Double Negative in Cells Could Undermine PARP Inhibitors Published: June 10, 2025Updated: June 11, 2025Written by: Beth DoughertyThere are two ways to fix things: the quick way and the careful one. In cancer, cells with BRCA1 mutations tend to choose the quick fix, leaving them vulnerable to medicines like PARP inhibitors.   PARP inhibitors cause DNA to break. When broken strands and sketchy repairs ... Read more

A new study led by Dipanjan Chowdhury, PhD, co-director of our Center for BRCA and Related Genes, uncovers why some cancers resist PARP inhibitors. The findings could help guide more personalized treatment strategies.

Learn more about the study: bit.ly/4ko5CAq

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA Assistant/Associate Professor, Chemical Biology job

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...

Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @xingulab.bsky.social

xingulab.dana-farber.org

New research in @pnas.org led by @danafarber.bsky.social’s Yubao Wang, PhD, in the lab of Tom Roberts, PhD, explored an engineered, degradable form of a small viral protein and made new insights into a key cell growth pathway often hijacked by cancer cells.

Read more: bit.ly/4ezpMpE

Following State and City Approvals, New Cancer Hospital and Clinical Collaboration Enters Next Phase | Dana-Farber Cancer Institute With the recent completion of a multi-agency, state and city regulatory process, the clinical collaboration among Dana-Farber Cancer Institute (Dana-Farber), Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical Faculty Physicians at BIDMC (HMFP) is moving forward. The collaboration will support a new Dana-Farber cancer hospital, and the joint clinical teams are developing comprehensive plans to transform cancer care around the world and push the boundaries of research and innovation.

In collaboration with Beth Israel Deaconess Medical Center, our new dedicated cancer hospital, projected to open in 2031, will strengthen Boston’s position as a global leader in oncology — and expand access to the most advanced care for patients across the region.

bit.ly/402eQej

quick reminder to join us tonight at @harvardmed.bsky.social for a great talk by Colby Ford @colby.tuple.xyz

So happy and proud to see our story online!! Thank you, the midnolin team!

Congratulations Xin!!

Thank you @shalinhnaik.bsky.social for participating in our NIC interview series! We really appreciate it 🤩

A cup of blue ice cream in front of a Friendly's tent at the Jimmy Fund Scooper Bowl.

A crowd of people gather at the Jimmy Fund Scooper Bowl.

Scooper Bowl® has officially kicked off at Boston City Hall Plaza! Join us now through Thursday, 12-8pm each day, for unlimited ice cream all to benefit @danafarber.bsky.social. 🍦🩷

🎟️: jimmyfund.gives/BSDay

#boston #bostonevents #bostonfoodies

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7) Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...

NEW PREPRINT ALERT: Buhrlage lab in collaboration with @irinabezsonova.bsky.social has developed a new class of USP7 activators!

www.biorxiv.org/content/10.1...

Brian Wolpin, MD, MPH, of Dana-Farber Cancer Institute

Congrats to @danafarber.bsky.social’s Brian Wolpin, MD, MPH, a 2025 Giants of Cancer Care by @onclive.bsky.social. Dr. Wolpin is recognized for his remarkable achievements in #gastrointestinal and #pancreatic cancer research and clinical practice.

➡️ bit.ly/3RTq7ZS

188 PhD/graduate fellowships from private foundations, federal agencies and international organizations.

Database can be downloaded here: research.jhu.edu/rdt/funding-...

Eric Smith, MD, PhD, of Dana-Farber receives Outstanding New Investigator Award

Congratulations to Eric Smith, MD, PhD, @danafarber.bsky.social on receiving the Outstanding New Investigator Award from @asgct.bsky.social. Smith will present on advancing CAR T cell therapy for cancer immunotherapy. #ASGCT2025

#NationalNursesWeek

Happy #NationalNursesWeek! In this video, @danafarber.bsky.social’s Senior VP for Patient Care Services & CNO Anne Gross is joined by a patient’s mother and other members of the NPCS team in discussing what relationship-based care means to them. bit.ly/44U7WLc

Zero-shot design of drug-binding proteins via neural selection-expansion Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1...
🧵🧪

YouTube video by Boston Protein Design and Modeling Club Design of small molecule binding proteins using deep learning

in case you missed the superb seminar that Ben Fry gave back in January, you can now check out the recording youtu.be/IgFgAYQrke4
and the preprint www.biorxiv.org/content/10.1...

GelGenie has finally been published in Nature Communications (DOI: doi.org/10.1038/s414...)!

GelGenie is a free, open-source app for the one-click extraction of band data from gel images using AI, all bundled within a cross-platform GUI that can be integrated in your workflow immediately. 🧬

Recently, the Mass Public Health Council voted unanimously to approve @danafarber.bsky.social’s plans to build a 300-bed cancer hospital in the Longwood Medical Area. Read more about how a stand-alone cancer hospital will increase equitable access to care: bit.ly/4jeqCcu

Targeted degradation of CDK9 potently disrupts the MYC-regulated network Toure et al. investigate a known challenge in CDK9 inhibition—the compensatory increase in MYC levels. They demonstrate that a selective CDK9 degrader with rapid kinetics circumvents this effect, prov...

From the team of Angela Koehler and colleagues at MIT, an excellent analysis of how CDK9 degradation differs from CDK9 inhibition with respect to Myc regulation. Congratulations!
www.cell.com/cell-chemica...

A method for the detection and enrichment of endogenous cereblon substrates C-Terminal cyclic imides are posttranslational modifications on proteins that are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN). Despite the observation of these modificati...

New preprint out co-led by Hannah Lloyd and Christina Woo at Harvard along with colleagues at the Broad and CeTPD Dundee gives insight on how to detect and discover native substrates of CRBN!
www.biorxiv.org/content/10.1...

Induced proximity at the cell surface - Nature Biotechnology Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford!
www.nature.com/articles/s41...

Congratulations to @danafarbernews.bsky.social’s Matthew Meyerson, MD, PhD, FAACR, @drchoueiri.bsky.social, and Alice T. Shaw, MD, PhD, recipients of @theaacr.bsky.social 2025 Scientific Achievement Awards. bit.ly/4j7m8om

Public Statement on Supporting Science for the Benefit of All Citizens TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...

Worth reading and sharing

docs.google.com/document/d/1...

Congratulations to @danafarber.bsky.social’s Bradley Bernstein, MD, PhD, A. Thomas Look, MD, and William R. Sellers, MD, who have been elected as Fellows of @theaacr.bsky.social Academy Class of 2025. #AACRFellows bit.ly/41RE1Bs

Research in Cell Genomics led by @danafarber.bsky.social's Bradley Bernstein, MD, PhD, presents an AI transformer model developed in collaboration with Google Advanced Sciences which can predict gene expression. https://bit.ly/42zNVsj

There's no better way to start the new year than by hearing the exciting science of organoids! 🤩 Join us for the first 2025 New Investigator Committee webinar on January 8th.