Ingo Hartung

RSC Medicinal Chemistry promotional graphic for the Induced-Proximity Pharmacology collection, with QR code.

📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James!

Explore the articles that make up this fantastic collection, here👇
pubs.rsc.org/en/journals/...

#chemsky 🧪

Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.

Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!

This paper sounds interesting. Oh wait… @proxidrugs.bsky.social

It was fun meeting you in many sessions (including posters of mutual interest 🤐). Connecting with past, current & potentially future colleagues makes 10 hours of travel worth the effort.

Guess who is sitting in front of me…

I guess this means I made it through immigration… #AACR25

🚀 An inspiring milestone worth sharing! 🎥
Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!

Mario Vargas Llosa: An Appreciation The Peruvian author Mario Vargas Llosa was the world’s savviest and most accomplished political novelist.

Una copa bien en alto por uno de mis autores favoritos. Gracias por las historias, las palabras, y la valentía. Buen viaje, Mario. 🥂📚
Farewell to the Last Writer of the Latin American Boom www.nytimes.com/2025/04/13/b...

Life could be worse… unfortunately, a pretty busy working week ahead.

First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.

Several big scientific conference are held each March-April-May in the US. Every scientist from Europe I talk to says something like „not sure that I should really go there“. It‘s an opportunity to meet colleagues and I give a talk, otherwise I would for sure not travel to the US in this situation.

Best place for conferences in the US. No other conference center comes close. Take a walk at the marina for me!

The analogy to the UK is a very good one. Don‘t forget that Labour lost with Jeremy Corbyn to an already dysfunctional Tories government under Boris Johnson in a landslide. It took additional years of Tories chaos and a candidate like Starmer who dialed down left rethoric to win a majority.

She spoke of a genocide committed against the Palestinians.

Some of AOC‘s comments about Israel/Gaza are enough that I - as a middle of the road voter (in Europe) - would never support here. With the average US voter being more conservative than Europeans that leaves her with zero electoral chances outside the Bronx.

I expected more from him in the recent campaign. But my perspective watching from Europe may have been incomplete. From over here he looked like the funny uncle everybody likes at family parties but you would never give your wallet to. And there was no content in the Harris campaign anyway.

Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.

Fangt doch an. Oder was ist der Auftrag von Journalismus? Agenturmeldungen nachdrucken ist es nicht.

Besonders die Einleitung des Artikels ist wichtig. Ich frage mich die ganze Zeit: warum sollte Putin warten, bis Europa sich besser verteidigen kann? ME ist das einzige, was ihn noch aufhält, der ukrainische Widerstand.

This is The main problem of US politics IMO: The only Democrats able to build a credible opposition movement are so far to the left that they would never ever win an election against a JD Vance/Rubio ticket. Where are the candidates for middle of the road voters? And where are these voters hiding?

A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…

More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...

A small molecule USP7 activator from the Buhrlage Group! Important information in the SI not to be missed: significant activity differences between enantiomers & an inactive control compound. A very strong data package further enabling studies of USP7 biology.

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away!

Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery.

📅 April 29, 2025 | ⏰ 5:00-5:45 PM
Learn more👇

#CancerResearch

Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader Pfizer and Arvinas’ estrogen receptor (ER) degrader has

Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...

This one is more challenging… still to early to give an assessment.

What a book! Very well deserved Booker Prize. Must-read recommendation. #ChemistsWhoRead

Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…

Einigen wir uns drauf, dass dieses Wahlergebnis einfach großer Murks ist.