Jennie Clough

Decoding γδ T cell-epithelial interactions in the human intestine in health and disease - MRC DTP The human gut epithelium performs vital absorptive functions, while simultaneously forming a physical barrier between the gut contents and the body. As such it is essential for health and its dysregul...

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids

Testing is free, discreet and easy - for more information on the RAPID-IBD study visit www.royaldevon.nhs.uk/about-us/res...

Do you have:

📌 Blood in your poo?
📌 Abdominal pain that won’t go away?
📌 Diarrhoea that can’t wait?

If you have experienced any of these symptoms, you may have a problem with your bowel health.

FREE testing kits are available for EX postcode residents aged 16–49 ➡️ bit.ly/IBDKit

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease Crohn's disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlyin...

🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease!

🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀

🧵 1/10
🔗 www.medrxiv.org/content/10.1...

Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...

Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪

Role of anti-diabetic medications in the management of MASLD Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a significant global health challenge due to its rising prevalence and strong association with metabolic syndrome and type 2 diab...

Read the paper here
fg.bmj.com/content/16/3/239

Overcoming the challenges of overtreating and undertreating inflammatory bowel disease Several therapeutic advances have been achieved over the past two decades for inflammatory bowel disease (IBD). The expanding therapeutic armamentarium and the increasingly ambitious treatment targets...

Today is #WorldIBDDay!

Some recent #IBD related highlights in the journal:

1) Overcoming the challenges of overtreating and undertreating inflammatory bowel disease
www.thelancet.com/journals/lan...

#gastrosky #ibdsky #medsky

Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response Nature Reviews Gastroenterology & Hepatology, Published online: 22 April 2025; doi:10.1038/s41575-025-01063-xInflammatory bowel disease (IBD) is an immune-mediated disease with substantial burden worldwide. In this Consensus Statement, a global multidisciplinary group of experts identify key priorities and recommendations to raise awareness and advance IBD care and research.

New online! Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response

Great to see our paper examining real-world applicability of telemonitoring interventions published in FG! Fantastic working with Dee Kumar, Kohi Gananandan, @jennieclough.bsky.social and Guy Robinson on this! #livertwitter #gitwitter

fg.bmj.com/content/early/2025/04/08/flgastro-2024-102997

Prevention and interception trials in inflammatory bowel disease: an international taskforce assessment on clinical trial design Therapeutic progress in inflammatory bowel disease (IBD) has hitherto focused on reducing inflammation to minimise long-term complications. However, strategies aimed at preventing IBD and attenuating ...

New Review - Honap et al - Prevention and interception trials in inflammatory bowel disease: an international taskforce assessment on clinical trial design

www.thelancet.com/journals/lan...

#GastroSky #MedSky #IBDSky

Survey: Priorities for Liver Cirrhosis Research Take this survey powered by surveymonkey.com. Create your own surveys for free.

Thanks to all that completed the first round of the UK CLIF JLA research priority setting process for decompensated cirrhosis - if you live with or care/work with patients with cirrhosis - please take some time to go through these research questions #livertwitter

www.surveymonkey.com/r/SMMF6XJ

Looking for an excellent & highly motivated postdoctoral researcher to join our team to develop an exciting project focused on the generation of beneficial Innate Lymphoid Cells #ILC for the treatment of Inflammatory Bowel Disease #IBD using #organoids. Please share!
www.kcl.ac.uk/jobs/109186-...

Plenty of discussion at #ECCO2025 on opportunities for AI in IBD care. But how do the vast electricity/water requirements of AI servers fit our #sustainability aims? Are there offsets we can make? Can we justify the data storage requirements of continuous monitoring?

Sadly no! It means I’m in the final year of specialty training in the British system

See also:

bmjopen.bmj.com/content/15/1...

Role of Mirikizumab in the Treatment of Inflammatory Bowel Disease—From Bench to Bedside Mirikizumab is a monoclonal antibody directed against the p19 subunit of interleukin (IL)-23 to inhibit its interaction with the IL-23 receptor. IL-23 is a key cytokine involved in initiating and perp...

www.mdpi.com/2077-0383/14...

GLP1 receptors are present on lots of cells, including cells of the immune system, so it is scientifically plausible (likely) they have effects outside of the benefits of weight loss.

Really enjoyed working on this review for Frontline Gastroenterology. How do anti-IL23 therapies work? What’s the evidence for their use in IBD? And is there any guidance on how we should position them in the treatment landscape?

fg.bmj.com/content/earl...