Luisa F. Pallares

Thanks, Jesse! Yeah, we're doing the same here 🤔

That's frustrating. Specially because one could use the same argument for genetic regulation of the mean. I think organisms experience different microenvironments all the time, but how they deal with them is, at least in part, geno-dependent. Think developmental noise in symmetric structures.

You're right here, we could find plenty of examples of 'microenvironments' each species experiences, not necesarily more or less than the other... I guess I was thinking more in the sense of a plant which grows continuosly vs a relative static adult as a fly.

Ah! I hadn't seen this paper - it's brilliant, and extremely relevant for us now, as we are attempting something similar with higher order phenotypes (non molecular). Thanks for sharing!

(3/3) What do you mean with results of space biology data?

(2/3) So, we are thinking an active -but selective- mechanism is making transcription more accurate? more precise? This is mindblowing to me, because explaining an increase in variance can be done more easily, than a reduction...

(1/3) Hi Alexa, this gets more interesting because these developmental pathways not only remain robust (i.e. don't have variance changes) BUT they become less variable (i.e. significant reduction in variability compared to control conditions)

(2/2) Would you imagine there is more microenvironmental variation in Arabidopsis? or instead that plants are more sensitive to microenvironmental variation than flies?

(1/2) Hi Dan, yes, this is interesting. We also find tons of veQTL in non-stress conditions (~14% of genes with at least one veQTL), but not nearly as much as you did (~95% of genes).

Tons of questions regarding phenotypic variability/variance/robustness/noise remain unanswered, so, stay tuned! But for now, I leave you with the preprint www.biorxiv.org/content/10.6...

Despite our intuition, theory had already predicted that high phenotypic noise (high-variability alleles) might not always be detrimental [P.S. more on this in our next pre-print 😉]

BUT, things don't end up there🥁... Although it seems that we don't want to mess up too much with the degree of trancriptional noise of genes, a closer look suggests that, when noise-alleles exist, it is low-noise alleles that tend to be detrimental, specially under stressful conditions 🤯

Main finding #3: Variance-regulating loci (veQTL) seem to be subject to different selection pressures than the better known mean-regulating loci (eQTL) - What does this mean!? We think that overall, veQTL are under stronger 💪 negative selection than eQTL.

Main finding #2: Transcriptional variability is genetically regulated, we find widespread variance-eQTLs. However, the are only detected in stressful conditions. Yes, you are right (and Waddington too!) stress unmasks cryptic genetic variation🧬, but not only for mean, but for variance!

Main finding #1: Stressful environments result in an increase in transcriptional variance in almost all genes (!) - except for key developmental pathways that remain highly robust 🤯 What is maintaining this selective buffering? We don't know! Ideas?

In this work, led by wonderful PhD student @jphippstan.bsky.social, we collected thousands of Drosophila 🪰 transcriptomes and genomes before and after exposure to environmental perturbation and quantified how stress reshaped transcriptional variability and its genetic architecture. We find...

Have you ever wondered 🤔... Does phenotypic variance respond to environmental perturbation? Does it have a genetic basis? Are mean and variance regulating loci exposed to different selection pressures? These and more questions are explored in our new preprint 🔥

www.biorxiv.org/content/10.6...

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses - Nature Communications Transferring genetic materials between distantly related yeasts, presents technical challenges but can yield industrially interesting phenotypes. Here the authors establish a method to transfer indivi...

Happy to share a recent publication to which I contributed as a corr. author:
www.nature.com/articles/s41...
This work is in collaboration with Dr. Yao Yu at Fudan University, where the team managed to transfer S. cerevisiae chromosmes into K. marxianus, a species diverged from Sc ~114 mya. (1/4)

We are extending the deadline to Feb 27, since we still have a few slots. 👉 A semi-informal event to interact with your peers, learn about cutting-edge research, and hear from two leaders in the field (Sophie Armitage & Dieter Ebert).
And it's free! 🎉
PIs, please recommend to your grad students!

Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

Oft Herr Mendel dreams

that genes form living matter.

They do the latter.

doi.org/10.1093/gene...

Mi gente latino!
Ya llegó ya está aquí. La primera reunión de Biomoleculas antiguas en Latinoamerica patrocinada por el @official-smbe.bsky.social . Reserven la fecha y estén al pendiente de las fechas importantes. Mas info en nuestra pagina web smbeperu.github.io/SMBEperu-esp/

Heya science peeps, my first first-author paper is on Biorxiv! We show how transcriptome-wide expression variability in outbred animals responds massively to an environmental stressor and is underpinned by cryptic variability- (not just mean-) controlling alleles. www.biorxiv.org/content/10.6...

Bay Area Popgen. FREE awesome popgen conference. Registration and application for talks now live on our website!

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

Dear UK #Drosophila @FlyBase Cambridge is now able to accept PO orders for support. So please get in touch with
https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

Beyond Mendel: a new genetics agenda
Most traits aren’t “one gene–one trait”. A perspective paper calls for new experimental paradigms to capture polygenic effects in real environmental context - backed by large-scale automated phenotyping and new infrastructure. Read more: tinyurl.com/2s4d3nwe

Amazing news! Huge congrats, Hadeer!

Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

New Perspective!🔥It's fascinating how scientists from different fields but interested in the same question [e.g. genotype-phenoytpe relationship] can have such different perspectives. Here we put in our 2 cents wrt genetic effects being context-dependent, and pheno variation being mostly polygenic