Prof Paul E Squires

No work in sight for the next 5 days 🥳🥳🥳. Salcombe birthday celebrations for the legend that is @paulsquires.bsky.social #Salcombe #SalcombeHarbourHotel ##AnnualLeave #Academic #Lifeofanacadenic #Academia #England #Devon

This #ASNCJASN study analyzed the effects of empagliflozin, a diabetes medication, on kidney function in young people with type 2 diabetes (T2D), suggesting that empagliflozin may help prevent early diabetic kidney disease in youth with T2D. Read more: kidney.pub/CJASN0889

Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | Amer... We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule ...

Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...

Power relations and role boundaries between community first responders and ambulance clinicians in England: a qualitative study - power relations, hierarchy and role boundaries, characterised by subordination of CFRs and collaborative relationships between ambulance staff and CFRs
rdcu.be/eR6fK

164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences

Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!

Wedding Vibes 👰🤵‍♂💒💍 with @paulsquires.bsky.social ..it was a hot one ☀️☀️☀️ #ArdingtonHouse #Oxfordshire #womeninSTEM #annualleave #summertime #UK #Cotswolds #wedding

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this resea

Delighted to have contributed to this editorial
diabetesjournals.org/diabetes/art...

Fantastic article to celebrate the contribution of our very own @chillslincoln79.bsky.social to some amazing work on #worldkidneyday, see:
news.lincoln.ac.uk/2025/03/13/l...

I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦

Contact info on my website.

Fantastic opportunity for fellowship in an excellent T1D research training environment working in regenerative medicine and stem cells in the Breakthrough T1D Centre of Excellence at UBC. If you missed the NOI deadline, no worries, you can still apply! Reach out if you have any questions.

Effect of sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial Sotagliflozin reduced MACE, with independent reductions in myocardial infarction and stroke, among patients with type 2 diabetes, chronic kidney disease, and additional cardiovascular risk. The ischae...

Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial 👩‍🔬🥼🧪👨‍🔬 #cardiosky #SGLT2i #SGLT1/2 #cardiovascular #womeninstem #NephSky 👇👇👇

www.thelancet.com/journals/lan...

A sunday night worth celebrating with @paulsquires.bsky.social after a busy, busy week 🥂🍾. Hopeful that good news will follow 👩‍🔬👨‍🔬🧪 #justbecause #cardiosky #NephSky #womeninSTEM #academic #weekendvibes #champagne ##KidneyResearch #CardioRenal #Cardiovascular

Birthday boy cotswolds celebrations 🥳🥳 @DoubleRedDuke with @paulsquires.bsky.social 🥰🥰 #birthday #cotswolds #England #annualleave #womeninSTEM

FDA Approves Ozempic for Kidney Disease | Docwire News Based on FLOW trial results, the FDA has approved Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes.

📣 Novo Nordisk announces that the FDA has granted approval to its blockbuster drug Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes. 👩‍🔬🥼🧪👨‍🔬

#Semaglutide #diabetes #type2diabetes #nephropathy #GLP-1 👇👇

docwirenews.com/post/fda-app...

Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial - PubMed Semaglutide reduces albuminuria and the risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease (CKD). We conducted a randomized placebo-controlled double-blind ...

📣 Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-clinical trial @naturemedicine.bsky.social 👩‍🔬🥼🧪👨‍🔬 #Semaglutide #KidneyDisease #Obesity #kidney #NephroSky #CardioSky #NephSky 👇👇👇
pubmed.ncbi.nlm.nih.gov/39455729/

#Nephrologist #nephSky #kidneydonor #transplant #kidneydisease #bbcnews #donorappeal

Meon Vale mother of three who needs kidney makes donor appeal Amber Simmonds, 29, has lived with hereditary polycystic kidney disease (PKD) since she was 13.

BBC News - Meon Vale mother of three who needs kidney makes donor appeal - BBC News
www.bbc.co.uk/news/article...

FDA approves Novo Nordisk's Ozempic to treat chronic kidney disease in those with diabetes, expanding its use Expanded Ozempic approval in the U.S. could transform how doctors treat patients with chronic kidney disease, which involves a gradual loss of kidney function.

BREAKING NEWS: The FDA has approved Ozempic for patients with chronic kidney disease. This means the popular injection can be used to reduce the risk of kidney disease worsening, kidney failure and death from cardiovascular disease in patients with chronic kidney disease and diabetes.

Congratulations @cardiacshah.bsky.social & co-author @jo-ward08.bsky.social from team #CardioRenal on publication of this all important review - incorporating clinical guidelines with latest evidence & experience in the management of T2DM in patients with ASCVD 🥳🥳🥳🥳. #diabetes #CardioSky #NephSky

Beautiful
#Salcombe, it never disappoints. The perfect place to switch off and unwind with @paulsquires.bsky.social 🥰🥰 #Lifeofanacademic #AcademicSky ##CardioSky #WomeninSTEM #England #Devon #SalcombeHarbour #Coastal #Coastline #NephroSky

Frontiers | Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations

📣 Congratulations to my PhD student @cardiacshah.bsky.social on his review 'Diagnosis & management of type 2 diabetes mellitus in patients with ischaemic heart disease & acute coronary syndromes - a review of evidence & recommendations' 👇👇 #CardioSky #diabetes

www.frontiersin.org/journals/end...

Checking out of all things work for the next 9 days with @paulsquires.bsky.social. Heading to Salcombe for sea air, coastal walks and yummy food and wine 🫒🍲🥖🥂🍷. Stay tuned for glorious pictures of the English Coast 🌊🌊 #FancyPants are on 😉 #WomeninSTEM #Weekend #Salcombe #England #Coastal

Bracing but beautiful day in Salcombe with @paulsquires.bsky.social ❤️ #Salcombe #Devon #AnnualLeave #womeninSTEM #CardioSky #NephroSky

<em>Diabetic Medicine</em> | Diabetes UK Journal | Wiley Online Library Click on the title to browse this issue

Our special issue for DiabeticMedicine entitled 'From Bench to Bedside: An integrated and multi-disciplinary approach to tackling diabetic kidney disease' is available online now. 👇👇 #KidneyDisease #Diabetes #NephSky #KidneyResearch #Diabetes #CardioSky

onlinelibrary.wiley.com/toc/14645491...

A glorious walk today, albeit a slightly freezing day in Kenilworth. ❄️❄️❄️ #academicsky #cardiosky #nephsky #Warwickshire #saturday #countrylife #womeninSTEM

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3 days back at work. Let's just say this wine is well deserved 🤣🤣. Thank heavens I have @paulsquires.bsky.social by my side to keep me sane 😬 #WomeninStem #cardiosky #Nephsky #academiclife #drama #womeninnephro

Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice - Nature Communications Here the authors show that lowering IGF-1R levels in endothelial cells improves insulin sensitivity, boosts energy use, and supports beneficial changes in adipose tissue, offering insights into potent...

Metabolite-mediated inter-tissue signalling. Led by Jane Luk & Mark Kearney @unileedsnews.bsky.social in @naturecomms.bsky.social we identify malonic acid as an IGF1R-regulated endothelial-to-adipocyte metabokine mediating adipose metabolism. Great start to 2025.
www.nature.com/articles/s41...

Interested in #GLP-1 , #Semaglutide #cardiovascular and #kidneydisease ? 👩‍🔬🥼🧪🧪Just out @thelancet.bsky.social 👇👇.

Thanks for sharing @paulsquires.bsky.social 👍

#CardioSky #NephSky #diabetes #kidneys #womeninSTEM