Albert Pol Lab

Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids The vital process of cellular fatty acid metabolism involves uptake, metabolic trapping and storage of long-chain fatty acids (LCFAs) in different lipid species. Although several different enzymes lik...

www.biorxiv.org/content/10.6...

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098

how beautiful!

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social)
that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more.
For details, visit: journals.biologists.com/jcs/pages/re...

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO Sixty-nine new members join the community of leading life scientists in Europe and beyond

Congratulations to newly elected @embo.org members

Special shout out to friends & colleagues: Andy Oates, Jody Rosemblatt & Pete Currie

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO share.google/9z7IS2lZBmll...

Triglycerides are an important fuel reserve for synapse function in the brain - Nature Metabolism Kumar et al. show that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function.

Well what do you know!? This might be the most interesting unorthodox orthodox metabolism paper this year.

The #MembraneTrafficking online seminars are back this Thursday (June 26th, 5pm CEST). We'll hear from @jnuechel.bsky.social about how to find the right partner for a TANGO, and from Maohan Su about the organizational principles of the Golgi. @ishier.bsky.social @franbottanelli.bsky.social

Happy summer!! A new issue of #cebooc is here! Read the latest paper on oocyte cell biology here:

biomed.news/bims-cebooc/...

Thanks @biomednews.bsky.social for preselecting!

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9

What an inspiring morning at the CatCat Symposium! Thank you so much for inviting me @gallegolab.bsky.social and @felixmendu.bsky.social, it's been a pleasure visiting you in Barcelona 😊

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

We are looking for a PhD candidate starting on the 01-10-2025. The project aims to understand how the host cells use copper and oxidative species to fight Salmonella infection and how this pathogen evades this antimicrobial response.

SHORT DEADLINE ! 20-04-2025
jobs.inrae.fr/en/ot-25517

ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability Tambrin et al. show that the Cdc42/Rac GAP ARHGAP12 promotes the flux of macromolecules across tight junctions by suppressing junctional actin assembly and tension via N-WASP and the Arp2/3 complex. T...

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...

Together with @gallegolab.bsky.social we are organizing the next CATCAT morning on "Dynamics in biology, from molecules to tissues", with an amazing lineup of local and international speakers. If in Barcelona on May 26th, don't miss it, it's free! www.catcat-celltissuebiology.cat/event/9th-ca...

A Postdoctoral Research position is available in the group of Lipid Trafficking and Disease (@idibaps.bsky.social Barcelona) to participate in the ERC granted project ‘Lipid droplets as innate immunity hubs’. @albertpol.bsky.social @albertherms.bsky.social focalplane.biologists.com/cell-biology...

New link www.clinicbarcelona.org/uploads/medi...

Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...

this is how it feels to reach 30 MILLION users!!!

JCS Editor-in-Chief @drmichaelway.bsky.social introduces our new Associate Editors.

We are delighted to welcome Sophie Acton @actonlab.bsky.social, Pedro Carvalho, @guijacquemet.bsky.social, @ckirchhelle.bsky.social and Aryeh Warmflash to the JCS team.
journals.biologists.com/jcs/article/...

This is just a reminder that the #cancermetabolism and #mitochondrialbiology community is ever-growing, and the third starter pack is becoming very juicy.

Starter pack 1: go.bsky.app/VavECSX

Starter pack 2: go.bsky.app/CH1MctZ

Starter pack 3: go.bsky.app/7Uwa6fb

We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇
www.clinicbarcelona.org/uploads/medi...

Zebrafish Ph.D scholarships available in Brisbane, Australia
#zebrafish

2 PhD positions are available under the supervision of Dr Thomas Hall and Dr Harriet Lo at the IMB, University of Queensland, Brisbane, Australia with negotiable start time during 2025

Further details in the thread below

Check out this preprint from collaborator Lance Johnson @johnsonlab.bsky.social and team characterizing the APOE3 vs E4 #LipidDroplet -ome! Some interesting Easter eggs in there 🐇🥚😉