SLEEP and SLEEP Advances

Comparison of Sleep Regularity Index (SRI) scores calculated by open-source packages and implications for outcomes research: rationale and design of the RIRI statement (Reporting Items for Regularity ... Abstract. The day-to-day regularity of sleep–wake timing refers to time-varying patterns of behavioral cycles, which co-occur with temporally associated en

This study analyzes the comparability of two widely used #SleepRegularityIndex calculators: #GGIR and #sleepreg. academic.oup.com/sleep/articl...

Efficacy and safety of vornorexant in Japanese patients with insomnia: a randomized, placebo-controlled phase 3 pivotal study AbstractStudy Objectives. A placebo-controlled phase 3 study was conducted to evaluate the efficacy and safety of vornorexant, a novel dual orexin receptor

Vornorexant is studied as an insomnia treatment to improve #sleep quality an #sleep latency in a cohort of Japanese patients academic.oup.com/sleep/articl...

Read our #New Issue for October 2025 here: academic.oup.com/sleep/issue?...

Associations among nonrestorative sleep status, sleep apnea syndrome, and major adverse cardiac and cerebrovascular events: health check-up and claims data in Japan Statement of Significance The present retrospective cohort study using health check-up participants via the health insurance claims database showed the rel

#NonRestorativeSleep can lead to negative impacts on cardiovascular health. This study explores the connection between #NRS, #MAAEC and recently diagnosed sleep apnea. academic.oup.com/sleep/articl...

Performance of an automated sleep scoring approach for actigraphy data in children and adolescents Statement of Significance Proprietary sleep/wake scoring algorithms for actigraphy generally have high sensitivity and low specificity. GGIR is an open-sou

A new R package for reporting #sleep parameters, #GGIR, is tested against the gold standard to see how well it can analyze children's sleep data. academic.oup.com/sleep/articl...

Pre-shift work chronotype matters: resilience as a mediator to shift work tolerance Shift work is an essential aspect of modern society’s 24/7 operations and is particularly indispensable in the medical field. Due to circadian misalignment

Resilience and #sleep chronotype can explain why its harder for some to adapt to shift work. doi.org/10.1093/slee...

The relationship between insufficient sleep, exposure to violence, and violent behaviors in adolescents Firearm injuries are the leading cause of death in US adolescents [1]. Marginalized communities experience greater exposure to violence and face an increas

Not enough #sleep can lead to violent behavior in teens and young adults. academic.oup.com/sleep/articl...

The role of sleep in dementia prevention: building the case for causality Targeting modifiable risk factors is a promising approach to the primary prevention of dementia [1]. Growing evidence suggests that disturbed sleep is one

This editorial focuses on the role of #sleep in #dementia prevention. doi.org/10.1093/slee...

Incorporation of complex narratives into dreaming Statement of Significance This study introduces a systematic approach to assessing dream incorporation by linking presleep experiences to dream content usi

There is a link between dreaming and memory consolidation. In this experiment, researchers put this theory to the test by recording dreams after #REM and #NREM sleep. academic.oup.com/sleep/articl...

Circadian Mechanisms Underlying Post-exercise Blood Pressure Responses in Healthy Adults AbstractStudy Objectives. We aimed to determine whether the endogenous circadian system modulates blood pressure (BP) and its hemodynamic mechanisms during

This study works to understand the impact of #circadian rhythms on blood pressure during exercise. doi.org/10.1093/slee...

Little is understood about sleep during anesthesia-induced unconsciousness. In this study, researchers compare this level of unconsciousness to #NREM in sleep. academic.oup.com/sleep/articl...

Norwegian excellence: high-quality research in a healthy population In this issue of Sleep, Kuldas et al. [1] published results from an impressive Norwegian cohort study that followed 880 Norwegian youth over seven waves fr

It seems logical for increased physical activity to have a positive impact on sleep. In this cohort of Norwegian children, this isn't the case. This study discusses the surprising lack of effect.  academic.oup.com/sleep/articl...

Sleep remains important for cognitive, immunological, and behavioral wellbeing. This study elaborates on how sleep is crucial in collaborative settings. academic.oup.com/sleep/articl...

The future of sleep medicine is here: how modern data analytics can help answer age-old questions in sleep medicine Artificial intelligence has experienced exponential growth in a wide range of fields, including sleep medicine. Machine learning allows researchers to proc

Sleep medicine has focused on #PSg data for insights on the phenomenon. However, this article suggests the use of Artificial Intelligence (#AI) to answer the unknowns of sleep. academic.oup.com/sleep/articl...

Unsupervised clustering of extensive physiological features substantiates five-stage sleep staging paradigm Abstract. Traditional sleep staging, guided by the American Academy of Sleep Medicine (AASM) scoring manual, categorizes sleep into five discrete stages ba

The rationale behind the accepted five-stage sleep cycle is unearthed in this reframing experiment using EEG, EOG, and EMG signal data. academic.oup.com/sleep/articl...

Home-based video-polysomnography for sleep-related motor behaviors: development, feasibility, and diagnostic performance at the Bologna Sleep Center AbstractStudy Objectives. For most sleep disorders, in-laboratory video-polysomnography (VPSG) is currently considered the gold diagnostic standard. Howeve

For most sleep disorders in-laboratory video-polysomnography #VPSG is considered the gold diagnostic standard. Yet there is a need for more accessible diagnostic tools. This study explores evaluating sleep-related motor behaviors using home VPSG at a sleep center. academic.oup.com/sleep/articl...

Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation AbstractStudy Objectives. Circadian disruption is a common phenomenon that can cause various physiological and psychological problems, including cognitive

Here C57BL/6 mice were exposed to irregular light–dark cycles for 15 weeks in a rhythmic box. Cognitive behavioral & histopathological assessments evaluated impact on cognitive function & used metabolomics to explore underlying mechanisms of #circadian disruption academic.oup.com/sleep/articl...

Continuous positive airway pressure effects on energy expenditure, intake, hormonal regulation, and body composition: a randomized trial AbstractStudy Objectives. Weight gain after continuous positive airway pressure (CPAP) initiation in obstructive sleep apnea (OSA) is common, but its mecha

This open-label randomized trial evaluated #CPAP effects on energy expenditure, intake, body composition, physical activity, and appetite-regulatory hormones. academic.oup.com/sleep/articl...

Associations between weekend catch-up sleep and health-related quality of life using a generalized additive model and sex and chronotype sub-analysis Statement of Significance Previous studies on weekend catch-up sleep (WCUS) and health-related quality of life (HRQoL) have analyzed WCUS as a categorical

In healthy adults without severe medical conditions from the Korea National Health and Nutrition Examination Survey, authors used a generalized additive model to investigate non-linear associations between #WeekendCatchupSleep and #HelathRelatedQualityofLife academic.oup.com/sleep/articl...

Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study AbstractStudy Objectives. Cerebrovascular events are more frequent in the morning, coinciding with disturbed circadian rhythms and poor sleep quality. Neur

This study explores whether #NeurovascularCoupling (NVC), a marker of neuronal activity and endothelium-dependent cerebrovascular function, shows circadian variation and whether it is associated with sleep quality.
academic.oup.com/sleep/articl...

Leveraging wearable data for genetic sleep research Chan and colleagues [1] leveraged Fitbit-estimated sleep and genomic data from the All of Us Program to investigate if genetic variants—previously genome w

Wearable data holds promise for genetic sleep research. Find more here: academic.oup.com/sleep/articl...

Individual, social, and environmental predictors of insomnia symptom trajectories in a population cohort of Australian adolescents aged 13 to 17 years AbstractStudy Objectives. The aim of this study was to identify heterogeneous insomnia symptom trajectories in a population cohort of adolescents during a

This study explores insomnia symptom trajectories in a cohort of #adolescents (ages 13-17), and explores the influence of individual, social, and environmental predictors on these different trajectories.
academic.oup.com/sleepadvance...

Relaxation of social time pressure reveals tight coupling between daily sleep and eating behavior and extends the interval between last and first meal Abstract. As a day-active species, humans abstain from some or all foods and beverages and rest at night. The modern social clock diverged from the natural

With data from a global survey of 5,747 adults, authors found that relaxation of the social time pressure during COVID19 restrictions led to an average 42 min increase in the habitual fasting duration (FD), extended by lengthening pre-sleep fasting & sleep durations
academic.oup.com/sleep/articl...

New Issue Alert! Head to the link below for the latest from #SLEEP academic.oup.com/sleep/issue?...

Decoding the sleep enigma: a proteomic mediation analysis linking healthy sleep patterns to lung cancer risk Statement of Significance This study reveals how healthy sleep patterns may contribute to lung cancer prevention. By analyzing data from nearly 35 000 indi

The biological link between sleep patterns and lung cancer remains an enigma. This study aims to explore how healthy sleep patterns modulate lung cancer risk through proteomic mediation, and develop a sleep-related biomarker panel. 
academic.oup.com/sleep/articl...

Towards long-term sleep staging via wearable reflective photoplethysmography AbstractStudy objectives. Sleep staging is usually performed by manual scoring of polysomnography (PSG), which is expensive, laborious, and poorly scalable

Sleep staging is usually performed by manual scoring of polysomnography #PSG, which is expensive, laborious, & not scalable. We propose an alternative for ambulatory sleep staging using wearable photoplethysmography #PPG recorded by a smartwatch & automated scoring academic.oup.com/sleep/articl...

Exploring circadian and meal timing impacts on cortisol during simulated night shifts AbstractStudy Objectives. Cortisol regulates various physiological systems and exhibits a circadian rhythm influenced by sleep–wake and light–dark cycles.

The cumulative effects of consecutive night shifts and nighttime eating on cortisol dynamics are not well understood. This sub-study of a larger randomised controlled trial aimed to explore these relationships. academic.oup.com/sleep/articl...

Delayed phase in rest-activity rhythms is associated with inflammation and cognitive performance in people living with HIV AbstractStudy Objectives. People living with HIV (PLWH) are at increased risks for chronic inflammation and cognitive impairment. Circadian disruption has

People living with HIV (#PLWH) are at increased risk for chronic inflammation & cognitive impairment. Circadian disruption in #PLWH is understudied. This study analyzed data from 87 #PLWH in the UK Biobank w/ valid wrist actigraphy recordings & no dementia diagnosis academic.oup.com/sleepadvance...

Resynchronizing the system: adolescent circadian alignment as a public health imperative Dear Editor,

Catch this letter to the editor from a current high school student detailing the public health imperative to better support adolescent sleep and circadian rhythms academic.oup.com/sleep/articl...

Here, authors describe #DistillSleep, a single-channel electroencephalogram (#EEG) framework that delivers accurate, real-time, and interpretable sleep staging on resource-constrained devices. academic.oup.com/sleep/articl...