Andrew Chow

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

Everyone should watch and share. Thank you David. youtu.be/8YhJM6zxYDw

Hundreds of Thousands Will Die The writer, surgeon, and former U.S.A.I.D. senior official Atul Gawande on the Trump Administration’s decimation of foreign aid and the consequences around the world.

www.newyorker.com/podcast/the-...

NIH slashes overhead payments for research, sparking outrage Move to cut indirect cost rate to 15% could cost universities billions of dollars

1/ Why this is🚨?

My colleagues, collaborators, and I are funded by #NIH to bring the most promising medicines to people with life-threatening illness

How does this work?

www.science.org/content/arti... #oncsky #lcsm

Jia Luo 1,2 , Justin A. Bishop3, Steven G. DuBois4, Glenn J. Hanna1,2, Lynette M. Sholl 5, Edward B. Stelow6,Lester D. R. Thompson7, Geoffrey I. Shapiro 1,2 & Christopher A. French 5 Abstract In the past two decades, treatment for non-small-cell lung cancers(NSCLCs) and head and neck squamous cell carcinoma (HNSCC) hasadvanced considerably, owing largely to the characterization of distinctoncological subtypes, the development of targeted therapies for eachsubtype and the advent of immunotherapy. Data emerging over thepast two decades suggest that NUT carcinoma, a highly aggressivemalignancy driven by a NUT fusion oncoprotein and arising in the lungs,head and neck, and rarely in other sites, is a squamous cell carcinoma(SCC) based on transcriptional, histopathological, cell-of-origin andmolecular characteristics. NUT carcinoma has an estimated incidenceof 1,400 cases per year in the United States, surpassing that of somerare NSCLC and HNSCC subtypes. However, NUT carcinoma is currentlynot recognized as an SCC of the lungs or head and neck. The orphanclassification of NUT carcinoma as a distinct entity leads to a lack ofawareness of this malignancy among oncologists and surgeons, despiteearly diagnosis being crucial for this cancer type with a median survivalof only ~6.5 months. Consequently, NUT carcinoma is underdiagnosedand often misdiagnosed, resulting in limited research and progress indeveloping effective treatments in one of the most aggressive formsof lung and head and neck cancer. With a growing number of targetedagents that can potentially be used to treat NUT carcinoma, improvedrecognition through reclassification and inclusion of NUT carcinomaas a squamous NSCLC or an HNSCC when arising in these locations willaccelerate the development of effective therapies for this disease. Thus,in the Perspective, we propose such a reclassification of NUT carcinomaas an SCC and discuss the supporting evidence.

🌟 In Nature Reviews Clinical Oncology,

we examine the *overwhelming* evidence for classifying NUT carcinoma as a subtype of squamous lung cancer and squamous head and neck cancer

🫁 🗣️ rdcu.be/d8uni @natrevclinoncol.bsky.social #medsky #oncsky #meded #lcsm #lungcancer

🧵 Highlights:

Trump Administration Offers 2 Million Federal Workers Payouts to Resign (Gift Article)

If you offer an across-the-board buyout to 2 million people, the best have outside options and will take it; the worst have none and will stay.

Either (1) Elon Musk is an idiot, and he doesn't understand adverse selection or worse yet (2) he isn't, he does, and he wants the best gone.

Gift link:

I ran @USAID health programs for the last 3 years. Trump’s 90 day Stop Work Order on foreign assistance does serious damage to the world and the US. Examples:🧵

Vice President JD Vance, Rep. Mike Turner, Rep. Jason Crow Face the Nation with Margaret Brennan · Episode

open.spotify.com/episode/6FAc...

Killing Cancer Patients (Once the Payments Clear)

A terrifying new report by John Carreyrou illustrates why we have those pesky regulations and those irritating clinical trials:

I Was Kamala Harris’ Videographer. I Wish I Could Show You What I’ve Seen. She completely changed me.

slate.com/news-and-pol...

Elon’s extreme hatred of his former friend Sam Harris seems to have begun after Elon made a bet with Sam that Covid would never top 35,000 cases in the US, and was proven spectacularly wrong.
samharris.substack.com/p/the-troubl...

Why Debate Over Vaccines And Autism Will Continue How do you win a debate, when the arguments you’re presented with keep changing? Such is the problem with the dispute over whether vaccines – and specifically the shot for measles, mumps, and rubella ...

