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Jonathan Eisen

@phylogenomics.bsky.social

Professor at UC Davis Work: phylogenomics & evolvability of host-microbiome systems; #openscience; Other: #birds; baseball; T1D Lab phylogenomics.me Pics jonathaneisen.smugmug.com Links linktr.ee/jonathaneisen TED go.ted.com/6WPm

32,237 Followers  |  8,207 Following  |  2,389 Posts  |  Joined: 06.08.2023
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Posts by Jonathan Eisen (@phylogenomics.bsky.social)

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Epistasis and co-adaptation in bacterial genome evolution Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...

I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional β€˜gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts!

rdcu.be/e6pHY

02.03.2026 15:48 β€” πŸ‘ 72    πŸ” 38    πŸ’¬ 4    πŸ“Œ 1
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Over 40? Your rotator cuff probably looks a little rough MRI scans of over 600 Finnish adults found that nearly all had frayed, torn or otherwise abnormal rotator cuffs β€” yet most had no symptoms.

In this testing & data obsessed time, studies like this good reminder often useless & harmful!

Over 40? Your rotator cuff probably looks a little rough www.sciencenews.org/article/shou...

Study: "RC abnormalities nearly universal after age 40 years & routine imaging should NOT guide diagnosis..."

03.03.2026 17:16 β€” πŸ‘ 18    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
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Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a β€œsexist attitude”

This is a nice contrast to all the awful behavior confirmed through the Epstein files. Proud of @jenlucpiquant.bsky.social & @seanmcarroll.bsky.social for picking up on the sexism & charlatanism right away.

03.03.2026 15:29 β€” πŸ‘ 310    πŸ” 97    πŸ’¬ 7    πŸ“Œ 15
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after absolutely eviscerating Kristi Noem and calling for her resignation, Tillis is applauded. He thens threatens to hold up nominees if she doesn't stop stonewalling him. My God.

03.03.2026 17:55 β€” πŸ‘ 14080    πŸ” 3656    πŸ’¬ 675    πŸ“Œ 536

OOOOOOHHHHH - We should definitely talk

03.03.2026 17:15 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
User Executive Committee | Joint Genome Institute The UEC represents the JGI user community and is responsible for providing input and advice on JGI policies and practices.

And, also relevant, I am here in part as a representative of the @jgi.doe.gov user community - as I was just elected to be a member of the "User Executive Committee" jgi.doe.gov/who-we-are/c...

03.03.2026 17:14 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Integrating Experimentation with Data | Joint Genome Institute Join the Joint Genome Institute and the Environmental Molecular Sciences Laboratory for β€œEmpowering Automated Laboratories: Integrating Experimentation with Data.”

I note - I am in Seattle for the @jgi.doe.gov User Meeting - see more details here jgi.doe.gov/work-with-us... - this year the meeting is a joint meeting with EMSL

03.03.2026 17:07 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
Webinar poster titled "Mining New Frontiers," scheduled for February 27, 2026, at 9am PT. Includes a QR code for registration. Features logos of JGI, Molecular Foundry, and Berkeley Lab, and images of minerals and a growing plant.

Webinar poster titled "Mining New Frontiers," scheduled for February 27, 2026, at 9am PT. Includes a QR code for registration. Features logos of JGI, Molecular Foundry, and Berkeley Lab, and images of minerals and a growing plant.

Join us Feb. 27 for more on our joint Critical Minerals & Materials call with @molecularfoundry.lbl.gov β€” for projects that integrate genomics w/nanoscale science to develop bio-based technologies.
πŸ–₯️🧬

Details: https://jgi.doe.gov/work-with-us/proposals/jgi-tmf-critical-minerals-and-materials-call

19.02.2026 16:45 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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JGI Announces FY26 Large Scale Portfolio for Our Community Science Program | Joint Genome Institute A series of headshots below the text: Congratulations to our Large Scale Call recipients"

"These projects highlight the creativity of our user community and their commitment to tackling fundamental scientific challenges..." β€”User Programs Deputy Tanja Woyke. πŸ–₯️🧬

More: https://jgi.doe.gov/user-science/science-stories/jgi-announces-fy26-large-scale-portfolio-our-community-science-program

02.03.2026 21:28 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Nice view from near the @jgi.doe.gov user meeting in Seattle (yesterday)

03.03.2026 16:34 β€” πŸ‘ 36    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

$300 Million in jet planes lost to a fuckup.

That’s 83 five year NIH R01 grants burned in minutes due to error, aka poor execution of this unnecessary war which serves only to make the world more dangerous.

02.03.2026 15:28 β€” πŸ‘ 150    πŸ” 63    πŸ’¬ 0    πŸ“Œ 1
This image features a banner for the American Academy of Microbiology, announcing a new fellow for the Class of 2026. It includes a headshot of a smiling individual and logos for the American Society for Microbiology and the American Academy of Microbiology.

This image features a banner for the American Academy of Microbiology, announcing a new fellow for the Class of 2026. It includes a headshot of a smiling individual and logos for the American Society for Microbiology and the American Academy of Microbiology.

Congrats to Emiley @emileyeloe-fadrosh.bsky.social on being selected as a fellow for the American Academy of Microbiology's Class of 2026. Full story: go.lbl.gov/Eloe-Fadrosh_AAM

More on our Metagenome Program: https://jgi.doe.gov/science-programs/metagenome-program

@asm.org @microbiomedata.org

23.02.2026 21:24 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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2025 Progress Report | Joint Genome Institute Learn more about the JGI's 2025 accomplishments, including research and data output.

