Uma Mohan

Join us for this exciting talk today at noon!
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Registration link for mailing list:
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Cholinergic blockade reveals role for human hippocampal theta in encoding but not retrieval Cholinergic dysfunction is a hallmark of Alzheimer's disease and other memory disorders. Yet, the neurophysiological mechanisms linking cholinergic signaling to memory remain poorly understood. In thi...

Hi Bluesky! First post here. Kicking things off with a new preprint.

🧠 Using human iEEG + pharmacology, we asked: is hippocampal theta required for retrieval?

Turns out it’s not. Instead, it may reflect a reinstated encoding mode.

Thread below.
www.biorxiv.org/content/10.1...

The talk will begin at 8:00am in Newcastle, Australia (AEST), which corresponds to 6:00 PM New York time (ET) due to daylight saving adjustments. Thank you for your understanding. @drbreaky.bsky.social

Join us for this exciting talk tomorrow! Note the start time at 5pm ET.
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Closed-loop control of theta oscillations enhances human hippocampal network connectivity - Nature Communications Closed-loop brain stimulation of the human hippocampal theta rhythm produces lasting enhancement of network communication. This implicates theta rhythms in human hippocampal network communication and ...

Closed-loop control of theta oscillations enhances human hippocampal network connectivity
www.nature.com/articles/s41...
#neuroscience

Don't miss this awesome talk in week and a half! DM for zoom info

Aperiodic activity as a biomarker of seizures and neuromodulation Mounting evidence suggests the efficacy of neuromodulation for epilepsy is mediated by network remodeling and neural state. Epilepsy network related p…

Cool new paper showing how the aperiodic component of the spectrum of activity recorded chronically in patients with closed-loop stimulation devices could predict their seizures; importance of multidien cycles.

www.sciencedirect.com/science/arti...

Traveling waves in the human visual cortex: An MEG-EEG model-based approach Author summary Brain oscillations, thought to be crucial for many cognitive processes, might actually be waves that travel across the brain’s surface. Understanding these traveling waves is notoriousl...

New paper out in @plos.org Computational Biology! 🚨
We present a model-based approach to study traveling waves using MEG/EEG - no invasive recordings needed! Work done at the INCC, @upcite.bsky.social with @lauradugue.bsky.social, G Merolz, @rewaniw.bsky.social & D Heeger
/1
tinyurl.com/56dpd922

What do neural travelling waves tell us about information flow? In many behavioral conditions, neural activity propagates within and across brain regions as traveling waves, revealing the importance of analyzing spatiotemporal dynamics in electrophysiological data...

www.biorxiv.org/content/10.1...
"What do neural travelling waves tell us about information flow?"

A new preprint is out, with Antoine Grimaldi, Fredo Chavane and @martinavinck.bsky.social

Macroscale traveling waves evoked by single-pulse stimulation of the human brain Understanding the spatiotemporal dynamics of neural signal propagation is fundamental to unraveling the complexities of brain function. Emerging evidence suggests that cortico-cortical evoked potentia...

New paper from our group showing how neural traveling waves can be evoked by stimulation of the human brain.

www.jneurosci.org/content/earl...

Top-down and bottom-up interactions rely on nested brain oscillations to shape rhythmic visual attention sampling The brain processes sensory information through oscillatory gamma oscillations, while top-down control from higher-order areas is implemented through alpha/beta oscillations. How do these rhythms inte...

Nice paper showing beta/gamma doing that top-down/bottom-up thing again.
Top-down and bottom-up interactions rely on nested brain oscillations to shape rhythmic visual attention sampling
doi.org/10.1371/jour...
#neuroscience

In @elife.bsky.social: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala doi.org/10.7554/eLif...

Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks - Nature Communications How brain networks organize and interact based on their hierarchical position remains poorly understood. Momi, Wang et al find that high-order brain networks show stronger responses to stimulation and...

Absolutely incredible work by Davide Momi, John Griffiths,and a stellar team of neuroscientists with a multidimensional view of brain dynamics.

This work gives us a WHOLE BRAIN map of excitability.

www.nature.com/articles/s41...

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Working memory readout varies with frontal theta rhythms Increasing evidence suggests that attention varies rhythmically, phase-locked to ongoing cortical oscillations. Here, we report that the phase of theta oscillations (3 to 6 Hz) in the frontal eye fiel...

New results!
Working memory is read out via a theta (3-6 Hz) traveling wave sweeping across cortex.
Working memory readout varies with frontal theta rhythms
www.biorxiv.org/content/10.1...
#neuroscience

Join us for this exciting talk tomorrow!
Register for the mailing list or DM us for the zoom link
forms.gle/5Q4CPqTHAchH...

Don't miss this awesome talk next week! DM for zoom info

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks - Nature Neuroscience The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase order is linked...

Science Alert 🚨: Our paper is now out in @natureneuro.bsky.social - We show that the firing phase of neurons in human MTL doesn’t reflect the order of events, challenging a long-standing theory of human memory.
nature.com/articles/s41593-025-01893-7

Human insula neurons respond to simple sounds during passive listening The insula is critical for integrating sensory information from the body with that arising from the environment. Although previous studies suggest that posterior insula is sensitive to sounds, auditor...

Our new preprint is up now, wherein we directly record from a relatively large population of single neurons in human insula, as well as primary auditory cortex, while intracranial participants passively listen to simple sounds (tones/clicks). doi.org/10.1101/2025... (1/5) 🧠📈🧵👇

In the physical world, almost all information is transmitted through traveling waves -- why should it be any different in your neural network?

Super excited to share recent work with the brilliant @mozesjacobs.bsky.social: "Traveling Waves Integrate Spatial Information Through Time"

1/14

Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...

🚨 New lab paper!🚨

A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social

We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇

www.nature.com/articles/s41...

On the origin of memory neurons in the human hippocampus The hippocampus is essential for episodic memory, yet its coding mechanism remains debated. In humans, two main theories have been proposed: one suggests that concept neurons represent specific elemen...

New manuscript published! ✍️👀

Concept neurons evolve from index neurons through overlapping memories.

Check it out here: www.cell.com/trends/cogni... 1/15

Join us tomorrow at noon! DM for zoom link

The link for this position had gone down for a bit; it's back up, and I am still looking for a postdoc excited to work with human intracranial data.

Well-suited for animal electrophysiologists looking to jump to human data; all that's required is coding expertise and signal processing experience!

Don't miss this awesome talk next week!

🧠 We are #hiring! Postdoc @stanfordmedicine.bsky.social: help us develop closed-loop EEG platforms to improve TMS treatment for depression! Coding and neuroscience / engineering backgrounds required. Join our team! precisionneuro.stanford.edu email: ckeller1@stanford.edu

🔗 Contact your representatives using SfN’s Action Alert Center: bit.ly/413khdN

#NeuroSky

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Really proud to see my postdoc work out!!

We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging

www.science.org/doi/10.1126/...