to FSH secretion can boost ovulation and ovarian health.

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in repr.....

🔍 100+ fertility-linked proteins identified

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New clues in the quest to predict male fertility in boars 🐖💡

Proteomic profiling of pig seminal extracellular vesicles reveals dozens of proteins linked to sperm function, embryo development, and implantation. These biomarkers could improve boar selection in AI programs.

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index Background The constitutive Leydig cell hormone insulin-like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent ...

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🧊 Freezing damages more than you think.

🔍 A new study in Andrology reveals how slow freezing reshapes sperm chromatin deep inside the nucleus.

This tool could be a game-changer for assessing sperm quality in fertility clinics.

Epidemiology of hypospadias in China: A nationwide surveillance‐based study, 2010–2020 Background The prevalence of hypospadias varied internationally. However, epidemiological data on hypospadias in contemporary China remain limited. Objectives We aim to examine the epidemiological.....

This work highlights a concerning link between associated hypospadias and higher perinatal mortality.

🧬 These findings underscore the urgent need for further clinical and epidemiological research into causes and prevention.

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A new nationwide study published in Andrology reveals that the prevalence of hypospadias has significantly increased in China between 2010 and 2020.

🔍 Using data from over 11 million births, the research uncovers geographic and demographic disparities.

Why don’t ED drugs work for everyone?
A new study published in Andrology uncovers two promising drug targets using genetic tools and single-cell technology—paving the way for next-gen erectile dysfunction treatments beyond Viagra.
👉 Find out more: doi.org/10.1111/andr...

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How does the immune system shape the maturing testis? 🧬🧪
A new study maps the immune cells of the testis before and after sexual maturation — revealing dynamic immune remodeling, rare B cells, and key crosstalk between immune and androgen-producing cells.

Iron: essential for healthy testes — harmful when imbalanced. This new review explores how iron metabolism shapes spermatogenesis, testosterone production, and male fertility — and how both iron overload and deficiency can drive testicular dysfunction.

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Topological abnormalities of left middle orbital frontal gyrus and amygdala associated with hypoactive sexual desire disorder: A diffusion tensor imaging study Introduction Sexual desire has been found to be associated with brain areas involved in sexual excitation and inhibition. However, little is known regarding whether hypoactive sexual desire disorder...

These findings may point to a neural basis for low sexual desire and potential imaging biomarkers.

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New research uncovers disrupted brain connectivity in individuals with hypoactive sexual desire disorder. The study identifies topological abnormalities in the left middle orbital frontal gyrus and amygdala, key regions for sexual motivation and emotional regulation.

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice Background RIBC1 (RIB43A domain with coiled-coils 1) and RIBC2 (RIB43A domain with coiled-coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unic...

These findings highlight the subtle but critical cooperative role of microtubule inner proteins in sperm function.

Read the full article: doi.org/10.1111/andr...

New in Andrology

A renowned Japanese research group specializing in testis-specific gene knockouts reports that simultaneous loss of RIBC1 and RIBC2 in mice leads to reduced sperm motility and smaller litter sizes—despite no structural defects visible under TEM.

Engineered nanoparticles potentials in male reproduction Background The escalating prevalence of fertility problems in the aging population necessitates a comprehensive exploration of contributing factors, extending beyond environmental concerns, work-rel.....

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This review explores the potential of engineered nanoparticles to revolutionize how we treat testicular diseases. With their biocompatibility, targeting ability, and membrane-penetrating properties, nanocarriers could drastically improve drug delivery and treatment outcomes.

Can nanotechnology change the future of male fertility treatment?

As fertility challenges continue to rise—especially in aging populations—traditional treatments for testicular disorders often fall short due to side effects, invasiveness, and the tough-to-penetrate BTB.

Applications of spatial transcriptomics in studying spermatogenesis Spermatogenesis is a complex differentiation process that is facilitated by a series of cellular and molecular events. High-throughput genomics approaches, such as single-cell RNA sequencing, have b...

This approach is advancing our understanding of male infertility and helping pave the way for new diagnostic and therapeutic strategies.

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How can you use spatial transcriptomics to study spermatogenesis?

This review highlights how this technology is being used to study spermatogenesis by preserving tissue context—enabling researchers to explore spatial gene expression, cellular neighborhoods, and molecular changes in the testis.

Diabetes may impair the epididymis, disrupting sperm maturation at a critical stage.

This systematic review, published in Andrology, links high glucose, oxidative stress, and hormonal imbalance to epididymal dysfunction in both humans and mice.

Read the fully study: doi.org/10.1111/andr...

Initial motility and vitality predict the semen quality after long‐term cryostorage, even in patients with restricted ejaculate parameters Background Cryopreservation of human semen is the cornerstone for preserving male fertility before gonadotoxic therapy or in cases of high variability in semen parameters. This is particular crucial...

📦 Samples stored for up to two decades remained viable, proving that cryopreservation is a reliable long-term option, even when starting parameters are low.

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🧊 How well does sperm hold up in long-term storage?
New research published in Andrology shows that initial motility and vitality are key predictors of semen quality after years in cryostorage—even in patients with severely impaired semen parameters.

Dupless: Toward a patient‐friendly approach for erectile dysfunction nature differentiation – a study of 291 penile duplex Doppler ultrasound assessments Background Erectile dysfunction (ED) is a condition commonly classified as either psychogenic or organic. Traditional age-based categorizations are considered overly simplistic, yet many clinicians .....

This study underscores a crucial message: we need better, modern diagnostic tools to support men’s health.

📖 Read the full study here: doi.org/10.1111/andr...