Aurélie Dobric

We are recruiting! Our lab is looking for a new mass cytometry technician to help study colorectal cancer organoid perturbation experiments at scale.

Please feel free to contact me with any questions!

Full job description and application details here: www.ucl.ac.uk/work-at-ucl/...

A lovely way to close this previous (old?) chapter of my life and focus on the new adventures that lie ahead 🚀

Huge thanks to every single co-author, and supportive PhD supervisors - this wouldn’t have been possible without them.

A few years and countless microscope hours later, this paper brings a beautiful close to my time at the #CRO2 and @crcm.bsky.social

This work brings yet more evidence that E-cadherin - a molecule we thought we knew so well - still has surprising pro-tumoral roles, especially through its subcellular localisation in cancer cells.

E‐Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer The appearance of hybrid epithelial–mesenchymal (E/M) cells expressing E-cadherin is favourable for the establishment of pro-invasive function. Although the potential role of E-cadherin in cancer inv...

Thrilled to finally share the last part of my PhD work on adhesive molecules in PDAC - now published.
Interested in E-cad?? ⬇️
onlinelibrary.wiley.com/doi/10.1111/...

Exciting days ahead. 2 news toys arrived in @christophertape.bsky.social’s lab.
More parallelised experiments soon to come 🤩🤩

We are recruiting for a new Research Technician to join the @cruk-cityoflondon.bsky.social Organoid Platform!

Full details at: www.ucl.ac.uk/work-at-ucl/...

NEW EQUIPMENT JUST DROPPED!

Thanks to @southrock.bsky.social, we will upgrade the HiTS drug screening platform of @crcm.bsky.social with several devices.

Today, we installed a ViaFlo (INTEGRA), which will offer flexibility for our drug screening on 3D models, especially patient-derived tumoroids.

Thanks Francoise!

In this review, we explore how single-cell technologies provide cell-type specific insights and how multimodal techniques uncover the coordination between signalling layers to drive cell fate.

High-dimensional signalling analysis of organoids Cellular phenotypes are regulated by dynamic signalling processes that involve proteins, post-translational modifications, epigenetic events, and tran…

Excited to share today, a whole new chapter in my scientific journey.
TAPELab( @christophertape.bsky.social) latest review on ‘High-dimensional signalling analysis of organoids’ is now online.

Full review available here: www.sciencedirect.com/science/arti...

Very proud of Marseille right now ❤️

Doing good science is 90% finding a science buddy to constantly talk to about the project.

If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!

A captivating subject that I’ve been following closely for a while.

Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer - Nature Communications Targeting cancer stem cells (CSCs) has great potential in anti-cancer treatment. Here this group reports the role of antibiotic Nifuroxazide as a potent anti-CSC compound and fabricates it into an ant...

Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells

www.nature.com/articles/s41...

I think the CRC field ‘may’ have too many gene signatures

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...

#ECMatrix guides #CellFate and patterning

www.nature.com/articles/s41...

EMT-related cell-matrix interactions are linked to states of cell unjamming in cancer spheroid invasion Biophysics; Biomechanics; Cancer

Interesting study in the invasion field.

Overview of the retriever algorithm.

A computational tool, retriever, that extracts disease-specific drug response signatures to predict the best combinations for #cancer treatment.
https://buff.ly/42Y3RoA

Calling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.

YouTube video by Société de Biologie Cellulaire de France - SBCF SBCF - After Movie - La SBCF fête ses 40 ans

A must watch 🤩 (in french 🇫🇷) to grasp the wizardry and benefits provided by the @sbcf French Society for Cell Biology www.youtube.com/watch?v=SmLa...

🌟 Today, we celebrate International Day of Women and Girls in Science! 🔬
To all the incredible women and girls breaking barriers, and inspiring the next generation - thank you for your brilliance and perseverance💡
Hear about Clemence's inspiring journey at UCL: bit.ly/4jTWp3x
#WomenInScience

Let’s give it another try 1y later 👋🏻

Oook let’s start again here ! 🔬🧫🥼