Manav Pathania

Pathania lab team members sitting at a desk waiting for prosecco and some cake to be served up

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!

17.07.2025 20:21 — 👍 4    🔁 0    💬 0    📌 0

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

WOW!!!!!😱😮

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

14.07.2025 15:44 — 👍 41    🔁 6    💬 0    📌 1

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪

15.03.2025 13:21 — 👍 31    🔁 8    💬 0    📌 1

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length - Nature Communications Mice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This mode...

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length

👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.

www.nature.com/articles/s41...

14.02.2025 01:23 — 👍 9    🔁 2    💬 0    📌 0

From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.

31.01.2025 15:43 — 👍 4880    🔁 3136    💬 160    📌 295

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) …

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding

www.sciencedirect.com/science/arti...

15.01.2025 11:57 — 👍 3    🔁 0    💬 0    📌 0

Happy New Year photo 1

Happy New Year photo 2

Buon Anno!!

31.12.2024 23:41 — 👍 4    🔁 0    💬 0    📌 0

Family photo 1

Family photo 2

Family photo 3

Family photo 4

Merry Christmas!

26.12.2024 12:20 — 👍 2    🔁 0    💬 0    📌 0

Holiday lunch with the lab at The Graduate Cambridge photo 1

Holiday lunch with the lab at The Graduate Cambridge photo 2

Rounding out the year with the team

17.12.2024 16:27 — 👍 8    🔁 0    💬 0    📌 0

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

12.12.2024 18:56 — 👍 154    🔁 74    💬 12    📌 7

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

27.11.2024 22:17 — 👍 115    🔁 21    💬 12    📌 3

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
www.nature.com/articles/s41...

21.11.2024 13:19 — 👍 3    🔁 0    💬 0    📌 0

Hi, please could I be added?

20.11.2024 15:56 — 👍 0    🔁 0    💬 1    📌 0

Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.

18.11.2024 20:22 — 👍 6    🔁 0    💬 0    📌 0

A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Models of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...

Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance.
doi.org/10.1158/2159...

15.11.2024 18:12 — 👍 3    🔁 0    💬 0    📌 0

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

Incredible study now out in Nature, with long-term remission for pediatric glioma

Michelle Monje, Crystal Mackall et al

Well done to all the authors for this true tour de force!
🧪⚕️🩺

www.nature.com/articles/s41...

14.11.2024 19:16 — 👍 62    🔁 11    💬 1    📌 0

Oh no! Don't dwell on it too long, onwards and upwards!

11.11.2024 13:36 — 👍 1    🔁 0    💬 0    📌 0

FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma Abstract. Central nervous system neuroblastoma with FOXR2 activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and...

I reserved my first Bluesky post to mark another enjoyable and successful collaboration with the Jabado and Kleinman labs! Congrats to @selinjessa.bsky.social, Bhavyaa and Antonella on this cool paper!

doi.org/10.1158/0008...

07.11.2024 11:17 — 👍 6    🔁 2    💬 0    📌 0