Maria Duca

Synthetic RNA ligands as activators of type I toxin–antitoxin systems: a novel antimicrobial strategy targeting Helicobacter pylori Targeting RNAs with synthetic small molecules represents a privileged avenue for the discovery of new therapeutic approaches and offers the possibility to identify original targets escaping the classi...

The last article of the team is out in @chemicalscience.rsc.org Check it to see how #RNA could open the way to the discovery of new antibiotics, congratulations to all authors !
pubs.rsc.org/en/content/a...
@icn-cnrs.bsky.social @univcotedazur.bsky.social @cnrscotedazur.bsky.social
#MyFirstChemSci

Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!

Do look up: how science and international cooperation closed the ozone hole Forty years ago this month, scientists reported that human activities had punctured Earth’s protective ozone layer. What happened next offers a masterclass in international science-diplomacy.

Forty years ago this month, scientists reported that human activities had punctured Earth’s protective ozone layer.

What happened next offers a masterclass in international science-diplomacy
https://go.nature.com/43607zu

Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA RNA targeting represents an original and promising approach to the discovery of new therapeutic tools against numerous diseases. The majority of intracellular RNAs are noncoding RNAs that play key reg...

We recently developed a comprehensive set of assays to identify small-molecule binders for MALAT1 lncRNA, look at the results we obtained recently published in ACS Chemical Biology @pubs.acs.org great collaboration with Sanofi #RNA #RNAtargeting #chembio #medchem pubs.acs.org/doi/10.1021/...

Would you like to know more about how streptomycin, an aminoglycoside antibiotic, affects tumor-initiating cells ? Have a look to our recent paper out on @cp-cellchembiol.bsky.social ! @icn-cnrs.bsky.social @univcotedazur.bsky.social @cnrscotedazur.bsky.social #chembio #aminoglycosides

We were granted and happy to welcome Dr David Leboeuf from LIMA Strasbourg and Pr Isabelle Gillaizeau from Orleans for great conferences ! 👍😊🤩 HFIP magic solvent and metal-catalyzed heterocycles synthesis on the program !! 🥰🥰🥰 @icn-cnrs.bsky.social @univcotedazur.bsky.social

I am really honored by this recognition and thankful to @pacascf.bsky.social as well as to my team and the students and postdocs who worked with me over the years! @cnrs.fr @univcotedazur.bsky.social #RNAinFrance #RNA

Est-ce que les DU vont démissionner en masse pour protester contre cette n-ieme diminution de pouvoir de l’échelon local aux dépens des choix politiques nationaux ?

The costs of competition in distributing scarce research funds | PNAS Research funding systems fundamentally influence how science operates. This paper aims to analyze the allocation of competitive research funding fr...

Researchers spend approximately 45% of their time on administrative activities related to #grants rather than actual #research. The current #competition in research #funding has significant drawbacks; evidence-based improvements of the funding system are required: www.pnas.org/doi/10.1073/...

Do not miss the opportunity to apply for the young medicinal chemist and chemical biologist awards in academia and industry from the Société de Chimie Thérapeutique #SCT Apply here www.sct-asso.fr/ymc-academia... or www.sct-asso.fr/ymc-industry... for these 2500€ awards #chembio #medchem

Extremely proud of Jihed Azzouz who recently obtained his PhD in our team working on #RNA targeting using small molecules and receiving the Excellence Award from Université Côte d'Azur, congratulations Jihed! #RNAtargeting #medchem #chembio

What a pleasure to be in Marburg and meet with @olallalab.bsky.social great team! Thank you for everything and thanks to MiNu graduate school!

Design and Evaluation of Azaspirocycles as RNA binders This study describes efficient synthetic routes for the preparation of novel azaspirocycles. The resulting molecules exhibit unique three-dimensional structures with potential applications in drug di...

What better than a new paper as a first post in bluesky: chemistry-europe.onlinelibrary.wiley.com/doi/full/10.... I have been lucky to collaborate with Laurent Micouin and Erica Benedetti on new azaspirocycles as original RNA binders #RNA #RNAtargeting #medchem #chembio