Antibody framework is overlooked but important in antigen binding and propagating conformational changes to perform effector functions.

Another preprint: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. www.biorxiv.org/content/10.1...

17.03.2025 09:44 — 👍 1    🔁 0    💬 0    📌 0

#ImmunoSky Happy to share our new work led by recently graduated Dongjun Guo - exploring how #antibody heavy and light chains form specific pairs. Fine-tuning an antibody language model, we asked how pairing propensities change in #bcell maturation and in diseases. 📄 www.biorxiv.org/content/10.1...

12.03.2025 10:31 — 👍 1    🔁 0    💬 0    📌 0