MRC National Mouse Genetics Network

Our Best Models Working Group can offer advice on the use of a range of model systems.

The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans.

nmgn.mrc.ukri.org/working-grou...

Our Best Models Working Group can offer advice on the use of a range of model systems.

The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development.

nmgn.mrc.ukri.org/working-grou...

Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting!
🧠🧠🧠🧠

Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!

@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social

Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies

Meet the Experts | National Mouse Genetics Network We connect researchers with specialists in diverse model systems to support innovation and refinement.

Our Best Models Working Group can offer advice on the use of a range of model systems.

The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.

Replacement of Animals in Medical Research | National Mouse Genetics Network Development of new methodologies Animals are used in medical research for investigating the causes and mechanisms of human disease, identifying potential drug targets and testing therapeutic approache...

We plan to facilitate replacement training at the @mrcharwell.bsky.social Advance training centre and our Best Models Working Group provides a forum for researchers to learn about alternative models and connect with experts in other systems
nmgn.mrc.ukri.org/about/replac...

We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.

Our Best Models Working Group can offer advice on the use of a range of model systems.

Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.

Our Best Models Working Group can offer advice on the use of a range of model systems.

Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology.

#MeetTheExpert

Meet the Experts | National Mouse Genetics Network We connect researchers with specialists in diverse model systems to support innovation and refinement.

If you want advice on selecting the most appropriate model for your research, contact the NMGN Best Models Working Group to be connected with researchers with expertise in diverse biological models and computational tools:

nmgn.mrc.ukri.org/working-grou...

#MeetTheExpert #3Rs

Nice place for a bit of work and hopefully some fun!

Last session in full swing! #OrganoidsAreUs2025

Our first session of today's #OrganoidsAreUs2025 is dedicated to organoid models in cancer research.
We go with
✨ Vincenzo Corbo
✨ Ben Dwyer
✨ Maximilian Reichert
✨ Chiara Braconi

Another packed session for a critical and fast-developing field!

Second session on #StemCells #regeneration and #cancer. We start with
🧪 Phil Jones from the @sangerinstitute.bsky.social
🧪 Followed by Suet Yu Leung from Hong Kong Uni and
🧪 Eleanor Earp from @edinburghuni.bsky.social ,
✨ First keynote lecture by Helmuth Gehart from @ethz.ch
#OrganoidsAreUs2025

A day dedicated to #StemCells #regeneration and #cancer. 1st session sponsored by TECAN with Nick Barker from A*STAR, Amian Barai from @univ-amu.fr and our first Tony Burgess Orator, Vivian Li from @crick.ac.uk, providing a fascinating insight into this fast-developing area #OrganoidsAreUs2025

Opening session sponsored by @stemcell.com and OLS with a welcome from Director Owen Sansom @cruk-si.bsky.social and Elizabeth Vincan @unimelb.bsky.social . Our plenary speaker Prof Hans Clevers from @utrechtuniversity.bsky.social talks about human epithelial organoids. #OrganoidsAreUs2025

We are ready to go at the CRUK Scotland Institute, @cruk-si.bsky.social, for this exciting meeting, bringing together a huge wealth of new technologies and scientific advances. First session this afternoon. Watch this space! #OrganoidsAreUs2025

On 14th November, we are once again holding our Network Science Day in York, which is an exciting opportunity for Network members and non-members to engage and develop new collaborations!

The meeting is free to attend. Find out more and register by emailing us at Genetics_Network@har.mrc.ac.uk.

UK facilities workshop on genome engineering technologies

If you lead a facility or research group whose primary focus is on genetic engineering, our upcoming workshop held on behalf of the @mrcmousenetwork.bsky.social may be for you.

Find out more and apply ⬇️
www.crick.ac.uk/whats-on/uk-...

Understanding the Protein Tagging Problem: A New Study from the NMGN Degron Tagging Cluster | National Mouse Genetics Network Celebrating Research Specialists: Driving Innovation in Mouse Genetics Research specialists are often the unsung heroes in biomedical research groups, providing continuity in long-term research progra...

Nice write up on the @mrcmousenetwork.bsky.social
website, highlighting the awesome work of first author Gillian Taylor, is available here: nmgn.mrc.ukri.org/news/underst...

Wellcome Discovery Award for Claus Nerlov of the Heam Cluster | National Mouse Genetics Network Claus Nerlov, Professor of Stem Cell Biology and member of our Haem Cluster, has been awarded funding from Wellcome to map the gene regulatory networks in blood cell production and […]

Claus Nerlov, from the @imm.ox.ac.uk and Haem Cluster member, was awarded a @wellcometrust.bsky.social Discovery Award to map the regulatory networks in blood cell production. This will provide invaluable insight for the development of better therapies for patients
nmgn.mrc.ukri.org/news/wellcom...

A workshop for behavioural scientists on the use of DeepLabCut | National Mouse Genetics Network As part of the effort to disseminate knowledge and skills across the Network and the community, we asked some of our GenerationResearch colleagues at the University of York to organise […]

A workshop about data science and DeepLabCut organised with our colleagues of the University of York and Generation Research. Check out our story about it! nmgn.mrc.ukri.org/news/a-works...

@drpipdunne.bsky.social @cruk-si.bsky.social @uofglasgow.bsky.social @coffeltlab.bsky.social @johanvandevoorde.bsky.social

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!

www.embopress.org/doi/full/10....

Organoids Are Us 2025 Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk

Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.

📆23 - 26 September 2025

📍Glasgow, Scotland

Early bird registration extended to 18th July. Register below! 👇

www.crukscotlandinstitute.ac.uk/events/organ...

Organoids Are Us 2025 Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk

Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.

📆23 - 26 September 2025

📍Glasgow, Scotland

Early bird registration extended to 18th July. Register below! 👇

www.crukscotlandinstitute.ac.uk/events/organ...

Organoid News | Science News Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Interested in staying current with the latest applications and discoveries using
#organoids? Subscribe to Organoid News by STEMCELL Science News to stay on top
of the latest publications, reviews, industry news, and more.

www.stemcellsciencenews.com/organoid-new...

Organoids Are Us 2025 Further information about this event including our invited speakers and conference programme are available in the tabs below. If you have any questions, please contact organoids-are-us@crukscotlandinstitute.ac.uk

Join us for Organoids Are Us 2025, a symposium featuring organoids, stem cells, cancer, inflammatory disorders and infectious disease.

📆23 - 26 September 2025

📍Glasgow, Scotland

Early bird registration extended to 18th July. Register below! 👇

A great example of the Network’s fundamental contributions to our understanding of the biological consequences of molecular manipulation and the benefits of cross cluster #collaborations. Lastly, but not in order of importance, another Network #ECR shining here! Well done Gillian Taylor!