Jens Hjerling Leffler

Chief Executive Officer - New York City, New York (US) job with arXiv | 37961678 arXiv seeks its first CEO to champion open, free scientific discovery and guide the platform’s next chapter as an independent nonprofit.

arXiv to spin out as an independent non-profit. They are seeking a CEO jobs.chronicle.com/job/37961678...

What's My JND? Find your Just Noticeable Difference in colour perception. How small a colour difference can you actually see?

What's My JND? 0.0029
Can you beat it? www.keithcirkel.co.uk/whats-my-jnd...

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...

BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis

I am so happy for the recognition that my PhD supervisor and friend has received. Congratulations Patrik!

Post-doc positions in my lab. Come join us in Stockholm! ki.varbi.com/en/what:job/...
ki.varbi.com/en/what:job/...

A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.

🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
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🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠
She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?

🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨‍🎓

Our last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group!

Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠

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First paper from the lab is now online
@natneuro.nature.com !
We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

a netflix ad shows a woman in a blue dress ALT: a netflix ad shows a woman in a blue dress

Pet peeve: when someone invites you to a meeting but instead of sending a calendar invitation, they just send a zoom link in an email.

If you want profs to actually show up for meetings-- send a calendar invitation!

#AcademicSky #ScienceSky #MedSky #EpiSky

A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....

Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD

SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...

Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...

✨Hello folks!✨

We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦

"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"

🔗http://bit.ly/49syndi

Read our overview below!

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Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋

Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia

Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)

Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

Well done, and well deserved my friend!

Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons Objective Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology o...

Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...

How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social

Understanding why antidepressants don't always work 🧠🛡️
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.

📖https://bit.ly/469cXyI

New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Wow

Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions

ki.se/en/about-ki/...

Professor of Pharmacology - Uppsala University Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...