Juan C. Sanchez-Arcila (he/ele/él)

it's wild that R, the ubiquitous statistical computing language, was co-created by a Māori prof (Ross Ihaka) — and yet the vast majority of scientists who use R don't know

this is like inventing the toaster. possibly the largest impact of a single member of an indigenous community on modern science

photo of paulina borsook

1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it).

But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that

It is a shame... @duolingo became an app probably manages through AI. They never answer one email, they have a horrible costumer service. And still they want to ask and ask to subscribe to their services. I won't renew my plan for sure.

Al Hilal x Fluminense vai ser basicamente o poder do dinheiro infinito vs. o poder da amizade

Vim só para dar um Oiiii nessa mensagem :) 🇭🇺

esse daí apertou 17 com força

No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations Nature Communications - Repeated vaccination is needed to maintain high levels of SARS-CoV-2 immunity in vulnerable populations, but there is concern that it could lead to immune exhaustion. Here,...

No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations

Does repeated vaccination cause "immune exhaustion"? No, the immune system can handle multiple hits from similar or different stimuli. It evolved to do so!

www.nature.com/artic...
1/5

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below:
www.science.org/doi/10.1126/...
@cytokinesociety.bsky.social

Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

@elespectador.com miren, aprendan a hacer periodismo así.

One of the most powerful revelations for your personal and political growth is this: if you live long enough, you’ll become disabled.

No one is immune to illness, injury, or aging.

If you’re not committed to disability justice for altruistic reasons, commit for selfish ones. And guard your health.

Meio cafona essa mensagem do “Deus é brasileiro” neste momento de dor dos argentinos.

I don’t remember when was the last time I saw an excellent TV show such as The Pitt

Vaccination in pregnancy to protect the newborn - Nature Reviews Immunology In this Review, Male and Jones provide an overview of the current vaccines that are offered during pregnancy and to newborns, explaining the rationale behind the different vaccination programmes and t...

👶🏼 Many #vaccines are not effective in newborns. So how do we protect them from infectious disease?

🤰🏽 By vaccination in #pregnancy!

Here we review…

💉 Established campaigns vs whooping cough, flu, COVID

💡 New approaches to RSV, GBS

🌈 Future challenges, opportunities

#ReproSky #ImmunoSky #IDSky

Please see the new tour de force from @danaaghabi.bsky.social PhD! We think that we have finally found the major Toxoplasma iron/zinc importer. Thanks to ID21 at the @esrf.fr, and help from UGs and the lab.
This is what I wanted to find when I started my lab, and thanks to Dana we have it!

Aren’t you applying for it, Francesca?

This is great! Congratulations!

FYI, you uploaded the readcube link that does not permit to see the paper cover because a paywall, at least in my phone.

Just in case, could you please upload the Nature link directly? Thanks!

An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...

In the silence of chromatin, Toxoplasma whispers change.
TgSNF2h sculpts the genome - MORC in the backseat.
Some genes wake. Others sleep.
A dance of nucleosomes shaping space for life parasite stages to unfold.

Now in Nature Microbiology:
rdcu.be/ehkWp

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

Mi mamá nunca supo que existían y me tocó aprender a cortar con la derecha

A natural experiment on the effect of herpes zoster vaccination on dementia Nature - Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a...

A natural experiment on the effect of herpes zoster vaccination on dementia

Neurotropic herpes viruses may be implicated in the development of dementia. Can vaccines reduce this risk? Yes, they can!

www.nature.com/artic...
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Tissue-like multicellular development triggered by mechanical compression in archaea The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

Naaaasaaaaaaaaooooooooo

I lost my friend strike with my brother because I was between flights on a loooog trip. Please help me to recover it! 🫣

The Worm That No Computer Scientist Can Crack One of the simplest, most over-studied organisms in the world is the C. elegans nematode. For 13 years, a project called OpenWorm has tried—and utterly failed—to simulate it.

"biology tends to quickly humble the computer people"

www.wired.com/story/openwo...