Cell Systems

Should biology put complexity first? The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

Should biology put complexity first? By @philipcball.bsky.social www.cell.com/cell-systems/fulltext/S2405-4712(25)00030-4

What is the main bottleneck in deriving biological understanding from spatial transcriptomic profiling? Image-based approaches to single-cell transcriptomics offer the exciting ability to directly image gene expression at the transcriptome scale within intact tissue slices, defining, discovering, and ma...

We asked J. Moffitt, M. Li, Q., K. Kanemaru, S. Teichmann, D. Dar, S. Itzkovitz, R. Vento-Tormo, @ltkagohara.bsky.social @itaiyanai.bsky.social @fertiglab.bsky.social @fabiantheis.bsky.social about bottlenecks facing Spatial Transcriptomics www.cell.com/cell-systems/abstract/S2405-4712(25)00033-X

Inferring cell trajectories of spatial transcriptomics via optimal transport analysis Shen et al. introduce SpaTrack, which integrates cell transcriptomics and spatial position using optimal transport to reconstruct cell differentiation trajectories. SpaTrack is applied to disentangle ...

Shen et al. introduce SpaTrack to reconstruct cell differentiation trajectories from spatial transcriptomics data at single cell resolution within a spatial context by using optimal transport www.cell.com/cell-systems/abstract/S2405-4712(25)00027-4

Our February issue is online. On the cover: Regenerative trajectories of axolotl telencephalon regeneration inferred by SpaTrack using spatial transcriptomic data. www.cell.com/issue/S2405-4712(24)X0003-4#closeFullCover

In 2024, we reached out to 50 scientists who are doing innovative research around the world. 🧵

You can read our interviews with them in our #50ScientistsThatInspire collection: www.cell.com/topic/cell-d...