We just covered this paper in our joint journal club with @maxrenner.bsky.social group. Very impressive! Congrats all authors.
www.nature.com/articles/s41...
New OpenFold3 preview out! (OF3p2)
It closes the gap to AlphaFold3 for most modalities.
Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
Is that the venue for next year? Sounds tempting to go then too!
This is Nathan Cavanaugh, another DOGE staffer explaining how he flagged grants at NEH for "DEI" which would be reviewed for termination. 404 Media has reviewed hours of this footage and we'll have more soon.
Part of a lawsuit by @acls1919.bsky.social, @modernlanguage.bsky.social + @historians.org
I'll be at GfV (Society for Virology) in Heidelberg next week. Haven't had time to check in with "everyone" who is going, so feel free to reach out if you'll be there and want to meet up. :)
De novo generation of the furin cleavage site (FCS) in influenza viruses
In SARS-CoV2, the existence of an FCS was a key argument of lab leakers that it must have been constructed in the lab.
Fantastic work
Automatic screening of cryo-EM grids using EPU is fast and efficient, but reviewing the generated data & picking the best areas for data collection can be slow and cumbersome. We made a little tool that makes this process more streamlined and enjoyable: github.com/mvorlander/E... 1/4
The countdown begins! Less than one week until the 35th Annual Meeting of the Society for Virology is taking place in Heidelberg.
Check the website for all current updates (incl. detailed program): virology-meeting.de
#GfV #GfV2024 #virology #virologymeeting #VirusResearch
I used this page for fun a few times in the past, it is indeed nice. Thanks for creating it!
Remembering Philip E. Bourne
Phil was a key figure in launching the RCSB PDB and served as Associate Director from 1998-2013
The green light looks cool :)
The juvenile sea squirt swims the ocean currents, actively searching for the perfect place to live. Once it finds a nice, solid rock, it sticks itself down and gets to work reabsorbing bits it no longer needs - including its own brain.
This post is about human civilisation.
The number of cancer deaths worldwide has more than doubled since the 1980s. Does that mean we're losing the fight against cancer? Not necessarily, because it depends on how you measure it. On this chart, you can see three ways to look at the same data. 🧵
Hot off the press!
I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published!
Link to the paper: www.pnas.org/doi/10.1073/...
Nature is full of remarkable protein nanomachines, and now we can watch one more in action.
When it works, having a cappucino and a Brezel in the bistro at 300 km/h is not bad. When it works....
Hi Fabio, the facility in Umeå does. You can find info including facility contact here (I am a user but I don't work at the facility):
www.umu.se/en/research/...
Culex homini lupus!
"talk to". I cringe every time I find a typo in one of my posts but what can I do...
Visited @pirbrightinst.bsky.social some days ago. What an incredible density of smart and creative virologists! Thanks especially to Helena Maier who arranged my visit, and to everyone I had a chance to talk. Their no-photo-policy makes this post a bit dry, but the place is really outstanding!
Build a paper model of the HIV capsid using this template from PDB-101 #ASBMB2026 #ASBMB26
pdb101.rcsb.org/lear...
Researchers found that treatment of intact HIV capsids with lenacapavir causes capsids to rupture, with ruptures occurring first in areas of the capsid with the highest level of curvature. #ASBMB2026 #ASBMB26
Watch in 3D at PDB-101: pdb101.rcsb.org/motm...
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
I wonder... 🤔🤔🧪 #chemsky
a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT
b) how such high school science level of disgrace pass peer review in @nature.com?
Note this was Fig.4.a NOT in SI
www.nature.com/articles/s41...
Then you shortcircuit Deutsche Bahn?
Train booking in Germany!
A scientist is never certain.
Check out this beautiful study, spearheaded by Kenny @denkenny.bsky.social, on mitochondrial remodeling. Some of the prettiest organelle segmentations I have seen 😍😍😍
www.science.org/doi/10.1126/...
CDC issued a Global Polio Level 2 Travel Health Notice advising enhanced precautions
Tragic. We had polio almost eradicated, but disruption to vaccination campaigns due to COVID, global instability, defunding & vaccine hesitancy have led us here
#VaccinesWork
🧪
wwwnc.cdc.gov/travel/notic...
A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate.
Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...