My article from a decade ago on vaccine hesitancy, the anti-vax movement, and the risk of a measles resurgence in the U.S. As relevant today as it was when this article was first published by Forbes.

h/t @karaswisher.bsky.social

Quote of the Day: @anneapplebaum.bsky.social
from her latest Atlantic article

A lot of people seem to struggle with this but 50% is actually much better than 0%

President #JimmyCarter died today at age 100, having lived w/ #melanoma that had spread to his brain & liver for >9y. I grew up in GA admiring him, so as an oncologist, I’d like to honor his life by teaching a bit. #melsm #MedSky #OncSky #MedEd

First, the ⚠️ signs (ABCDE 👇) & some examples:

/1

Why do RFK Jr. apologists think eliminating NIH study sections is a good idea? Dr. Vinay Prasad thinks nominee for NIH director Dr. Jay Bhattacharya should do a "randomized trial" of study sections vs. a "modified lottery" to make research grant funding decisions. WTF?

www.respectfulinsolence.com/2024/12/23/w...

‘A Terrible Irony’: How the Media Lost Trust And a template for rebuilding it

Post election, I've been trying to report more on the decline of trust in institutions. Obviously the media's crisis is part of this. Last week, I came across a paper from @juliaangwin.com that looks at how creators build trust w/ their audiences & I called her up. Lots of good lessons here, imo

A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate (Gift Article) A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?

www.nytimes.com/2024/12/22/h...

bsky.app/profile/altm...

Harvard Professors Leaving for Private Sector Research | Harvard Magazine Three distinguished scientists on leaving academia to advance biomedical research

www.harvardmagazine.com/2025/01/harv...

Weakness Is a Provocation ABC News, billionaires, media orgs, and CEOs are surrendering to Trump because they think he’s a lame duck. They’re making a terrible mistake.

We have established a playing field in which the forces of MAGA can slander, libel, and defame with near impunity...while simultaneously using libel law to attack legitimate critics in an attempt to chill everyone else’s speech.”

From @jvl.bsky.social

open.substack.com/pub/thebulwa...

#395 - Intellectual Authority and Its Discontents Making Sense with Sam Harris - Subscriber Content · Episode

open.spotify.com/episode/5iNC...

Opinion | No, Jay Bhattacharya wasn't 'censored' by the government Dr. Jay Bhattacharya made his name by claiming he was censored during the Covid pandemic. But it never happened.

"Dr. Jay Bhattacharya made his name by claiming he was censored during the Covid pandemic. But it never happened." Great piece by @mmasnick.bsky.social. Also worth noting...

www.msnbc.com/msnbc/amp/rcna183120

Why Debate Over Vaccines And Autism Will Continue How do you win a debate, when the arguments you’re presented with keep changing? Such is the problem with the dispute over whether vaccines – and specifically the shot for measles, mumps, and rubella ...

My mentions are full of notes that @scottgottliebmd.bsky.social's comments about RFK + vaccines should be ignored because he is on the board of Pfizer.

FWIW, here's SG saying similar things in 2015, before he joined that BOD. www.forbes.com/sites/scottg...

(I oversaw Scott's writing at Forbes.)

Vaccines are being attacked left and right BECAUSE they work so well that people have conveniently forgotten about polio and poxes.

Here is a contemporary example in oncology. Vaccines prevent cancer and reduce cancer deaths - do you know how hard THAT is??

Spread the words - vaccine save lives!

THREAD: Research we should be thankful for.

The chances that we and everyone we know and love would be here today, alive, healthy and thriving without the advances of science and technology are basically zero.

Today we look through the research and scientists to whom we owe everything.


1/19

Dr. Scott Gottlieb on RFK: He will cost lives in this country if he follows through on intentions Dr. Scott Gottlieb, former FDA commissioner and CNBC contributor, joins 'Squawk Box' to discuss the incoming administration's picks for health cabinet positions, where Gottlieb's worries are, and much...

From my segment today on @cnbc.com. We face a grim and avoidable resurgence of once vanquished childhood infectious diseases if we follow down the current path being taken in Washington.

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

There has been a great migration of scientists from Twitter to Bluesky, writes @kakape.bsky.social. Obviously you're already here, but it's still worth a read. 🔭
www.science.org/content/arti...

Bluesky Is Growing Up. Maybe Too Fast. The fledgling social media site has been flooded by people seeking alternatives to Facebook, X and Threads. It hasn’t all been easy.

Over the past week, the social media site Bluesky's growth has exploded, more than doubling to 15 million-plus users, as people seek alternatives to X, Facebook and Threads.

Silicon Valley Sunglasses

Silicon Valley Sunglasses is a classic from @dereklowe.bsky.social (if planning name a fallacy after your favorite thought leader please bear in mind that Andy Grove died within a year of the post)
www.science.org/content/blog...