Martin King

Redirecting

Here, we critically review the structures of the mitochondrial pyruvate carrier (MPC) in apo and ligand-bound states, highlighting controversies with regard to the orientation in the inner membrane, interpretation of the transport states, and modelling of the inhibitors.
doi.org/10.1016/j.ti...

06.12.2025 12:47 — 👍 9    🔁 5    💬 0    📌 0

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier Nature - CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.

CRISPR-based tools can’t easily access the DNA in mitochondria, but researchers are finding other ways in

go.nature.com/46WbLQL

19.10.2025 11:49 — 👍 75    🔁 19    💬 2    📌 1

SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis!

www.sciencedirect.com/science/arti...

11.10.2025 13:42 — 👍 10    🔁 3    💬 0    📌 0

Characterised members of the human SLC25 mitochondrial family. Members of the mitochondrial carriers are shown in rainbow (blue to red) cartoon and surface representations with their primary substrates shown in sphere representations to scale. Only one paralogue is shown.

Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...

25.07.2025 11:29 — 👍 32    🔁 9    💬 0    📌 0

holy shit lmao

19.07.2025 03:21 — 👍 26573    🔁 5042    💬 493    📌 719

This is amazing, and is a huge step forward. Congratulations to all involved!

26.06.2025 07:34 — 👍 0    🔁 0    💬 1    📌 0

In space, Venus flanks Earth on the left, with a hellfire greenhouse effect. Mars on the right, which long ago had running water. Today, it's bone dry. Something bad happened on each planet.

Seems like the wrong time to limit the Nation’s capacity to conduct climate research.

05.05.2025 19:25 — 👍 20515    🔁 4807    💬 566    📌 229

Ever wondered why eating something sugary gives you such an energy boost? 🍰

25.04.2025 10:14 — 👍 4    🔁 2    💬 1    📌 0

It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....

28.02.2025 16:59 — 👍 18    🔁 12    💬 1    📌 0

Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....

03.03.2025 17:25 — 👍 7    🔁 6    💬 0    📌 0

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.

Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM

18.04.2025 18:16 — 👍 43    🔁 13    💬 2    📌 0