Our FY25 Progress Report is now live! We broke our own record by sequencing more than 1Pb of data in a yearβ€”on top of serving 2,627 users w/active proposals, plus 17K researchers making use of our data.
πŸ–₯️ 🧬 🌱 πŸ„ 🦠 πŸ§ͺ

Full report: https://jgi.doe.gov/user-science/science-stories/2025-progress-report

24.02.2026 17:54 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

This is an incredible resource:

The MicrobeAtlas Database www.cell.com/cell/fulltex...

02.03.2026 15:03 β€” πŸ‘ 34    πŸ” 14    πŸ’¬ 0    πŸ“Œ 0
Close up of a male Anna's hummingbird hovering. Facing to the left. Wings in front of body. Red throat showing.

Close up of a male Anna's hummingbird hovering. Facing to the left. Wings in front of body. Red throat showing.

Anna's hummingbird. Davis, CA.

Photo taken with Nikon D500, Nikkor 500 mm f/ 5.6.

#birds #hummingbirds

02.03.2026 00:12 β€” πŸ‘ 101    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1

Correct. Or SNAP payments

02.03.2026 02:57 β€” πŸ‘ 12    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Sad to hear of the passing of David Botstein, one of the greats in that 1st gen of folks to be trained in molecular biology. He generously talked with me, a lowly grad student, about Barbara McClintock... 30 years ago!
@drgregorymorgan.bsky.social @alistairsponsel.bsky.social

02.03.2026 02:05 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Close up of a male Anna's hummingbird hovering. Facing to the left. Wings in front of body. Red throat showing.

Close up of a male Anna's hummingbird hovering. Facing to the left. Wings in front of body. Red throat showing.

Anna's hummingbird. Davis, CA.

Photo taken with Nikon D500, Nikkor 500 mm f/ 5.6.

#birds #hummingbirds

02.03.2026 00:12 β€” πŸ‘ 101    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1
Einstein

A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine

careers-einstein.icims.com/jobs/17847/a...

01.03.2026 23:38 β€” πŸ‘ 23    πŸ” 29    πŸ’¬ 1    πŸ“Œ 0

Thinking about David Botstein, who passed away a few days ago.

In searching for stories about my work w/ him I found something I had never seen - a lecture where he discusses a paper on MutS from when I was in grad school (which I discussed with him extensively).

youtu.be/giEySXUewsk?...

01.03.2026 18:41 β€” πŸ‘ 21    πŸ” 2    πŸ’¬ 2    πŸ“Œ 1

Thinking about David Botstein, who passed away a few days ago.

In searching for stories about my work w/ him I found something I had never seen - a lecture where he discusses a paper on MutS from when I was in grad school (which I discussed with him extensively).

youtu.be/giEySXUewsk?...

01.03.2026 18:41 β€” πŸ‘ 21    πŸ” 2    πŸ’¬ 2    πŸ“Œ 1
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David Botstein | 1942 - 2026 | Online-Tribute.com David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…

Crap

www.online-tribute.com/DavidBotstein

David Botstein passed away. I worked with him at Stanford for a few years in designing and teaching a course on "The Heart". My heart is heavy right now. He was a wonderful mentor.

28.02.2026 22:35 β€” πŸ‘ 106    πŸ” 17    πŸ’¬ 5    πŸ“Œ 6
Angled-down image of a frog perched on a brown leaf and facing left. The frog's principal ground color is black, with yellowish-white stripes running from the nose through the eye and down the back to the legs. A second stripe runs along the lower jaw, terminating at the front legs. The legs are a light brown and there is a triangular flashmark of bright yellow at the top of the thigh. The frog also has some dark brown blobs attached to the lower back - four tadpoles, hanging on until the male frog can transport them to a suitable source of water.

Angled-down image of a frog perched on a brown leaf and facing left. The frog's principal ground color is black, with yellowish-white stripes running from the nose through the eye and down the back to the legs. A second stripe runs along the lower jaw, terminating at the front legs. The legs are a light brown and there is a triangular flashmark of bright yellow at the top of the thigh. The frog also has some dark brown blobs attached to the lower back - four tadpoles, hanging on until the male frog can transport them to a suitable source of water.

Know what doesn't suck right now, or ever? Nature. This Pale-striped Poison Frog (Ameerega hahneli) was hopping across an open area at our NE Peru field station, on his way to find a suitable wet place to deposit his tadpoles (such as the axils of a bromeliad). #herps #frogs #NaturePhotography 🌿

01.03.2026 02:20 β€” πŸ‘ 406    πŸ” 49    πŸ’¬ 7    πŸ“Œ 1

I find the news very frightening right now, but one thing that helps me is noticing the birds all around me

Do you want a reason to spend 10 minutes a day noticing your local birds? Then join me for this spring’s #TenMinMerlin, using the (free) app Merlin to notice birds. No experience needed!

1/5

01.03.2026 03:11 β€” πŸ‘ 307    πŸ” 70    πŸ’¬ 11    πŸ“Œ 15

RIP David Botstein
#MicroSky

01.03.2026 02:33 β€” πŸ‘ 37    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Ah, no. What a terrible loss. He was a wonderful scientist who touched so many of our lives.

01.03.2026 00:10 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Very sad to see this. I worked with him in Calico, David was a giant.

28.02.2026 23:08 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Cheer David, We will miss you. Thank you for everything.

28.02.2026 23:43 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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David Botstein | 1942 - 2026 | Online-Tribute.com David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…

Crap

www.online-tribute.com/DavidBotstein

David Botstein passed away. I worked with him at Stanford for a few years in designing and teaching a course on "The Heart". My heart is heavy right now. He was a wonderful mentor.

28.02.2026 22:35 β€” πŸ‘ 106    πŸ” 17    πŸ’¬ 5    πŸ“Œ 6
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It's a good day for some hummingbirds -- gif of a hovering Anna's hummingbird in my yard in #DavisCA #birds

28.02.2026 22:16 β€” πŸ‘ 57    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1