Claire McCarthy

#MarchMovieChallenge
#Moviesky
#Filmsky

Day 13: Working dog in a movie

Balto

If you see this, post a vampire that isn't Dracula.

If you see this, post a robot .....🤖

What's a line delivery you'll never forget?

#WomensHistoryMonth Day 12 - Conservationist and writer Rachel Carson helped spark the #environmental movement with her book 'Silent' Spring', about the dangers of pesticides.

Where in the World...did she write 'Silent Spring'?
Click to find out: www.whereintheworldgame.com?id=214&type=q

#Science

Aging, stress inside cells, and promoting cancer metastasis
www.nature.com/articles/s41...
AT4 is the effector of the integrated stress response, enriched in patients of advanced age with cancer and correlated with poor survival (Figure)

#MarchMovieChallenge
#Moviesky
#Filmsky

Day 12: Coca Cola in a Movie

The Breakfast Club

🎉 The overall winner of this year’s #DanceYourPhD contest is Sofia Papa. She and five other dancers re-create the piezoelectric effect, the ability of some crystalline materials to generate electricity when subjected to stress.

Learn more: https://scim.ag/4rtrGgq

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlying stroma, creating a fibronectin-rich precancerous niche that supports tumour survival.

Nature research paper: Precancerous niche remodelling dictates nascent tumour persistence

go.nature.com/4l8AgzC

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma Rade et al. present a longitudinal single-cell atlas of BCMA CAR-T therapy in multiple myeloma, revealing that cilta-cel drives potent CD4⁺ cytotoxic responses and superior outcomes. Their findings identify plasmacytoid dendritic cells as unexpected BCMA-expressing targets and suggest therapeutic potential in blastic plasmacytoid dendritic cell neoplasm.

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth Mateus-Tique et al. demonstrate that targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity, leading to tumor clearance and improved survival in models of metastatic cancers.

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

CCL3 is produced by aged neutrophils across cancers and promotes tumor growth Bolli et al. develop a classifier that rescues neutrophils typically lost in scRNA-seq data, enabling unified pan-cancer analyses. This approach identifies CCL3hi aged tumor-associated neutrophils conserved across human and mouse cancers. Mechanistic perturbations show that neutrophil-derived CCL3 drives their CCR1-dependent survival in hypoxic niches, thereby promoting tumor progression.

CCL3 is produced by aged neutrophils across cancers and promotes tumor growth

Explore the human body in stunning, 3D detail with a new online tool The free Human Organ Atlas gives users an up-close-and-personal look at 56 human organs.

“With the Human Organ Atlas (HOA), users can travel through the brain, heart, lungs, kidneys, and liver and better understand our anatomy and the diseases that threaten it. The platform is detailed in a paper published today in the journal Science Advances”
🧪 #Scicomm
www.popsci.com/health/human...

a cartoon drawing of the capitol building with a blue sky in the background .. ALT: a cartoon drawing of the capitol building with a blue sky in the background ..

I’m Just a Bill

“Anything is possible when you have the right people there to support you.”
- Misty Copeland
#WednesdayWisdom

#MarchMovieChallenge
#Moviesky
#Filmsky

Day 11: Parents of a LGBTQ character in a movie

Aristotle and Dante Discover the Secrets of the Universe
youtu.be/ukLWHUBAPJI

Choose your top 25 favorite cartoons. One per day for 25 days, in no particular order.
No explanations, no reviews.

Day 25: Schoolhouse Rock!

Forget SkinTok: the real science of skincare and why it matters for your health Skip the complicated regimens and expensive products seen on social media. The science of skin is deep but the recommendations are simple.

What does science really tell us about skincare? Skin is sometimes described as the largest organ in the human body. Turns out advice on how to look after it is rarely based on real science. Nor does it emphasize the link with overall health

🧪
www.nature.com/articles/d41...

Chemistry labs make tons of plastic waste. Can we recycle it? Chemists and innovative recyclers are trying to turn gloves, pipette tips, and other laboratory plastic waste into something useful

Chemists and innovative recyclers are trying to turn gloves, pipette tips, and other laboratory plastic waste into something useful.

#chemsky 🧪

How ancient pottery preserves plant-eating proof Organic residues on pots from northern and eastern Europe show plants were an important part of the local diet several thousand years ago

Analysis of 85 pieces of Mesolithic pottery from hunter-gatherer-fisher communities in northeastern Europe shows the value of combining analytical techniques to improve the understanding of ancient diets and cooking methods.

#chemsky 🧪

Large drugmakers are developing fewer antibiotics, analysis finds The number of potential antimicrobial treatments being developed by the world’s largest drugmakers nosedived by 35% over the past five years, according to a new analysis.

More reporting from @statnews.com on the struggling pipeline for new antibiotics to treat drug-resistant infections

www.statnews.com/pharmalot/20...

Challenges at the earliest, most fraught stages of drug development are likely a contributing factor.

#MarchMovieChallenge
#Moviesky
#Filmsky

Day 10: Favorite pop song used in a movie

Dirty Dancing
(I’ve Had) The Time of My Life

Choose your top 25 favorite cartoons. One per day for 25 days, in no particular order.
No explanations, no reviews.

Day 24: Ed, Edd n Eddy

Of the many impressive acrobatic qualities of cats, perhaps their most spectacular is their ability to right themselves midair so they always seem to land on their feet. The trick lies in a hyperflexible region of their backbone known as the thoracic spine, a new study finds. https://scim.ag/4rlHodw

Why ‘quantum proteins’ could be the next big thing in biology Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells.

“In the past, it might have seemed like, ‘ah, that’s likely never going to work’,” says physicist Ania Jayich. “That’s not true any more.”

go.nature.com/3NdJMF1

B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity Chen et al. find that a specific B cell subset is associated with immunotherapy resistance in bladder cancer. IGLL5+ B cells interact with HEVs through IGLL5-LTβR signaling, leading to the impairment of TLSs formation in humanized mouse models. This interaction presents a promising therapeutic target for overcoming immunotherapy resistance in bladder cancer.

B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity

How fast does a protein fold? Real-time technique captures the moment Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

How fast does a protein fold? Real-time technique captures the moment @nature.com
www.nature.com/articles/d41...

Pipeline of new drugs to fight superbugs is ‘worryingly thin’, experts warn UK’s GSK is leading the way in research but AstraZeneca is not involved in the area, report finds * Business live – latest updates The pipeline of new drugs to fight superbugs remains “worryingly thin” and has shrunk by 35% in the last five years, experts have warned, predicting the annual number of deaths linked to drug-resistant infections globally will double to 8 million by 2050. The number of projects from large pharma companies has shrunk by 35% over the past five years, from 92 to 60 medicines in development, according to a report from the Access to Medicine Foundation (AMF), a Netherlands-based non-profit group, and the Wellcome Trust. Continue reading...

Pipeline of new drugs to fight superbugs is ‘worryingly thin’, experts warn

This biomaterial becomes stronger when wet Nickel-linked chitosan forms a biodegradable plastic replacement

Most biobased materials soften when they’re wet. A team led by Javier G. Fernández at the Institute for Bioengineering of Catalonia has now shown that the opposite can happen: add a dash of nickel to chitosan, and the material grows stronger in water. #chemsky 🧪

The Warning - Kerosene (Official Video) YouTube video by TheWarningVEVO

Listening to Kerosene by The Warning: youtu.be/xGRH6MvX2Oo #MusicMonday #Musicsky