Uma Mohan

Thank you for your understanding as we reschedule. It'll certainly be worth the wait to hear from Dr. Vishnu Sreekumar next week.

Join us on October 14th at 10:30am ET (8pm IST)!
Please note the time
@vishnusreekumar.bsky.social

Dear WaveClub Members,
I apologize for the late notification, but due to unforeseen circumstances, we will have to reschedule today's talk.
Thank you for your understanding.

Join us for this exciting talk this morning at 10:30am EST (8pm IST)?
DM us for zoom link

Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike re…

Neuropixels Ultra!

By @steinmetzneuro.bsky.social, who led a big collaboration

www.sciencedirect.com/science/arti...

Looking forward to hearing about new cortical traveling wave work across scales next week from @vishnusreekumar.bsky.social

Ripple contributions to human memory: making the spiking content count - Nature Reviews Neuroscience In animal models, transient high-frequency oscillations in synchronized neural activity, known as ripples, have been linked to memory. Reithler et al. assess the current evidence for a contribution of...

Ripple contributions to human memory: making the spiking content count — a Review by Joel Reithler, Kelsey K. Sundby & Kareem A. Zaghloul

www.nature.com/articles/s41...

#neuroscience #neuroskyence

Neuronal theta-phase locking increased during periods of elevated theta power, when aperiodic activity exhibited steeper slopes, and when clear theta oscillations were detected. Theta-phase locking was similarly strong during the successful and unsuccessful encoding and retrieval of memories. Some neurons changed their preferred theta phases between encoding and retrieval.

Excited to share our new paper on theta-phase locking of single neurons during human spatial memory:

www.nature.com/articles/s41...

With @lukaskunz.bsky.social, Joshua Jacobs, and our colleagues from the University of Freiburg

Join us for this exciting talk today at noon!
DM us for the zoom link

Looking forward to hearing about new traveling wave work next week from @kjayant.bsky.social

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects https://www.biorxiv.org/content/10.1101/2025.07.31.667730v1

Join us for this exciting talk today at noon!
DM us for the zoom link
Registration link for mailing list:
forms.gle/5Q4CPqTHAchH...

Don't miss this awesome talk next week! DM for zoom info

Cholinergic blockade reveals role for human hippocampal theta in encoding but not retrieval Cholinergic dysfunction is a hallmark of Alzheimer's disease and other memory disorders. Yet, the neurophysiological mechanisms linking cholinergic signaling to memory remain poorly understood. In thi...

Hi Bluesky! First post here. Kicking things off with a new preprint.

🧠 Using human iEEG + pharmacology, we asked: is hippocampal theta required for retrieval?

Turns out it’s not. Instead, it may reflect a reinstated encoding mode.

Thread below.
www.biorxiv.org/content/10.1...

The talk will begin at 8:00am in Newcastle, Australia (AEST), which corresponds to 6:00 PM New York time (ET) due to daylight saving adjustments. Thank you for your understanding. @drbreaky.bsky.social

Join us for this exciting talk tomorrow! Note the start time at 5pm ET.
DM for the zoom link

Closed-loop control of theta oscillations enhances human hippocampal network connectivity - Nature Communications Closed-loop brain stimulation of the human hippocampal theta rhythm produces lasting enhancement of network communication. This implicates theta rhythms in human hippocampal network communication and ...

Closed-loop control of theta oscillations enhances human hippocampal network connectivity
www.nature.com/articles/s41...
#neuroscience

Don't miss this awesome talk in week and a half! DM for zoom info

Aperiodic activity as a biomarker of seizures and neuromodulation Mounting evidence suggests the efficacy of neuromodulation for epilepsy is mediated by network remodeling and neural state. Epilepsy network related p…

Cool new paper showing how the aperiodic component of the spectrum of activity recorded chronically in patients with closed-loop stimulation devices could predict their seizures; importance of multidien cycles.

www.sciencedirect.com/science/arti...

Traveling waves in the human visual cortex: An MEG-EEG model-based approach Author summary Brain oscillations, thought to be crucial for many cognitive processes, might actually be waves that travel across the brain’s surface. Understanding these traveling waves is notoriousl...

New paper out in @plos.org Computational Biology! 🚨
We present a model-based approach to study traveling waves using MEG/EEG - no invasive recordings needed! Work done at the INCC, @upcite.bsky.social with @lauradugue.bsky.social, G Merolz, @rewaniw.bsky.social & D Heeger
/1
tinyurl.com/56dpd922

What do neural travelling waves tell us about information flow? In many behavioral conditions, neural activity propagates within and across brain regions as traveling waves, revealing the importance of analyzing spatiotemporal dynamics in electrophysiological data...

www.biorxiv.org/content/10.1...
"What do neural travelling waves tell us about information flow?"

A new preprint is out, with Antoine Grimaldi, Fredo Chavane and @martinavinck.bsky.social

Macroscale traveling waves evoked by single-pulse stimulation of the human brain Understanding the spatiotemporal dynamics of neural signal propagation is fundamental to unraveling the complexities of brain function. Emerging evidence suggests that cortico-cortical evoked potentia...

New paper from our group showing how neural traveling waves can be evoked by stimulation of the human brain.

www.jneurosci.org/content/earl...

Top-down and bottom-up interactions rely on nested brain oscillations to shape rhythmic visual attention sampling The brain processes sensory information through oscillatory gamma oscillations, while top-down control from higher-order areas is implemented through alpha/beta oscillations. How do these rhythms inte...

Nice paper showing beta/gamma doing that top-down/bottom-up thing again.
Top-down and bottom-up interactions rely on nested brain oscillations to shape rhythmic visual attention sampling
doi.org/10.1371/jour...
#neuroscience

In @elife.bsky.social: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala doi.org/10.7554/eLif...

Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks - Nature Communications How brain networks organize and interact based on their hierarchical position remains poorly understood. Momi, Wang et al find that high-order brain networks show stronger responses to stimulation and...

Absolutely incredible work by Davide Momi, John Griffiths,and a stellar team of neuroscientists with a multidimensional view of brain dynamics.

This work gives us a WHOLE BRAIN map of excitability.

www.nature.com/articles/s41...

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Working memory readout varies with frontal theta rhythms Increasing evidence suggests that attention varies rhythmically, phase-locked to ongoing cortical oscillations. Here, we report that the phase of theta oscillations (3 to 6 Hz) in the frontal eye fiel...

New results!
Working memory is read out via a theta (3-6 Hz) traveling wave sweeping across cortex.
Working memory readout varies with frontal theta rhythms
www.biorxiv.org/content/10.1...
#neuroscience

Join us for this exciting talk tomorrow!
Register for the mailing list or DM us for the zoom link
forms.gle/5Q4CPqTHAchH...

Don't miss this awesome talk next week! DM for zoom info

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks - Nature Neuroscience The temporal order of events in working memory is thought to be reflected by ordered neuronal firing at different phases. Here the authors show that this is not the case and that phase order is linked...

Science Alert 🚨: Our paper is now out in @natureneuro.bsky.social - We show that the firing phase of neurons in human MTL doesn’t reflect the order of events, challenging a long-standing theory of human memory.
nature.com/articles/s41593-025-01893-7