@mfeltes.bsky.social @stevensalzberg.bsky.social mhwilson@bsky.social

Phenotype to genotype: A new and rapid approach using whole-genome sequencing Author summary Forward genetic mutagenesis screening is an unbiased approach for the identification of mutations linked to a phenotype of interest. While this approach can be a powerful tool for uncov...

Yes, it is crazy that all these papers came out at around the same time! McKenna Feltes in my lab together with my JHU colleagues Alexey Zimin and Steven Salzberg developed this amazing platform called WheresWalker to make positional cloning much easier.

journals.plos.org/plosgenetics...

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins. This was quite a journey for Dan and I and it is great to get it out there for other folks to appreciate - awesome job Dan
doi.org/10.7554/eLif...

PeakClimber: A software tool for the accurate quantification of complex HPLC chromatograms High-performance liquid chromatography (HPLC) is a common medium-throughput technique to quantify the components of complex mixtures like those typica…

www.sciencedirect.com/science/arti...

Today Josh Derrick's paper came out -- A deep dive to create a state-of-the-art method of modeling and quantifying o HPLC Chromatograms - it is both computational and contains "wet lab" experiments. doi.org/10.1016/j.jc...

Creb3l3 deficiency promotes intestinal lipid accumulation and alters ApoB-containing lipoprotein kinetics Elevated levels of triglycerides in the bloodstream, a condition known as hypertriglyceridemia, represent a significant risk factor for the development of metabolic disorders and cardiovascular diseas...

Creb3l3 loss = lipid overload in the gut 🥴
We show that Creb3l3 deficiency leads to intestinal lipid accumulation + altered ApoB lipoprotein metabolism.
Big implications for lipid disorders + metabolic disease!
🔗 www.jlr.org/article/S002...
#lipidmetabolism #zebrafish #CREB3L3 #metabolism

So proud of my lab's output in both papers and presentations at international meetings!

"Questioning is the way of learning,"

Encourage your children to ask questions, not to accept existing answers.

Carl Sagan is one of my heroes right up there with Theodor Seuss Geisel (Dr. Seuss). Sagan's comments are so true now - the consummate scientific communicator.

Carl Sagan is one of my heroes right up there with Theodor Seuss Geisel (Dr. Seuss). Sagan's comments are so true now - the consummate scientific communicator.

I will be there and welcome other Baltimoreans to join me

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

I will be there